Determining Factors of Arterial Stiffness in Subjects with Metabolic Syndrome

Cozma, Angela; Sitar-Tăut, Adela; Orășan, Olga Hilda; Leucuţa, Daniel; Alexescu, Teodora; Stan, Adina; Negrean, Vasile; Sampelean, Dorel; Pop, Dana; Zdrenghea, Dumitru; Vulturar, Romana; Fodor, Adriana

doi:10.1089/met.2018.0057

“…Data from the literature on the prevalence of metabolic syndrome are different and often controversial. These differences, including the present study, can be explained by the lower number of patients enrolled in our analysis, but also by the definition used in the diagnosis of metabolic syndrome, criteria in which obesity is no longer considered mandatory for the diagnosis of metabolic syndrome and the value of pathological glycemia is e" 100mg% [43,46,47]. It is known that the main pathogenetic link of the metabolic syndrome is insulin resistance, insulin hyperproduction leading to depletion of â-pancreatic cells and thus to hyperglycemia and type 2 diabetes even before this pathology is diagnosed when atherogenic dyslipidemia [35][36][37].…”

Section: The Study Of Insulin Resistance In Overweight and Obese Patimentioning

confidence: 70%

“…The prevalence of metabolic syndrome increases as the degree of obesity increases, the presence being twice as high, statistically significant (p <0.001) in subjects with grade I obesity than in normoponderal ones and statistically As is well known, metabolic diseases are the major health problem of this century, including in our country [43]. The prevalence of obesity has increased threefold in the last 10 years in Romania, with a predisposition to metabolic diseases with extremely adverse consequences for the individual as well as for the family and society [5].…”

Section: The Study Of Insulin Resistance In Overweight and Obese Patimentioning

confidence: 73%

Metabolic Profile and the Risk of Early Atherosclerosis in Patients with Obesity and Overweight

Alexescu¹,

Bordea²,

Cozma³

et al. 2019

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Obesity and Overweight have the highest rate of incidence and prevalence in the past 3 decades, as global pathologies. The purpose of this study was to evaluate cardiovascular, classic and modern risk factors in overweight and obese patients by studying lipid metabolism (total cholesterol, HDL-cholesterol, non-HDL-cholesterol, LDL-cholesterol, serum triglycerides), glucose metabolism, insulin resistance and insulin sensitivity, the prevalence of hypertension (HBP) and the prevalence of metabolic syndrome (MS). This analytical study was performed on 111 subjects divided as follows: Group I consisting of 27 normal weight subjects - NW; Group II consisting of 84 overweight and obese subjects - OW + O: 36 overweight patients - OW; 33 patients with grade I obesity - O-I; 13 patients with grade II obesity - O-II; 2 patients with grade III obesity - O-III. The overweight and obese, although unknown with heart disease, have significant metabolic changes, such as atherogenic dyslipidemia, dysglycemia, high insulin resistance and low insulin sensitivity, metabolic syndrome, these being the first steps towards endothelial dysfunction and early atherosclerosis.

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“…As is well known, metabolic diseases are the major health problem of this century, including in our country [43]. The prevalence of obesity has increased threefold in the last 10 years in Romania, with a predisposition to metabolic diseases with extremely adverse consequences for the individual as well as for the family and society [5].…”

Section: The Prevalence Of Hbp In Overweight and Obese Patientsmentioning

confidence: 99%

Metabolic Profile and the Risk of Early Atherosclerosis in Patients with Obesity and Overweight

2019

Rev.Chim.

0

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Obesity and Overweight have the highest rate of incidence and prevalence in the past 3 decades, as global pathologies. The purpose of this study was to evaluate cardiovascular, classic and modern risk factors in overweight and obese patients by studying lipid metabolism (total cholesterol, HDL-cholesterol, non-HDL-cholesterol, LDL-cholesterol, serum triglycerides), glucose metabolism, insulin resistance and insulin sensitivity, the prevalence of hypertension (HBP) and the prevalence of metabolic syndrome (MS). This analytical study was performed on 111 subjects divided as follows: Group I consisting of 27 normal weight subjects - NW; Group II consisting of 84 overweight and obese subjects - OW + O: 36 overweight patients - OW; 33 patients with grade I obesity - O-I; 13 patients with grade II obesity - O-II; 2 patients with grade III obesity - O-III. The overweight and obese, although unknown with heart disease, have significant metabolic changes, such as atherogenic dyslipidemia, dysglycemia, high insulin resistance and low insulin sensitivity, metabolic syndrome, these being the first steps towards endothelial dysfunction and early atherosclerosis. Keywords: obesity, metabolism changes, insulinoresistance, overweight

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“…The importance of oxidative stress in osteoarthritis disease is fully recognized at present [7]. In cardiovascular pathology, the increase of oxidative stress promotes atherosclerosis with related complications (hypertension, dyslipidaemia, peripheral artery disease, metabolic syndrome, diabetes and obesity) [8,9]. Starting from this premise, in recent years, we have resorted to the evaluation of the fraction of exhaled nitric oxide (FeNO) as an objective marker of eosinophilic bronchial inflammation.…”

Section: Introductionmentioning

confidence: 99%

Modification of exhaled air nitric oxide in patients with asthma – cortisone monotherapy or dual inhalation therapy?

Ruta

¹

,

Motoc

²

,

Todea

³

et al. 2020

Ann Agric Environ Med.

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Determining Factors of Arterial Stiffness in Subjects with Metabolic Syndrome

Abstract: Given the known predictive value of pulse wave velocity for cardiovascular events, identifying the factors responsible for the increase in arterial stiffness is extremely important.

Cited by 21 publications

References 46 publications

Metabolic Profile and the Risk of Early Atherosclerosis in Patients with Obesity and Overweight

Metabolic Profile and the Risk of Early Atherosclerosis in Patients with Obesity and Overweight

Metabolic Profile and the Risk of Early Atherosclerosis in Patients with Obesity and Overweight

Modification of exhaled air nitric oxide in patients with asthma – cortisone monotherapy or dual inhalation therapy?

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