Determining changes in bone metabolism after bariatric surgery in postmenopausal women

Luhrs, Andrew; Dávalos, Gerardo; Lerebours, Reginald; Yoo, Je Hyun; Park, Chan; Tabone, Lawrence E.; Omotosho, Philip; Torquati, Alfonso; Portenier, Dana; Guerrón, Alfredo D.

doi:10.1007/s00464-019-06922-8

Cited by 14 publications

(7 citation statements)

References 28 publications

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“…Lowered estrogen exposure reduces the risk of developing ER-positive breast cancer [225]. However, a concern after bariatric surgery is decreased bone density, which could also be attributed to reduced estrogen levels [229,230]. Therefore, bariatric surgery-induced weight loss and reductions in adiposity would be beneficial in reducing overall estrogen concentrations, but this reduction comes with potential side effects that must be monitored.…”

Section: Bariatric Surgery and Metabolic Signalingmentioning

confidence: 99%

The role of obesity and bariatric surgery-induced weight loss in breast cancer

Bohm

Sipe

Pye

et al. 2022

Cancer Metastasis Rev

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Obesity is a complex metabolic condition considered a worldwide public health crisis, and a deeper mechanistic understanding of obesity-associated diseases is urgently needed. Obesity comorbidities include many associated cancers and are estimated to account for 20% of female cancer deaths in the USA. Breast cancer, in particular, is associated with obesity and is the focus of this review. The exact causal links between obesity and breast cancer remain unclear. Still, interactions have emerged between body mass index, tumor molecular subtype, genetic background, and environmental factors that strongly suggest obesity influences the risk and progression of certain breast cancers. Supportive preclinical research uses various diet-induced obesity models to demonstrate that weight loss, via dietary interventions or changes in energy expenditure, reduces the onset or progression of breast cancers. Ongoing and future studies are now aimed at elucidating the underpinning mechanisms behind weight-loss-driven observations to improve therapy and outcomes in patients with breast cancer and reduce risk. This review aims to summarize the rapidly emerging literature on obesity and weight loss strategies with a focused discussion of bariatric surgery in both clinical and preclinical studies detailing the complex interactions between metabolism, immune response, and immunotherapy in the setting of obesity and breast cancer.

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Section: Bariatric Surgery and Metabolic Signalingmentioning

confidence: 99%

The role of obesity and bariatric surgery-induced weight loss in breast cancer

Bohm

Sipe

Pye

et al. 2022

Cancer Metastasis Rev

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“…Another recent study addressing postmenopausal women found no significant differences between SG and RYGB in total and regional BMD after surgery. However, despite this fact, there was a clear decrease in the BMD of ribs and spine after surgery in both groups, which suggests that DEXA could have an important role postoperatively among high-risk women [53].…”

Section: Reviewmentioning

confidence: 81%

The Impact of Bariatric Surgery on Bone Health: State of the Art and New Recognized Links

et al. 2022

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Bariatric surgery (BS) is the most effective therapy for severe obesity, which improves several comorbidities (such as diabetes, hypertension, dyslipidemia, among others) and results in marked weight loss. Despite these consensual beneficial effects, sleeve gastrectomy and Roux-en-Y gastric bypass (the two main bariatric techniques) have also been associated with changes in bone metabolism and progressive bone loss. The objective of this literature review is to examine the impact of bariatric surgery on bone and its main metabolic links, and to analyze the latest findings regarding the risk of fracture among patients submitted to bariatric surgery.

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“…Recent research indicates a decrease in bone mineral density and bone mineral content (by DEXA scan) and therefore deterioration of bone quality after bariatric surgery [97]. Researchers suggest that bariatric surgery may result in bone loss due to potential vitamin D deficiency, mechanical unloading from weight loss, and changed hormonal secretion such as reduced leptin and estrogen in perimenopausal women [98].…”

Section: Menopause and Osteoporosismentioning

confidence: 99%

“…While there is more evidence for increased risk of osteoporosis after Roux-en-Y gastric bypass than after sleeve gastrectomy, initial research indicates that there is no significant difference [97]. Roux-en-Y gastric bypass is suggested to be involved in impaired absorption of calcium and vitamin D. As a result, secondary hyperparathyroidism accompanied by increased degradation of bone material may occur [99].…”

Section: Menopause and Osteoporosismentioning

confidence: 99%

“…Roux-en-Y gastric bypass is suggested to be involved in impaired absorption of calcium and vitamin D. As a result, secondary hyperparathyroidism accompanied by increased degradation of bone material may occur [99]. The greatest amount of bone loss takes place within the axial skeleton, such as spine and ribs, an area that is particularly vulnerable even before bariatric surgery [97].…”

Section: Menopause and Osteoporosismentioning

confidence: 99%

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Review: Sex-Specific Aspects in the Bariatric Treatment of Severely Obese Women

Jäger

Wolicki

Spohnholz

et al. 2020

IJERPH

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This systematic literature review aims to point out sex-specific special features that are important in the bariatric treatment of women suffering from severe obesity. A systematic literature search was carried out according to Cochrane and Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) guidelines. After the literature selection, the following categories were determined: sexuality and sexual function; contraception; fertility; sex hormones and polycystic ovary syndrome; menopause and osteoporosis; pregnancy and breastfeeding; pelvic floor disorders and urinary incontinence; female-specific cancer; and metabolism, outcome, and quality of life. For each category, the current status of research is illuminated and implications for bariatric treatment are determined. A summary that includes key messages is given for each subsection. An overall result of this paper is an understanding that sex-specific risks that follow or result from bariatric surgery should be considered more in aftercare. In order to increase the evidence, further research focusing on sex-specific differences in the outcome of bariatric surgery and promising treatment approaches to female-specific diseases is needed. Nevertheless, bariatric surgery shows good potential in the treatment of sex-specific aspects for severely obese women that goes far beyond mere weight loss and reduction of metabolic risks.

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Determining changes in bone metabolism after bariatric surgery in postmenopausal women

Cited by 14 publications

References 28 publications

The role of obesity and bariatric surgery-induced weight loss in breast cancer

The role of obesity and bariatric surgery-induced weight loss in breast cancer

The Impact of Bariatric Surgery on Bone Health: State of the Art and New Recognized Links

Review: Sex-Specific Aspects in the Bariatric Treatment of Severely Obese Women

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