Determination the active compounds of herbal preparation by UHPLC–MS/MS and its application on the preclinical pharmacokinetics of pure ephedrine, single herbal extract of Ephedra , and a multiple herbal preparation in rats

Comparative pharmacokinetics of four active components on normal and diabetic rats after oral administration of Gandi capsules

“…Thus, it is better to investigate the herbal compatibility mechanism of multiple components or the whole prescription rather than single herbs or single compound. 18,19 Some articles have reported about the in vivo process of baicalin, wogonoside, wogonin, and loganin respectively or in other compound preparations. [20][21][22][23] However, few analytical methods were developed for simultaneous determination of the four compounds in rat plasma and to describe the prole of Gandi capsule in vivo aer oral administration.…”

Quantification of 10 bioactive components of Yazhangsan in rat plasma by LC–MS/MS and its application

“…Ephedrine and pseudoephedrine are stereoisomers, and they generally have similar retention characteristics. In some reports on the pharmacokinetics of EH, only ephedrine was considered (Wang, Chiang, Lu, & Tsai, 2016; Yan, Fu, Wang, & Ma, 2015), which is unreasonable. In this research, ephedrine and pseudoephedrine could be completely separated within 8.5 min.…”

Chinese herbal medicine for acute upper respiratory tract infections and reproductive safety: A systematic review

“…Ma-xing-shi-gan-tang (MXSGT) is a decoction consisting of Herba Ephedra (Ma-huang), Semen Armeniacae Amarum (Ku-xin-ren), Radix Glycyrrhizae (Gan-cao), and Gypsum Fibrosum (Shi-gao). Although MXSGT and Ma-huang-tang (MHT) differ in only one herb, both are conventional formulations for sweating, asthma, and febrile diseases such as influenza-like illness (31,32). The corresponding "syndromes" (exogenous diseases) they treat according to traditional Chinese medicine (TCM) differ substantially.…”