Determination of Zinc in Serum and Urine during Pregnancy In Colombian Women of Low Socioeconomic Level By Colorimetric Method using Zincon

Zapata, Carmiña Lucía Vargas; Coronado-Reyes, Sergio; Santiago, Fredis Gonzales; Garcia-Solano, Emilse; Muñoz-Salas, Karen; Abdala-Vargas, Nadin J.

doi:10.1096/fasebj.29.1_supplement.761.7

Cited by 1 publication

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“…As shown in Figure 2 g, after introducing the UZn solution to the surface of the modified sensing platform, the fraction of N and S groups is dramatically reduced, indicating that the metal receptors (zincon) on the surface of the modified sensing platform interacted with the target (UZn) ( Figure 2 h,i). 39 , 72 , 73 Collectively, data from SEM and EDX successfully validate the porous structure of the modified CA/r-GO layer and the interaction between zinc oxide and UZn.…”

Section: Resultsmentioning

confidence: 70%

“…As shown in Figure 2g, after introducing the UZn solution to the surface of the modified sensing platform, the fraction of N and S groups is dramatically reduced, indicating that the metal receptors (zincon) on the surface of the modified sensing platform interacted with the target (UZn) (Figure 2h,i). 39,72,73 Collectively, data from SEM and EDX successfully validate the porous structure of the modified CA/r-GO layer and the interaction between zinc oxide and UZn. Atomic force microscopy (AFM) is employed to scrutinize the surface morphology postzincon modification and subsequent exposure to UZn (Figure S3).…”

Section: Morphology Characterizationmentioning

confidence: 71%

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Rapid Near-Patient Impedimetric Sensing Platform for Prostate Cancer Diagnosis

Dehghani,

Karthikeyan,

Tajabadi

et al. 2024

ACS Omega

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With the global escalation of concerns surrounding prostate cancer (PCa) diagnosis, reliance on the serologic prostatespecific antigen (PSA) test remains the primary approach. However, the imperative for early PCa diagnosis necessitates more effective, accurate, and rapid diagnostic point-of-care (POC) devices to enhance the result reliability and minimize diseaserelated complications. Among POC approaches, electrochemical biosensors, known for their amenability and miniaturization capabilities, have emerged as promising candidates. In this study, we developed an impedimetric sensing platform to detect urinary zinc (UZn) in both artificial and clinical urine samples. Our approach lies in integrating label-free impedimetric sensing and the introduction of porosity through surface modification techniques. Leveraging a cellulose acetate/reduced graphene oxide composite, our sensor's recognition layer is engineered to exhibit enhanced porosity, critical for improving the sensitivity, capture, and interaction with UZn. The sensitivity is further amplified by incorporating zincon as an external dopant, establishing highly effective recognition sites. Our sensor demonstrates a limit of detection of 7.33 ng/mL in the 0.1−1000 ng/mL dynamic range, which aligns with the reference benchmark samples from clinical biochemistry. Our sensor results are comparable with the results of inductively coupled plasma mass spectrometry (ICP-MS) where a notable correlation of 0.991 is achieved. To validate our sensor in a real-life scenario, tests were performed on human urine samples from patients being investigated for prostate cancer. Testing clinical urine samples using our sensing platform and ICP-MS produced highly comparable results. A linear correlation with R 2 = 0.964 with no significant difference between two groups (p-value = 0.936) was found, thus confirming the reliability of our sensing platform.

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Section: Resultsmentioning

confidence: 70%

“…As shown in Figure 2g, after introducing the UZn solution to the surface of the modified sensing platform, the fraction of N and S groups is dramatically reduced, indicating that the metal receptors (zincon) on the surface of the modified sensing platform interacted with the target (UZn) (Figure 2h,i). 39,72,73 Collectively, data from SEM and EDX successfully validate the porous structure of the modified CA/r-GO layer and the interaction between zinc oxide and UZn. Atomic force microscopy (AFM) is employed to scrutinize the surface morphology postzincon modification and subsequent exposure to UZn (Figure S3).…”

Section: Morphology Characterizationmentioning

confidence: 71%