Determination of vitality of liver lesions by alveolar echinococcosis

Kaltenbach, Tanja; Graeter, Tilmann; Mason, Richard; Kratzer, Wolfgang; Oeztuerk, Suemeyra; Haenle, Mark Martin; Gruener, Beate; Gottstein, M.

doi:10.3413/nukmed-0670-14-05

Cited by 21 publications

(4 citation statements)

References 18 publications

(20 reference statements)

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“…and Li et al . also made quantitative comparisons between FDG uptake and contrast-enhanced ultrasonography in AE lesions 26 , 30 . Moreover, Azizi et al .…”

Section: Discussionmentioning

confidence: 99%

“…Based on the Kodama classification for MRI data, a comparative study between PET/CT and MRI showed that the presence of microcysts was associated with a significant increase in the metabolic activity detected with PET/CT 28 , 33 . Recent studies that compared contrast-enhanced ultrasonography with 18F-FDG PET/CT have shown a good correlation between FDG uptake and perilesional vascularization 26 , 30 , 31 . In cystic echinococcosis (CE), morphological findings with imaging corresponded to disease activity and could be used to manage treatment 35 .…”

Section: Introductionmentioning

confidence: 99%

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Hepatic alveolar echinococcosis: correlation between computed tomography morphology and inflammatory activity in positron emission tomography

Graeter

Eberhardt

Shi

et al. 2020

Sci Rep

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Positron emission tomography-computed tomography (PET-CT) with 18F-fluorodesoxyglucose (FDG) is the imaging modality of choice for assessing inflammation surrounding hepatic alveolar echinococcosis (AE) lesions. This study is the first to evaluate FDG uptake in hepatic AE (n = 51) based on the standardized uptake value (SUV) and to correlate the SUVs with primary morphology and calcification patterns, based on the Echinococcus multilocularis Ulm Classification for Computed-Tomography (EMUC-CT). Our results show that the SUVs were increased for lesions with EMUC-CT types I-IV primary morphology, compared to the surrounding healthy liver tissue (SUV = 2.5 ± 0.4; p < 0.05). Type IV lesions included, by far, the highest number of PET-negative lesions. A comparison of lesions with different primary morphologies showed clear differences. The highest SUVs were found for types I and III, and the lowest was found for type IV. Type IV lesions (SUV, 3.8 ± 1.5) showed significantly lower uptake compared to type I (SUV, 6.9 ± 3.5; p = 0.030) and type III (SUV, 7.4 ± 3.9; p = 0.031) lesions. For type II lesions, the results showed only a statistical trend (SUV, 6.1 ± 3.1; p = 0.073). Due to the small number of cases, an evaluation of type V (n = 1) lesions was not possible. The different SUVs of lesions with different primary morphologies, particularly the lower FDG uptake observed in type IV lesions, suggested that these SUVs might reflect different stages of the disease. prevalence. Alveolar echinococcosis (AE) is a dangerous zoonosis caused by the fox tapeworm, Echinococcus multilocularis. E. multilocularis is predominantly found in the cooler, temperate latitudes of the northern hemisphere 1,2. Europe, particularly southern Germany, eastern France, northern Switzerland, and western Austria, are heavily populated with the parasite 1-3. Outside central Europe, many human cases of AE have been found in China, particularly in the Tibetan plateau, and in Russia, particularly Siberia 1,2,4,5. Most human cases of AE were reported in China 1,6-10. General clinical picture and diagnosis. In over 98 percent, the liver is the organ most affected by AE.

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“…and Li et al . also made quantitative comparisons between FDG uptake and contrast-enhanced ultrasonography in AE lesions 26 , 30 . Moreover, Azizi et al .…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hepatic alveolar echinococcosis: correlation between computed tomography morphology and inflammatory activity in positron emission tomography

Graeter

Eberhardt

Shi

et al. 2020

Sci Rep

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“…Jiang et al 8 showed that angiogenesis could be used as an important indicator for evaluating the biological activity of AE. Some scholars have used contrast-enhanced ultrasound 24,25 and Revolution CT total liver perfusion 26 to evaluate angiogenesis and assess HAE biological activity. Ultrasound is the first choice in HAE evaluation, but it is limited in CAE because of the influence of the skull.…”

Section: Discussionmentioning

confidence: 99%

The Significance of Perfusion-Weighted Magnetic Resonance Imaging in Evaluating the Pathological Biological Activity of Cerebral Alveolar Echinococcosis

Wang

Gao

Rong³

et al. 2021

J Comput Assist Tomogr

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Objectives: This study aimed to evaluate the value of perfusion-weighted magnetic resonance imaging (MR-PWI) in assessing cerebral alveolar echinococcosis (CAE) biological activity.Methods: Totally, 15 cases of CAE patients who underwent surgery were enrolled. The MR-PWI perfusion parameters were measured and compared. Results:The MR-PWI perfusion parameters cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time were different among different areas. Their values were in the descending order of lesion marginal area > contralateral normal brain area > lesion center area. However, time-to-peak value was in the ascending order of lesion marginal area < contralateral normal brain area < lesion center area. Spearman correlation analysis showed that CBF and CBV at the edge of the lesion were significantly positively correlated with microvessel density. Moreover, CBF and CBV at the edge of the lesion were also significantly positively correlated with maximum standardized uptake value.Conclusions: Perfusion-weighted magnetic resonance imaging can be used to dynamically reflect the neovascularization of CAE lesions and may have a good application prospect in evaluating the biological activity of CAE.

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“…Echinococcus multilocularis eggs enter the intestinal tract of the intermediate host and hatch, reaching the liver through the portal vein and lymphatic vessels [17,18]. The larvae of E. multilocularis grow in an in ltrative manner in the liver, gradually invading the normal liver tissue and the surrounding blood and bile ducts through small vesicles.…”

Section: Pathological and Physiological Basis Of Ceus In The Of Haementioning

confidence: 99%

Diagnostic accuracy of contrast-enhanced ultrasound for hepatic alveolar echinococcosis

Liu,

Yang,

et al. 2024

Preprint

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Background: To evaluate the accuracy of contrast-enhanced ultrasound in the diagnosis of hepatic alveolar echinococcosis. Methods: This study included 148 consecutive patients with suspected HAE who visited the First Affiliated Hospital of Xinjiang Medical University between January 2013 and February 2023. They underwent both routine ultrasound and contrast-enhanced ultrasound examinations, and the contrast-enhanced ultrasound results of all cases were compared with those of the gold standard, postoperative pathology. We evaluated date such as sensitivity, specificity of contrast-enhanced ultrasound in the diagnosis of hepatic alveolar echinococcosis. The receiver operating characteristic curve was drawn and the area under curve of the subjects calculated. The area under curve was used to evaluate the diagnostic efficiency of contrast-enhanced ultrasound. Results: Of the148 patients with suspected hepatic alveolar echinococcosis, 83 were female and 65 males, with an average age of 38 ± 13 years (range, 18–74 years). Pathological diagnoses showed that 139 patients had hepatic alveolar echinococcosis; 137 cases were diagnosed correctly with contrast-enhanced ultrasound, with a diagnostic accuracy of 92.56% (137/148), sensitivity of 94.24% (131/139), specificity of 66.66% (6/9), positive predictive value of 97.76% (131/134), negative predictive value of 42.85% (6/14), positive likelihood ratio of 2.82, and negative likelihood ratio of 0.09 (6/14). The area under curve under the receiver operating characteristic curve for contrast-enhanced ultrasound was 0.805. Conclusions: The diagnostic accuracy of contrast-enhanced ultrasound for hepatic alveolar echinococcosis is 92.56%.

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Determination of vitality of liver lesions by alveolar echinococcosis

Cited by 21 publications

References 18 publications

Hepatic alveolar echinococcosis: correlation between computed tomography morphology and inflammatory activity in positron emission tomography

Hepatic alveolar echinococcosis: correlation between computed tomography morphology and inflammatory activity in positron emission tomography

The Significance of Perfusion-Weighted Magnetic Resonance Imaging in Evaluating the Pathological Biological Activity of Cerebral Alveolar Echinococcosis

Diagnostic accuracy of contrast-enhanced ultrasound for hepatic alveolar echinococcosis

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