Determination of vertebral endplate deformation under load using micro-computed tomography

Hulme, Paul A.; Ferguson, Stephen J.; Boyd, Steven K.

doi:10.1016/j.jbiomech.2007.07.018

Cited by 25 publications

(21 citation statements)

References 46 publications

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“…The difference between day 1 and day 2 endplate deformation, defined by the RMS error [13], was 0.030 mm, which is the effective precision of the protocol [18], compared with an average deformation of 0.084 ± 0.045 mm and maximum Deformation of the adjacent vertebrae…”

Section: Deformation Of the Control Fsumentioning

confidence: 96%

“…Regional measures of BV/TV have been shown to have a better correlation with vertebral fracture strength than traditional BMD assessment [18]. All parameters for scanning remained equivalent to those described above, except the integration time could be reduced to 200 ms, reducing the scan time for the entire specimen to less than 30 min.…”

Section: Cement Augmentationmentioning

confidence: 99%

“…Bone volume compared with the total vertebral volume (BV/TV) was determined from micro-CT scans performed in air, using a technique we have previously described [18]. Regional measures of BV/TV have been shown to have a better correlation with vertebral fracture strength than traditional BMD assessment [18].…”

Section: Cement Augmentationmentioning

confidence: 99%

“…Changes in loading, due to cement augmentation, will be evident in altered endplate behavior, which was measured using a non-invasive in situ, microcomputed tomography (micro-CT) method [18]. The specific aim of this repeated measures, in vitro, biomechanical study was to determine the effect of cement augmentation on endplate deformation of the adjacent and augmented vertebrae.…”

Section: Introductionmentioning

confidence: 99%

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Differences in endplate deformation of the adjacent and augmented vertebra following cement augmentation

et al. 2009

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Section: Deformation Of the Control Fsumentioning

confidence: 96%

Section: Cement Augmentationmentioning

confidence: 99%

Section: Cement Augmentationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Differences in endplate deformation of the adjacent and augmented vertebra following cement augmentation

et al. 2009

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“…Void growth and crack growth in textile composite specimens loaded in thickness direction are studied in [17]. Apart from the composite field, in situ CT is additionally used in manufacturing engineering [19] and in biomechanics [20] as well as to quantify damage in alloys [21] and foams [22].…”

Section: Introductionmentioning

confidence: 99%

A quantitative comparison of the capabilities of in situ computed tomography and conventional computed tomography for damage analysis of composites

Böhm

Stiller

Behnisch

et al. 2015

Composites Science and Technology

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Quantitative, 3D Visualization of the Initiation and Progression of Vertebral Fractures Under Compression and Anterior Flexion

Jackman

Hussein

Curtiss

et al. 2015

Journal of Bone and Mineral Research

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The biomechanical mechanisms leading to vertebral fractures are not well understood. Clinical and laboratory evidence suggests that the vertebral endplate plays a key role in failure of the vertebra as a whole, but how this role differs for different types of vertebral loading is not known. Mechanical testing of human thoracic spine segments, in conjunction with time-lapsed micro–computed tomography, enabled quantitative assessment of deformations occurring throughout the entire vertebral body under axial compression combined with anterior flexion (“combined loading”) and under axial compression only (“compression loading”). The resulting deformation maps indicated that endplate deflection was a principal feature of vertebral failure for both loading modes. Specifically, the onset of endplate deflection was temporally coincident with a pronounced drop in the vertebra’s ability to support loads. The location of endplate deflection, and also vertebral strength, were associated with the porosity of the endplate and the microstructure of the underlying trabecular bone. However, the location of endplate deflection and the involvement of the cortex differed between the two types of loading. Under the combined loading, deflection initiated, and remained the largest, at the anterior central endplate or the anterior ring apophysis, depending in part on health of the adjacent intervertebral disc. This deflection was accompanied by outward bulging of the anterior cortex. In contrast, the location of endplate deflection was more varied in compression loading. For both loading types, the earliest progression to a mild fracture according to a quantitative morphometric criterion occurred only after much of the failure process had occurred. The outcomes of this work indicate that for two physiological loading modes, the vertebral endplate and underlying trabecular bone are critically involved in vertebral fracture. These outcomes provide a strong biomechanical rationale for clinical methods, such as algorithm-based qualitative (ABQ) assessment, that diagnose vertebral fracture on the basis of endplate depression.

show abstract

Determination of vertebral endplate deformation under load using micro-computed tomography

Cited by 25 publications

References 46 publications

Differences in endplate deformation of the adjacent and augmented vertebra following cement augmentation

Differences in endplate deformation of the adjacent and augmented vertebra following cement augmentation

A quantitative comparison of the capabilities of in situ computed tomography and conventional computed tomography for damage analysis of composites

Quantitative, 3D Visualization of the Initiation and Progression of Vertebral Fractures Under Compression and Anterior Flexion

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