Determination of Urotensin Ii Levels Before and After Lsg in Patients With Obesity

Abstract

Purpose The goal of this study is to measure and compare the levels of UII in adipose tissue and serum in obese and non-obese individuals. Methods This study is to measure and compare the levels of UII in adipose tissue and serum in obese and non-obese individuals. Blood samples taken from clinically severe patients with obesity before sleeve gastrectomy and adipose tissue samples taken during surgery were examined. UII and biochemical parameters were analyzed on blood samples taken from patients whose BMI decreased to normal limits after surgery (6 months later) and on adipose tissue from people with normal BMI. Results The serum UII levels of the POSTOP group decline compared to the PREOP. The tissue UII levels in the PREOP group was statistically significantly higher than in Group C. It was observed that the serum UII levels of the patients who achieved normal BMI with sleeve gastrectomy were lower than before the surgery. Individuals with serum UII levels below 46.88 and tissue UII levels below 202.87 were found to be unsuitable for sleeve gastrectomy, whereas those with values above this cut off were found to be more suitable. Conclusions The decrease in UII levels in individuals with normal BMI after LSG surgery and the difference in UII between individuals with normal BMI and obese indicate that UII has an important role in obesity.