Determination of trace elements in biological fluids

Ivanenko, N. B.; Ганеев, А. А.; Solovyev, Nikolay; Москвин, Л. Н.

doi:10.1134/s1061934811090036

Cited by 45 publications

(56 citation statements)

References 105 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This step takes about 14 hours. The microwave technology has been already used for mineralization of biological samples [14] [15]. In this paper, the mineralization step with microwave oven was improved in order to be adjusted to the subsequent step of actinides extraction on calixarene columns.…”

Section: Optimization Of Mineralization Stepmentioning

confidence: 99%

Operational Protocol for Detection of Contamination by Actinides U, Pu and Am in Urine Using Calixarene Columns: From Mineralization to ICP-MS Measurement

Bouvier‐Capely¹,

Legrand²,

Sylvain³

et al. 2017

AJAC

View full text Add to dashboard Cite

Individual monitoring of workers exposed to the risk of intake of actinides requires suitable methods for measuring low level of excreted activity. The current protocols used for actinides analysis in bioassay are usually complicated and highly time consuming. In this work, a protocol based on the microwave digestion of urines followed by the separation of actinides using calix[6]arene-based chromatography columns and their measurement by a quadrupole ICP-MS is developed and validated, for the first time, on urine samples containing the three actinides, U, Pu and Am. With this protocol, the total analysis time is about 2 days, including the mineralization of urine and the chromatographic separation of actinides. Detection limits of actinides in urine are determined and compared to those obtained after "dilute and shoot" ICP-MS analysis or after alpha spectrometry measurement.

show abstract

Section: Optimization Of Mineralization Stepmentioning

confidence: 99%

Operational Protocol for Detection of Contamination by Actinides U, Pu and Am in Urine Using Calixarene Columns: From Mineralization to ICP-MS Measurement

Bouvier‐Capely¹,

Legrand²,

Sylvain³

et al. 2017

AJAC

View full text Add to dashboard Cite

show abstract

“…Поэтому для увеличения эффективности пиролиза использовали модификатор матрицы, раствор нитрата палладия (Pd(NO 3 ) 2 ), который не только стабилизирует элементы в атомизаторе, но и способствует эффективному окислению органической матрицы при умеренных температурах пиролиза [4].…”

Section: методикаunclassified

“…Экспрессность анализа, характерная для методик прямого определения, важна, в первую очередь, при срочной диагностике острых отравлений и текущем мониторинге состояния пациентов. Более того, стадия подготовки пробы к анализу является одной из наиболее критических с точки зрения правильности измерений [3,4]. Исключение стадии минерализации проб крови из аналитического процесса не только позволяет избежать появления значимых погрешностей, но и повышает чувствительность определения элементов.…”

unclassified

Determination of Al, Be, Cd, Co, Cr, Mn, Ni, Pb, Se and Tl in whole blood by atomic absorption spectrometry without preliminary sample digestion

Nb¹,

Aa²,

Nd³

et al. 2014

BIOMED KHIM

View full text Add to dashboard Cite

show abstract

“…A review of trace elements in biological fluids by Ivanenko et al [27] lists four published methods [26,28–30] of whole blood analysis by quadrupole ICP-MS with a collision or reaction cell used to measure at least one of the elements here. Four other publications were identified [22,31–33] in the literature as comparable to our method.…”

Section: Introductionmentioning

confidence: 99%

Analysis of whole human blood for Pb, Cd, Hg, Se, and Mn by ICP-DRC-MS for biomonitoring and acute exposures

Jones

Jarrett

Tevis

et al. 2017

Talanta

View full text Add to dashboard Cite

We improved our inductively coupled plasma mass spectrometry (ICP-MS) whole blood method [1] for determination of lead (Pb), cadmium (Cd), and mercury (Hg) by including manganese (Mn) and selenium (Se), and expanding the calibration range of all analytes. The method is validated on a PerkinElmer (PE) ELAN® DRC II ICP-MS (ICP-DRC-MS) and uses the Dynamic Reaction Cell (DRC) technology to attenuate interfering background ion signals via ion-molecule reactions. Methane gas (CH4) eliminates background signal from 40Ar2+ to permit determination of 80Se+, and oxygen gas (O2) eliminates several polyatomic interferences (e.g. 40Ar15N+, 54Fe1H+) on 55Mn+. Hg sensitivity in DRC mode is a factor of two higher than vented mode when measured under the same DRC conditions as Mn due to collisional focusing of the ion beam. To compensate for the expanded method’s longer analysis time (due to DRC mode pause delays), we implemented an SC4-FAST autosampler (ESI Scientific, Omaha, NE), which vacuum loads the sample onto a loop, to keep the sample-to-sample measurement time to less than 5 min, allowing for preparation and analysis of 60 samples in an 8-h work shift. The longer analysis time also resulted in faster breakdown of the hydrocarbon oil in the interface roughing pump. The replacement of the standard roughing pump with a pump using a fluorinated lubricant, Fomblin®, extended the time between pump maintenance. We optimized the diluent and rinse solution components to reduce carryover from high concentration samples and prevent the formation of precipitates. We performed a robust calculation to determine the following limits of detection (LOD) in whole blood: 0.07 μg dL−1 for Pb, 0.10 μg L−1 for Cd, 0.28 μg L−1 for Hg, 0.99 μg L−1 for Mn, and 24.5 μg L−1 for Se.

show abstract

Determination of trace elements in biological fluids

Cited by 45 publications

References 105 publications

Operational Protocol for Detection of Contamination by Actinides U, Pu and Am in Urine Using Calixarene Columns: From Mineralization to ICP-MS Measurement

Operational Protocol for Detection of Contamination by Actinides U, Pu and Am in Urine Using Calixarene Columns: From Mineralization to ICP-MS Measurement

Determination of Al, Be, Cd, Co, Cr, Mn, Ni, Pb, Se and Tl in whole blood by atomic absorption spectrometry without preliminary sample digestion

Analysis of whole human blood for Pb, Cd, Hg, Se, and Mn by ICP-DRC-MS for biomonitoring and acute exposures

Contact Info

Product

Resources

About