Determination of Total Phenolic Content, Total Flavonoid Content, and Antimutagenic Activity of Ethanol Extract Nanoparticles of Rhaphidophora Pinnata (L.F) Schott Leaves

Sumaiyah,; Masfria,; Dalimunthe, Aminah

doi:10.31788/rjc.2018.1122068

Cited by 12 publications

(11 citation statements)

References 9 publications

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“…Secondary metabolites in the methanol extract of non-geothermal leaves are not flavonoids. Flavonoid compounds in plants are a natural source of antioxidants that can inhibit the development of several types of diseases in humans, such as cardiovascular diseases and cancer 17 . Laban leaves contain flavonoids, saponins, tannins, triterpenoids/steroids, and glycosides 6 .…”

Section: Organoleptic Testmentioning

confidence: 99%

Identification of Secondary Metabolite of Laban Leaf Extract (Vitex Pinnata L) From Geothermal Areas and Non-Geothermal of Agam Mountains in Aceh Besar, Aceh Province, Indonesia

Nuraskin¹,

Marlina²,

Idroes³

et al. 2020

RJC

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The purpose of this study was to analyze the comparison of the number of Laban leaf extracts from geothermal and non-geothermal regions, calculating yield values, and identifying active compounds in Laban leaves taken from geothermal and non-geothermal regions in Aceh Besar, Aceh Province. The study was started by extracting Laban leaves by maceration method, using n-hexane, ethyl acetate and methanol for 3 x 24 hours. Then the extract was concentrated with a Rotary evaporator, calculated yield value, and phytochemical test. The results of the identification showed that there were differences in extract weight and weight of yields in the leaves in geothermal and non-geothermal regions. In n-hexane extract, the weight difference of extract was 37.6 g, and the difference in weight of the yield was 1.25%. In ethyl acetate extract the extract weight difference was 98.57 g, and the weight difference in yield was 3.28%. Methanol extract weight difference is 427.33g, and the difference in weight of the yield was 11.59%. The biggest difference is found in methanol extract.

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Section: Organoleptic Testmentioning

confidence: 99%

Identification of Secondary Metabolite of Laban Leaf Extract (Vitex Pinnata L) From Geothermal Areas and Non-Geothermal of Agam Mountains in Aceh Besar, Aceh Province, Indonesia

Nuraskin¹,

Marlina²,

Idroes³

et al. 2020

RJC

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“…The data were expressed as Mean ± SEM and analyzed using one-way ANOVA followed by post hoc Tukey to find the different variables [8]. Differences were considered as statistically significant at p < 0.05 when compared with control.…”

Section: R Pinnata Leaves Were Obtained Frommentioning

confidence: 99%

“…The previous research showed that the leaf performs cytotoxicity activity with brine shrimp test method and MTT assays. R. pinnata also possess antioxidant activity with 1,1-diphenyl-2-pikrihidrazil, which is an active anticancer toward cell MCF-7 and is a antimutagenic [7], [8]. The previous study showed that R. pinnata had the potential to be an anti-cancer and hence possess the anti-inflammatory and analgetic activity.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Activity of Rhaphidophora pinnata (L.F) Schott Leaf Extract

Sumaiyah¹,

Masfria²,

Dalimunthe³

2020

Open Access Maced J Med Sci

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BACKGROUND: Cancer growth is influenced by many factors and in general it is an interaction between gene factors and environmental factors, especially the microenvironment that exists around cancer. The inflammatory response plays a decisive role in various stages of cancer growth. AIM: The aim of this study was to determine the anti-inflammatory activity of ethanol extract of Rhaphidophora pinnata leaves. METHODS: R. pinnata leaf extract was obtained by percolation method using 96% ethanol as the solvent at room temperature. Anti-inflammatory activity was determined based on the paw edema method. Thirty male albino mice were treated orally with sodium carboxyl cellulose suspension (as negative control group), R. pinnata leaf extract (35, 70, 140, and 280 mg/kgBW), and diclofenac (as positive control group), 60 min before 0.2 mL 1% carrageenan injection. The paw thickness was measured using plethysmometer before injecting the carrageenan and after 1, 2, 3, 4, 5, and 6 h. RESULTS: The subplantar injection of carrageenan caused a time-dependent paw edema in the mice. Oral administration of R. pinnata leaf extract inhibited paw swelling at 1, 2, 3 4, 5, and 6 h after carrageenan injection. R. pinnata leaf extracts doses of 35, 70, 140, and 280 mg/kgBW gave a percentage inhibition of 56.56%, 56.18%, 62.77%, and 49.30%, respectively. The effective dose of R. pinnata leaf extract as an anti-inflammatory was 140 mg/kgBW. CONCLUSION: Ethanol extract of R. pinnata leaf has anti-inflammatory activity in male albino mice.

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“…9 The products which are developed from the natural plants are a good source of new antimicrobials owes to low toxicity cause minimal environmental pollution and have a low risk of development of resistance by pathogenic microorganism. 10 Some plants possess antimutagenic activity due to the presence of its total phenol and flavonoid content 11 and certain aquatic plant-like watercress contains a promising level of pharmaceutical and nutritional sources. 12 Fig.…”

Section: Introductionmentioning

confidence: 99%

PHYTOCHEMICAL SCREENING AND ANTIMICROBIAL EVALUATION OF ETHANOLIC-AQUA EXTRACT OF Stachytarpheta jamaicensis (L.) VAHL LEAVES AGAINST SOME SELECTED HUMAN PATHOGENIC BACTERIA

Thangiah¹

2019

RJC

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The study was carried out to evaluate phytochemical and antibacterial effect of ethanolic-aqua extract of Stachytarpheta jamaicensis leaves against four selected pathogenic bacterial organisms.Phytochemical analysis revealed the presence of secondary metabolites such as tannins, saponins, terpenoids, flavonoids, phenols, alkaloids, steroids and glycoside.The zones of inhibitions were 11.503 ± 0.005 for B. cereus, 10.766 ± 0.033 for S. typhi, 14.766 ± 0.0.033 for P. vulgaris and 13.566 ± 0.033 for S. pyogenes respectively. The zones of inhibitions of the microorganism such as B. cereus, P. vulgaris and S. pyogenes were larger than their positive control except S. typhi. Analysis of variance (ANOVA) showed that the organisms were significantly different in the zones of inhibition (p<0.05). The inhibition of the plant leaves extract to the growth of all the organisms greatly depicts the plant leaves to have great potential against diseases caused by the organisms. The overall therapeutic activities of the extract mighty be due to the presence of various phytoconstituents. Further research need to be done to prove their in vivo environment.

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Determination of Total Phenolic Content, Total Flavonoid Content, and Antimutagenic Activity of Ethanol Extract Nanoparticles of Rhaphidophora Pinnata (L.F) Schott Leaves

Cited by 12 publications

References 9 publications

Identification of Secondary Metabolite of Laban Leaf Extract (Vitex Pinnata L) From Geothermal Areas and Non-Geothermal of Agam Mountains in Aceh Besar, Aceh Province, Indonesia

Identification of Secondary Metabolite of Laban Leaf Extract (Vitex Pinnata L) From Geothermal Areas and Non-Geothermal of Agam Mountains in Aceh Besar, Aceh Province, Indonesia

Anti-Inflammatory Activity of Rhaphidophora pinnata (L.F) Schott Leaf Extract

PHYTOCHEMICAL SCREENING AND ANTIMICROBIAL EVALUATION OF ETHANOLIC-AQUA EXTRACT OF Stachytarpheta jamaicensis (L.) VAHL LEAVES AGAINST SOME SELECTED HUMAN PATHOGENIC BACTERIA

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