Determination of total avilamycin residues as dichloroisoeverninic acid in porcine muscle, fat, and liver by LC-MS/MS

Saito-Shida, Shizuka; Hayashi, Tomoko; Nemoto, Satoru; Akiyama, Hiroshi

doi:10.1016/j.foodchem.2018.01.003

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…[6][7][8][9] Traditional methods of detecting antibiotics include microbial inhibition, chromatography/mass spectrometry, and immunoassay techniques. [10][11][12] However, these methods suffer from drawbacks such as inaccuracy, time consumption, and high costs. Modern techniques like electrochemical sensing, Raman spectroscopy, and optical spectroscopy have been explored as alternatives.…”

Section: Introductionmentioning

confidence: 99%

Carbon within carbon: growth of excitation-independent CDs within functional mesoporous carbon towards detection and adsorption of a specific nitrofuran class of antibiotics

Yadav,

Choudhary,

Paital

2024

J. Mater. Chem. A

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Section: Introductionmentioning

confidence: 99%

Carbon within carbon: growth of excitation-independent CDs within functional mesoporous carbon towards detection and adsorption of a specific nitrofuran class of antibiotics

Yadav,

Choudhary,

Paital

2024

J. Mater. Chem. A

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“…Avilamycin is an orthosomycin family antibiotic derived from the fermentation products of Streptomyces viridochromogenes ( Mertz et al, 1986 ; Saito-Shida et al, 2018 ), including the major active factor avilamycin A and 15 other small factors ( JECFA, 2004 ). Avilamycin is one of the EU-approved antimicrobial agents in the feed industry and is currently only used in animals to control bacterial enteric infections and multidrug-resistant gram-positive bacteria ( Ho et al, 2013 ; Lv et al, 2013 ; OIE, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Optimal Regimens and Clinical Breakpoint of Avilamycin Against Clostridium perfringens in Swine Based on PK-PD Study

Huang¹,

Luo²,

Xu³

et al. 2022

Front. Pharmacol.

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Clostridium perfringens causes significant morbidity and mortality in swine worldwide. Avilamycin showed no cross resistance and good activity for treatment of C. perfringens. The aim of this study was to formulate optimal regimens of avilamycin treatment for C. perfringens infection based on the clinical breakpoint (CBP). The wild-type cutoff value (COWT) was defined as 0.25 μg/ml, which was developed based on the minimum inhibitory concentration (MIC) distributions of 120 C. perfringens isolates and calculated using ECOFFinder. Pharmacokinetics–pharmacodynamics (PK-PD) of avilamycin in ileal content were analyzed based on the high-performance liquid chromatography method and WinNonlin software to set up the target of PK/PD index (AUC0–24h/MIC)ex based on sigmoid Emax modeling. The PK parameters of AUC0–24h, Cmax, and Tmax in the intestinal tract were 428.62 ± 14.23 h μg/mL, 146.30 ± 13.41 μg/ml,, and 4 h, respectively. The target of (AUC0–24h/MIC)ex for bactericidal activity in intestinal content was 36.15 h. The PK-PD cutoff value (COPD) was defined as 8 μg/ml and calculated by Monte Carlo simulation. The dose regimen designed from the PK-PD study was 5.2 mg/kg mixed feeding and administrated for the treatment of C. perfringens infection. Five respective strains with different MICs were selected as the infection pathogens, and the clinical cutoff value was defined as 0.125 μg/ml based on the relationship between MIC and the possibility of cure (POC) following nonlinear regression analysis, CART, and “Window” approach. The CBP was set to be 0.25 μg/ml and selected by the integrated decision tree recommended by the Clinical Laboratory of Standard Institute. The formulation of the optimal regimens and CBP is good for clinical treatment and to control drug resistance.

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Design of ultrathin nanosheet subunits ZnIn2S4 hollow nanocages with enhanced photoelectric conversion for ultrasensitive photoelectrochemical sensing

Peng

Yang²,

Chen

et al. 2021

Biosensors and Bioelectronics

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Determination of total avilamycin residues as dichloroisoeverninic acid in porcine muscle, fat, and liver by LC-MS/MS

Cited by 6 publications

References 14 publications

Carbon within carbon: growth of excitation-independent CDs within functional mesoporous carbon towards detection and adsorption of a specific nitrofuran class of antibiotics

Carbon within carbon: growth of excitation-independent CDs within functional mesoporous carbon towards detection and adsorption of a specific nitrofuran class of antibiotics

Optimal Regimens and Clinical Breakpoint of Avilamycin Against Clostridium perfringens in Swine Based on PK-PD Study

Design of ultrathin nanosheet subunits ZnIn2S4 hollow nanocages with enhanced photoelectric conversion for ultrasensitive photoelectrochemical sensing

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