Determination of tin by the inverted-flame method.

Takahashi, Kazuhiro; Ogasawara, Ichiro; Nishikawa, Toshio; Ohyagi, Yoshihiko

doi:10.2116/bunsekikagaku.34.12_757

Cited by 3 publications

(2 citation statements)

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“…We have therefore developed a satisfactory method to determine these compounds in biological materials by gas chromatography with flame photometric detection Matsui, 1992, 1993a). Because the photometric detection mechanism is attributed to light emission of the excited organotin species in the detector flame (Aue and Flinn, 1977) and the light emission has a strong band head at 609.5 nm (Takahashi et al, 1985), the wavelength of 610 nm filter was used in these studies. The chromatographic peaks of the organotin compounds were well separated, and high sensitivity was achieved in this mode (the limits of detection were 3.0-4.4 pg as tin).…”

Section: Discussionmentioning

confidence: 99%

“…Because the light emission of the excited Sn-H molecules in the detector flame has a strong band head at 609.5 nm (Takahashi et al, 1985), we have developed a satisfactory method for measuring the concentrations of inorganic tin and phenyltin compounds (mono-, di-and triphenyltin) in biological materials by gas chromatography with tin-mode (610 nm filter) flame photometric detection Matsui, 1992, 1993a). The method was applied to study the metabolism of tetraphenyltin in rats in this paper.…”

Section: Determination Of Tin Compounds In Tissuementioning

confidence: 99%

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Metabolism of a tetraphenyltin compound in rats after a single oral dose

Ohhira

Matsui

2003

J of Applied Toxicology

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The metabolism of tetraphenyltin in rat liver and kidney has been examined. Tetraphenyltin and its metabolites in the tissue were determined periodically for 96 h after a single oral dose of 55.4 mg kg(-1) of tetraphenyltin by gas chromatography. The gas chromatographic method was able to determine simultaneously both inorganic tin and phenyltin compounds. Although initial (at 24 h) levels of tetraphenyltin in the liver approximated four times those in the kidneys, the levels of tetraphenyltin decreased more rapidly with time than those in the kidneys. These findings show that the tetraphenyltin accumulated more rapidly and highly in the liver, but was metabolized faster than that in the kidney. The levels of total tin in the liver 24 h after treatment were distinctly lower than those of di- or triphenyltin treatments in our previous studies and none of the animals showed characteristic symptoms. The toxic potencies of organotins generally correlate with accumulation of the chemicals. These results imply that the slight toxicities of tetraphenyltin might be due to the relatively low uptake of tin compounds after ingestion. The highest tin concentration among the metabolites of tetraphenyltin in the tissue, especially in liver, was observed as diphenyltin throughout the time period studied. These results suggest that part of the administered tetraphenyltin may cause some harmful effects as diphenyltin in rats, and this must be taken into consideration in toxicological research on tetraphenyltin.

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Section: Discussionmentioning

confidence: 99%

Section: Determination Of Tin Compounds In Tissuementioning

confidence: 99%