Determination of Thyreostats in Urine Using Supported Liquid Extraction and Mixed-Mode Cation-Exchange Solid-Phase Extraction: Screening and Confirmatory Methods

Tölgyesi, Ádám; Giri, Anupam; Barta, Enikő; McDonald, Thomas J.; Sharma, Virender K.

doi:10.1093/chromsci/bmy054

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…The acidic and neutral PhACs can be eluted selectively by organic solvents, meanwhile the basic PhACs are retained. Finally, the elution of basic PhACs provides visibly cleaner extracts in comparison to the phases with single interaction mode (Tolgyesi et al, 2018).…”

Section: Spe Optimisationmentioning

confidence: 99%

Spatiotemporal variations of pharmacologically active compounds in surface waters of a summer holiday destination

Maász

Mayer

Zrínyi

et al. 2019

Science of The Total Environment

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The release of pharmacologically active compounds (PhACs) into aquatic ecosystems poses an environmental risk resulting in a chronic exposure of non-target organisms. A great variety of PhACs, of generally low concentrations, and the complicated sample preparation, makes circumstantial the accurate detection and quantification. Additionally, there is little information published about the spatiotemporal variation of the PhAC load in a larger catchment area utilised for touristic purposes. In addition to the natural biotic and abiotic changes, the seasonal variation of tourism also has a dramatic impact on water quality and the natural ecosystem in larger catchment areas. Therefore, our aim was to develop a reliable solid-phase extraction (SPE)-supercritical fluid chromatography tandem mass spectrometry (SFC-MS/MS) method for simultaneous multi-residue analysis of drugs to reveal the spatiotemporal changes in the PhAC contaminations in the waters of an important touristic region, the catchment area of the largest shallow lake in Central Europe, Lake Balaton (Hungary). The environmental application of the developed method revealed 69 out of the traced 134 chemical compounds, including 15 PhACs, which were detected from natural waters for the first time. Wastewater treatment plant (WWTP) loads have a major role in the PhAC contamination of the studied area; at the same time, the mass tourism-induced PhAC contamination was also detectable. Furthermore, the impact of tourism was indicated by elevated concentrations of recreational substances (e.g., 3 caffeine and illicit drugs) in the touristic season affecting the water quality of this important summer holiday destination.

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Section: Spe Optimisationmentioning

confidence: 99%

Spatiotemporal variations of pharmacologically active compounds in surface waters of a summer holiday destination

Maász

Mayer

Zrínyi

et al. 2019

Science of The Total Environment

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Determination of Aminophosphonate Herbicides in Glutamate Loaded Spice Mix by LC-IDMS and Method Extension to Other Food Matrices

Tölgyesi¹,

Tóth²,

Farkas³

et al. 2022

Food Anal. Methods

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The accumulation of organophosphorus type herbicides has been observed worldwide in the environment (i.e. soil, water), together with their appearance in foods of plant origin. This paper reports a new liquid chromatography–isotope dilution–tandem mass spectrometric method (LC-IDMS) for the analysis of glufosinate (GLUF), glyphosate (GLY) and its main metabolite, aminomethylphosphonic acid (AMPA), in challenging food samples. Sample preparation is based on aqueous extraction with ethylenediaminetetraacetic acid solution, followed by solid-phase extraction (SPE) on mixed-mode cation exchange cartridges to remove matrix constituents before derivatization with 9-fluorenylmethoxycarbonyl chloride (FMOC-Cl). Derivatized samples were cleaned up on hydrophilic modified polymeric SPE cartridge. This two-step SPE supported sample preparation approach, and the LC-IDMS separation carried out in negative ionization mode resulted in fit-for-purpose recovery (81–118%) and precision (4–18%) in the validation of glutamate loaded spice mix, mushroom, maize and cherry samples. Amino acid content influencing FMOC derivatization efficiency was estimated with a HILIC-MS/MS setup. Multiple reaction monitoring (MRM) was assisted with high-resolution (QTOF) accurate mass data on the FMOC-derivatized GLUF, GLY and AMPA standards. The limit of quantification (LOQ) was 0.005 mg/kg for all the three analytes. The method was successfully applied on quality control samples (oat and arugula) with fit-for-purpose accuracy (99–120%) and on other nineteen real samples, where GLY and AMPA were detected in the range between 0.005 and 0.069 mg/kg.

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Polyethyleneimine-modified hybrid silica sorbent for hydrophilic solid-phase extraction of thyreostats in animal tissues

Wang

2018

Journal of Chromatography A

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Determination of Thyreostats in Urine Using Supported Liquid Extraction and Mixed-Mode Cation-Exchange Solid-Phase Extraction: Screening and Confirmatory Methods

Cited by 3 publications

References 21 publications

Spatiotemporal variations of pharmacologically active compounds in surface waters of a summer holiday destination

Spatiotemporal variations of pharmacologically active compounds in surface waters of a summer holiday destination

Determination of Aminophosphonate Herbicides in Glutamate Loaded Spice Mix by LC-IDMS and Method Extension to Other Food Matrices

Polyethyleneimine-modified hybrid silica sorbent for hydrophilic solid-phase extraction of thyreostats in animal tissues

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