Determination of thiocompounds by liquid chromatography with amperometric detection at a Nafion/indium hexacyanoferrate film modified electrode

Song, Zhijian; Sun, Wenliang; Zhang, Wen; Qi, Wen-yu; Jin, Litong; Yamamoto, Katsunobu; Tao, Shuguang; Jin, Jiye

doi:10.1016/s0003-2670(98)00799-5

Cited by 87 publications

(62 citation statements)

References 26 publications

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“…These techniques were high-performance liquid chromatographymass spectrometry (HPLC-MS) [19], liquid chromatography with UV detection [20], reverse-phase HPLC [21] and gas chromatography-mass spectrometry (GC-MS) [22]. Electrochemical methods using glassy carbon modified with thin film of polynuclear indium(III) hexacyanoferrate [23] and square wave voltammetry using a Pt microdisk [24] have been applied for the determination of MMI with micromolar detection limits.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Determination of Methimazole Using a Carbon Paste Electrode Modified with a Schiff Base Complex of Cobalt

Shahrokhian

Ghalkhani

2008

Electroanalysis

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The electrochemical behavior of methimazole, as an antithyroid agent, is investigated on the surface of a carbon-paste electrode modified with a newly synthesized Schiff base complex of cobalt. The prepared modified electrode showed an efficient catalytic role in the electrochemical oxidation of methimazole, leading to remarkable decrease in oxidation overpotential and enhancement of the kinetics of the electrode reaction. The mechanism of the electrocatalytic process on the surface of the modified electrode is analyzed by obtaining the cyclic voltammograms in various potential sweep rates and pHs of the buffer solutions. The differential pulse voltammetry is applied as a very sensitive analytical method for the determination of sub-micromolar amounts of methimazole. A linear dynamic range of 1 Â 10 À6 to 1 Â 10 À4 M with a detection limit of 5 Â 10 À7 M is resulted for methimazole. The modified electrode is successfully applied for the accurate determination of methimazole in pharmaceutical and clinical preparations. The linear range in calibration curves remains constant in addition to tablet preparations of methimazole and also in spiking to the synthetic human serum samples. In comparison to calibration curves in background buffer solution, the slope of the curves showed a variation less than 3% in determinations in background solutions of tablet and human synthetic serum samples. These results showed high efficiency of the Voltammetric procedure for accurate determination of methimazole in drug and clinical preparations. The modified electrode can be prepared very easy and renewed in its surface by simple polishing. The reproducibility of the electrode response, based on ten measurements during two month, was 3.2% for the slope of the calibration curve.

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Section: Introductionmentioning

confidence: 99%

Voltammetric Determination of Methimazole Using a Carbon Paste Electrode Modified with a Schiff Base Complex of Cobalt

Shahrokhian

Ghalkhani

2008

Electroanalysis

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“…Electrochemical determinations using metals particle-modified electrodes have been focused on. [20][21][22][23][24][25][26][27] On the other hand, it is also important to prepare an amperometric sensor for the measurement of hydrogen peroxide and cysteine. 28 In the paper, electrocatalytic oxidation for hydrogen peroxide and cysteine at Pt-CNT/GCE was investigated.…”

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confidence: 99%

Electrocatalytic Oxidation of Hydrogen Peroxide and Cysteine at a Glassy Carbon Electrode Modified with Platinum Nanoparticle-deposited Carbon Nanotubes

Tian

2005

ANAL. SCI.

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Dispersed metal particles exhibit excellent catalytic activity that closely relates to their minimized diameters. The micro and nano particles trend to have excellent quality in chemical and electrochemical reactions. For this purpose, metal particles have been successfully dispersed and decorated on some substrates such as carbon and conductive polymers to make catalyst. [1][2][3] It is essential to find ways to further reduce diameters of these metal particles to promote their catalytic activity. The diameters of nano particles vary with the medium and the substrates on which they are made. As one typical nano material, carbon nanotubes (CNT) whose diameters vary from 0.33 to less than 100 nanometers were made up with hexagonal lattices of carbon. Because of their characteristic electron conductivity valves, pore structures and absorption abilities they are fit for metal substrates. Various metals and alloys were deposited on them. [4][5][6][7][8][9] Electrodes modified with CNT and used to analyze biomolecules have received much interest. [10][11][12][13][14][15][16][17][18] However, no preparation of electrodes modified by nano metal particlesdecorated carbon nanotubes has been reported. In our research, a glassy carbon electrode modified with platinum nano particles decorated on carbon nanotubes (Pt-CNT/GCE) was developed. Carbon nanotubes decorated with platinum nano particles (Pt-CNT) were obtained by chemical method, 19 and then were immobilized on the surfaces of GCE electrodes. Electrochemical determinations using metals particle-modified electrodes have been focused on. [20][21][22][23][24][25][26][27] On the other hand, it is also important to prepare an amperometric sensor for the measurement of hydrogen peroxide and cysteine. 28 In the paper, electrocatalytic oxidation for hydrogen peroxide and cysteine at Pt-CNT/GCE was investigated. Due to the nano-sized platinum particles deposited on CNT, the currents at Pt-CNT/GCE were almost 3-times higher and the electrode reaction rates were obviously faster, compared with bare platinum electrode results. So, the Pt-CNT/GCE has high electro-catalytic activity, which is suitable for preparing enzyme electrodes with better sensitivity, repeatability and stability. Experimental Equipment and reagentsElectrochemical experiments were carried out using a CHI660B electrochemical workstation (CHI Instruments Inc., US). A glassy carbon electrode (φ = 2 mm) modified with Pt-CNT was used as the working electrode. A platinum wire and KCl saturated Ag/AgCl electrodes were employed as the counter electrode and a reference electrode, respectively. For comparison of the electro-catalytic activities, a bare Pt electrode (φ = 2 mm) was also used as a working electrode.Carbon nanotubes (inner φ = 4 -8 nm, outer φ = 10 -30 nm) were supplied by the Dept. of Materials, Zhejiang University; they were synthesized by Chemical Vapor Deposit method. 0.1 mol/L phosphate buffer solution (pH 7.0) was prepared by freshly distilled water. 10 mg/mL H2PtCl6 was made in 6 mol/L HCl solutions...

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“…5 So far, various analytical methods in TLC, 6 GC-MS, [7][8] HPLC-UV [9][10][11] or MS [12][13] and CE [14][15] have been described for the effectively monitoring MMZ in kinds of samples including urine, [7][8][9][10][11] plasma, 6 tissues 9,12-13 and serum. 15 Flow injection analysis, 15 electrochemical detec-tion [16][17][18] and molecularly imprinted polymer (MIP) 19 for MMZ are also developed. Among all of these methods, HPLC is the most commonly used method because it is sensitive and selective and it could be provided at a low level of MMZ, but it is expensive and not suitable for extensively prevalence.…”

Section: Introductionmentioning

confidence: 99%

Development of a Biomimetic Enzyme‐linked Immunosorbent Assay Method for the Determination of Methimazole in Urine Sample

Wang

Tang

Fang

et al. 2011

J Chinese Chemical Soc

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A fast and direct competitive biomimetic enzyme-linked immunosorbent assay (BELISA) method was developed for the determination of methimazole (MMZ) in urine sample based on a molecularly imprinted film as an artificial antibody. This is the first example to monitor methimazole with a direct competitive biomimetic enzyme-linked immunosorbent assay (BELISA) method. The imprinted film was directly synthesized on the well surface of MaxiSorp polystyrene 96-well plate and characterized. The results showed that it exhibited an antibody-like binding ability, rapid adsorption speed, high stability, which was particularly advantageous and suitable for BELISA development. The BELISA method established in this paper had a higher selectivity for MMZ than for the structurally related compounds and the IC 50 (calculated as the concentration giving 50% inhibition of color development) and the detection limit values under optimized experimental conditions were 70 ± 4 mg L -1 and 0.9 ± 0.04 mg L -1 , respectively. The method was applied to the determination of MMZ in spiked urine sample with excellent recoveries ranging from 90% to 95%, and the imprinted film was able to be reused for 20 times without loss of sensitivity. The results obtained by BELISA correlated well with that obtained by the high performance liquid chromatography (HPLC) method.

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Determination of thiocompounds by liquid chromatography with amperometric detection at a Nafion/indium hexacyanoferrate film modified electrode

Cited by 87 publications

References 26 publications

Voltammetric Determination of Methimazole Using a Carbon Paste Electrode Modified with a Schiff Base Complex of Cobalt

Voltammetric Determination of Methimazole Using a Carbon Paste Electrode Modified with a Schiff Base Complex of Cobalt

Electrocatalytic Oxidation of Hydrogen Peroxide and Cysteine at a Glassy Carbon Electrode Modified with Platinum Nanoparticle-deposited Carbon Nanotubes

Development of a Biomimetic Enzyme‐linked Immunosorbent Assay Method for the Determination of Methimazole in Urine Sample

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