Determination of thebaine in water samples, biological fluids, poppy capsule, and narcotic drugs, using electromembrane extraction followed by high-performance liquid chromatography analysis

Seidi, Shahram; Yamini, Yadollah; Heydari, Akbar; Moradi, Morteza; Esrafili, Ali; Rezazadeh, Maryam

doi:10.1016/j.aca.2011.05.042

Cited by 114 publications

(51 citation statements)

References 37 publications

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“…With 1-heptanol as the organic phase, 11 acidic drugs were extracted after 5 min of EME at 50 V. Both repeatability and linearity data were reported which supported the future potential of the procedure for analytical extractions. Very recently, the application of EME for extraction of amphetamines [93], β-blockers [94], thebaine [95], mebendazole [96] and levamisole [97] were reported. Other publications on EME system focused on the fundamentals of EME, and an equation was developed to describe the flux of analytes across the SLM in an EME system [98].…”

Section: Applications Of Three-phase Hf-lpmementioning

confidence: 99%

Developments in hollow fiber based liquid-phase microextraction: principles and applications

2012

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Section: Applications Of Three-phase Hf-lpmementioning

confidence: 99%

Developments in hollow fiber based liquid-phase microextraction: principles and applications

2012

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“…Applied voltage and extraction time are two correlative parameters and increasing of the extraction time limits the voltage and vice versa. For this reason, these two parameters were investigated simultaneously in recent works [20,21]. Herein, Extraction of the analytes was studied in different EME durations ranging from 5 to 20 min while the electrical potentials were applied in the range of 50-200 V. The results are summarized in Fig.…”

Section: Effect Of Applied Voltage and Extraction Timementioning

confidence: 99%

Electrical field-stimulated liquid-phase microextraction for trace analysis of pyridine and its derivatives in cigarette extract

et al. 2014

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“…Several methods were found in the literature including HPTLC (high-performance thin layer chromatography) [41], HPLC analysis [42][43][44][45][46] and GC determination [47][48][49][50].…”

Section: Introductionmentioning

confidence: 99%

Development of chromatographic methods for thebaine detection and quantification along with some of related alkaloid derivatives

Spasevska

Bogdanov

Babunovska³

2015

Maced. J. Chem. Chem. Eng.

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A RP-HPLC-UVD method for qualitative analysis and quantification of thebaine was developed utilizing RP-C18 monolithic column, gradient elution with trifluoroacetic acid and formic acid in water and in acetonitrile and detection wavelength of 285 nm. The effects of the relevant chromatographic conditions were investigated and the optimized and validated method was usеd for analysis of three in-house prepared batches of thebaine. Additionally, a complementary GC-MS method was developed for identification of thebaine and potential impurities. In parallel the batches were analyzed by routine methods for preliminary quality assessment based on physical and spectroscopic properties (melting point, specific optical rotation, UV-Vis and IR spectroscopy). There was correlation between the samples purity as determined by the developed HPLC method and the melting point ranges. The HPLC method herein presented is suitable for routine quantitative analysis regardless of the method of thebaine preparation and it is suitable for its corresponding free base or salt form. Additionally, considering the mobile phase compatibility, it can be adapted/transferred easily for HPLC-MS analysis, especially if the identity of the impurities needs to be determined.Keywords: thebaine; HPLC; purity; GC-MS; physical properties; spectroscopic properties; РАЗВОЈ НА ХРОМАТОГРАФСКИ МЕТОДИ ЗА ДЕТЕКЦИЈА И КВАНТИФИКАЦИЈА НА ТЕБАИН ЗАЕДНО СО НЕКОИ СРОДНИ АЛКАЛОИДНИ ДЕРИВАТИMетодатa RP-HPLC-UVD за квалитативна анализа и квантификација на тебаин е развиена со користење на монолитна колона RP-C18. Методата е со градиентна елуција со трифлуорооцетна и мравја киселина во вода и ацетонитрил и со детекција на 285 nm. Беа евалуирани ефектите на релевантните хроматографски услови и оптимизираната и валидирана метода беше применета за анализа на три подготвени серии тебаин. Дополнително беше развиена комплементарна GC-MS метода за идентификација на тебаин и потенцијалните нечистотии. Паралелно со хромато-графските методи, примероците на тебаин беа анализирани со рутински методи за прелиминарно одредување на квалитет, базирани на физички и спектроскопски својства (температура на топење, оптичка ротација, УВ-видлива и инфрацрвена спектроскопија). Постои корелација помеѓу чистотата на примероците одредена со HPLC и соодветните опсези на температурите на топење. Прикажаната HPLC метода е соодветна за рутинска анализа без разлика на методата на подготовка и може да се користи за тебаин како слободна база и за негови соли. Додатно, ако се земе предвид компатибилноста на мобилната фаза, развиената метода лесно може да се адаптира/трансферира за анализи со HPLC-MS, особено ако е потребно да се одреди идентитетот на нечистотиите.Клучни зборови: тебаин; HPLC; GC-MS; физички својства; спектроскопски својства; M. Spasevska, J. Bogdanov, H. Babunovska Maced. J. Chem. Chem. Eng. 34 (2), 231-243 (2015) 232

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Determination of thebaine in water samples, biological fluids, poppy capsule, and narcotic drugs, using electromembrane extraction followed by high-performance liquid chromatography analysis

Cited by 114 publications

References 37 publications

Developments in hollow fiber based liquid-phase microextraction: principles and applications

Developments in hollow fiber based liquid-phase microextraction: principles and applications

Electrical field-stimulated liquid-phase microextraction for trace analysis of pyridine and its derivatives in cigarette extract

Development of chromatographic methods for thebaine detection and quantification along with some of related alkaloid derivatives

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