Determination of the Thermal Noise Limit of Graphene Biotransistors

Crosser, Michael S.; Brown, M. C.; McEuen, Paul L.; Minot, Ethan D.

doi:10.1021/acs.nanolett.5b01788

Cited by 10 publications

(12 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After that, the data was grouped according to the electrode diameter, and the statistical SNR values were calculated separately for small (10 µm) and large (20 µm) electrodes. The noise values for the two electrode types, surprisingly do not vary too much (10.26 ± 4.8 µV for small and 10.7 ± 7.2 µV for large electrodes), which could be attributed to either the effect of quantum capacitance from the graphene, or to general noise restrictions due to thermal noise . As recently reported, the impedance of the graphene electrodes can be modeled via distribution of finite RC elements along the graphene‐electrolyte surface .…”

Section: Resultsmentioning

confidence: 53%

Graphene Multielectrode Arrays as a Versatile Tool for Extracellular Measurements

Kireev

Seyock

Lewen

et al. 2017

Adv Healthcare Materials

View full text Add to dashboard Cite

Graphene multielectrode arrays (GMEAs) presented in this work are used for cardio and neuronal extracellular recordings. The advantages of the graphene as a part of the multielectrode arrays are numerous: from a general flexibility and biocompatibility to the unique electronic properties of graphene. The devices used for extensive in vitro studies of a cardiac-like cell line and cortical neuronal networks show excellent ability to extracellularly detect action potentials with signal to noise ratios in the range of 45 ± 22 for HL-1 cells and 48 ± 26 for spontaneous bursting/spiking neuronal activity. Complex neuronal bursting activity patterns as well as a variety of characteristic shapes of HL-1 action potentials are recorded with the GMEAs. This paper illustrates that the potential applications of the GMEAs in biological and medical research are still numerous and diverse.

show abstract

Section: Resultsmentioning

confidence: 53%

Graphene Multielectrode Arrays as a Versatile Tool for Extracellular Measurements

Kireev

Seyock

Lewen

et al. 2017

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…S1 of the Supplemental Material 26 ), so the impact of charge transfer between the graphene and the ionic solution is negligible in liquidbased applications of back-gated GFET sensors [6]. However, in the liquid-gated GFET configuration, application of a gate voltage can cause the Faradaic current to be enhanced by orders of magnitude [22], to the point where it is comparable to the in-plane current [33].…”

mentioning

confidence: 99%

Quantifying the intrinsic surface charge density and charge-transfer resistance of the graphene-solution interface through bias-free low-level charge measurement

Ping

Johnson

2016

Applied Physics Letters

View full text Add to dashboard Cite

Liquid-based bio-applications of graphene require a quantitative understanding of the grapheneliquid interface, with the surface charge density of adsorbed ions, the interfacial charge transfer resistance, and the interfacial charge noise being of particular importance. We quantified these properties through measurements of the zero-bias Faradaic charge-transfer between graphene electrodes and aqueous solutions of varying ionic strength using a reproducible, low-noise, minimally perturbative charge measurement technique. The measurements indicated that adsorbed ions had a negative surface charge density of approximately -32.8 mC m -2 and that the specific charge transfer resistance was 6.5 ± 0.3 MΩ cm 2 . The normalized current noise power spectral density for all ionic concentrations tested collapsed onto a 1/f α characteristic with α=1.1±0.2. All the results are in excellent agreement with predictions of the theory for the

show abstract

“…Assuming a point-contact model [36] of coupling between the cell and the electrode, the depolarization of the cell membrane is coupled to the graphene electrode across a small gap, where the cell or tissue adheres to the surface. The potential change is then detected by the graphene electrodes via capacitive coupling [27,28,29].…”

Section: Resultsmentioning

confidence: 99%

Versatile Flexible Graphene Multielectrode Arrays

et al. 2016

View full text Add to dashboard Cite

Graphene is a promising material possessing features relevant to bioelectronics applications. Graphene microelectrodes (GMEAs), which are fabricated in a dense array on a flexible polyimide substrate, were investigated in this work for their performance via electrical impedance spectroscopy. Biocompatibility and suitability of the GMEAs for extracellular recordings were tested by measuring electrical activities from acute heart tissue and cardiac muscle cells. The recordings show encouraging signal-to-noise ratios of 65 ± 15 for heart tissue recordings and 20 ± 10 for HL-1 cells. Considering the low noise and excellent robustness of the devices, the sensor arrays are suitable for diverse and biologically relevant applications.

show abstract

Determination of the Thermal Noise Limit of Graphene Biotransistors

Cited by 10 publications

References 18 publications

Graphene Multielectrode Arrays as a Versatile Tool for Extracellular Measurements

Graphene Multielectrode Arrays as a Versatile Tool for Extracellular Measurements

Quantifying the intrinsic surface charge density and charge-transfer resistance of the graphene-solution interface through bias-free low-level charge measurement

Versatile Flexible Graphene Multielectrode Arrays

Contact Info

Product

Resources

About