Determination of the specific rate constants for the phagocytosis of radiogold colloids by the reticuloendothelial system in the rat

Hepatic ischemia reperfusion injury (IRI) is not only a pathophysiological process involving the liver, but also a complex systemic process affecting multiple tissues and organs. Hepatic IRI can seriously impair liver function, even producing irreversible damage, which causes a cascade of multiple organ dysfunction. Many factors, including anaerobic metabolism, mitochondrial damage, oxidative stress and secretion of ROS, intracellular Ca(2+) overload, cytokines and chemokines produced by KCs and neutrophils, and NO, are involved in the regulation of hepatic IRI processes. Matrix Metalloproteinases (MMPs) can be an important mediator of early leukocyte recruitment and target in acute and chronic liver injury associated to ischemia. MMPs and neutrophil gelatinase-associated lipocalin (NGAL) could be used as markers of I-R injury severity stages. This review explores the relationship between factors and inflammatory pathways that characterize hepatic IRI, MMPs and current pharmacological approaches to this disease.

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Determination of the specific rate constants for the phagocytosis of radiogold colloids by the reticuloendothelial system in the rat

Cited by 2 publications

References 8 publications

Evaluation of the reticuloendothelial system function by the vascular clearance of chondroitin sulfate iron colloid

Evaluation of the reticuloendothelial system function by the vascular clearance of chondroitin sulfate iron colloid

Hepatic ischemia reperfusion injury: A systematic review of literature and the role of current drugs and biomarkers

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