Determination of the Relative Permittivity of Acetylcholinesterase

Ramos, Angela S. F.; Techert, Simone

doi:10.1021/jz900261z

Cited by 2 publications

(2 citation statements)

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“…AChe is interesting in the context of the present review also because of experimental determination of the dielectric constant of AChE recently described by Ramos and Techert, 145 based on the interaction of an optically excited state of a fluorophore with surrounding solvent molecules. When the dipole moment of the fluorescent molecule is larger in the excited, relative to the ground, state, the degree of solvation of the excited state is highly dependent on the polarity of the solvent, and leads to an increase in the fluorescence of the Stokes shift with increasing solvent polarity.…”

Section: Acetylcholine Esterasementioning

confidence: 98%

Poisson–Boltzmann continuum-solvation models: applications to pH-dependent properties of biomolecules

Antosiewicz

Shugar

2011

Mol. BioSyst.

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All molecules can be viewed as either discrete or continuous assemblies of electric charges, and electrostatics plays a major role in intermolecular and intramolecular interactions. Moreover, charge distribution within molecules may fluctuate due to the presence of ionizable groups capable of exchanging protons with the environment, leading to pH-dependence of phenomena involving such molecules. Electrostatic aspects of complex shapes and environments of biological molecules, in vitro and in vivo, are relatively well amenable to treatment by Poisson-Boltzmann models, which are attractive in that they possess a clear physical meaning, and can be readily solved by several mathematically sound methods. Here we describe applications of these models to obtain valuable insights into some biologically important pH-dependent properties of biomolecules, such as stability, binding of ligands (including potential drugs), enzymatic activity, conformational transitions, membrane transport and viral entry.

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Section: Acetylcholine Esterasementioning

confidence: 98%

Poisson–Boltzmann continuum-solvation models: applications to pH-dependent properties of biomolecules

Antosiewicz

Shugar

2011

Mol. BioSyst.

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“….12)[90,[94][95][96][97][98][99][100][101][102][103], X-ray scattering on macromolecules (Fig.17.13) and (Fig. 17.14) [90, 115, 116, 118, 121] and X-ray spectroscopy (Fig.…”

mentioning

confidence: 99%

Development of Ultrafast X-ray Free Electron Laser Tools in (Bio)Chemical Research

Techert

Veedu

Bari

2020

Topics in Applied Physics

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The chapter will focus on fundamental aspects and methodological challenges of X-ray free electron laser research and recent developments in the related field of ultrafast X-ray science. Selected examples proving “molecular movie capabilities” of Free-electron laser radiation investigating gas phase chemistry, chemistry in liquids and transformations in the solid state will be introduced. They will be discussed in the context of ultrafast X-ray studies of complex biochemical research, and time-resolved X-ray characterisation of energy storage materials and energy bionics.

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Determination of the Relative Permittivity of Acetylcholinesterase

Cited by 2 publications

References 21 publications

Poisson–Boltzmann continuum-solvation models: applications to pH-dependent properties of biomolecules

Poisson–Boltzmann continuum-solvation models: applications to pH-dependent properties of biomolecules

Development of Ultrafast X-ray Free Electron Laser Tools in (Bio)Chemical Research

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