Determination of the Radiochemical Purity of Hippuran by HPLC

Pfeiffer, Gertrude; Beranek, I.

doi:10.1007/978-94-009-7669-6_4

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…But HPLC is the method of choice for the analytical quality control of some radioiodinated products. Our first product, regularily analysed by HPLC, was hippuran labelled with 123 I or 131 I, and we are now happy to be able to replace the very time-consuming paper chromatography, recommended by the European Pharmacopoea, by HPLC (11).…”

Section: Radiochemical Puritymentioning

confidence: 99%

Quality Control of Radiopharmaceuticals

Pfeiffer¹

1984

Nuklearmedizin

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SummaryA good quality assurance system ensures that a product will be safe and suitable for the intended use. Quality control is an important part of the quality assurance system. Two main topics are discussed in this paper:1. General aspects including regulations, possibilities, economics and responsibility; and2. Procedures: Methods for the determination of the physical, chemical, pharmaceutical and biological purity with special regard to new methods, problems and pitfalls, e.g.– the measurement of radioactivity using an isotope calibrator;– the radionuclidic purity of 123I;– alpha and beta-emitting impurities in 99mTc;– High-performance liquid chromatography (HPLC);– Mini-chromatograms; and– the value of animal tests.

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Section: Radiochemical Puritymentioning

confidence: 99%

Quality Control of Radiopharmaceuticals

Pfeiffer¹

1984

Nuklearmedizin

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“…The determination of the radiochemical purity of hippuran by HPLC was one of the first established HPLC-methods in routine quality control of the product. To begin with Boegl (5) RP-columns and aqueous methanol are generally used and there are only different opinions about the optimal concentra-tion and pH of the eluent (6,7). In our institution the system RP-S-10 and 30% methanol, pH 3.2, had been approved for routine quality control of I131_ and I 123 -labelled hippuran since many years (8).…”

Section: Introductionmentioning

confidence: 99%

Determination of the Radiochemical Purity of Hippuran by HPLC

Cited by 2 publications

References 2 publications

Quality Control of Radiopharmaceuticals

Quality Control of Radiopharmaceuticals

Quality Control of Radiopharmaceuticals: Recent Developments in Analytical Techniques

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