Determination of the pion-nucleon coupling constant

A Straightforward Synthesis of Emericellamide A Using Matteson’s Homologation Approach

“…This was the rationale we used to first connect the polyketide fragment 11 with Boc-alanine to obtain the ester 12 . 28 The optimal result was obtained with N , N ′-dicyclohexylcarbodiimide (DCC) and 4-pyrrolidinylpyridine 29 as esterification reagents; however, this approach resulted in an 81:19 diastereomeric mixture. Unfortunately, the diastereomers could not be separated at this stage.…”