Determination of the phosphorylated neurofilament subunit NF-H (pNF-H) in cerebro-spinal fluid as biomarker in acute traumatic spinal cord injuries / Dozarea neurofilamentelor fosforilate (subunitatea pNF-H) ȋn LCR ca biomarker ȋn traumatismul vertebro-medular acut

Ungureanu, Didona; Iencean, Stefan Mircea; Dimitriu, Cristina; Iencean, Andrei Stefan; Taşcu, A.

doi:10.2478/rrlm-2014-0029

Cited by 7 publications

(8 citation statements)

References 31 publications

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“…Ungureanu et al . () confirmed a substantial increase in CSF levels of heavy subunit of neurofilaments during the first 3 days between SCI patients and the control group. However, Hoska et al .…”

Section: Resultssupporting

confidence: 57%

“…In another study with a 12–18‐months follow up of patients, Ungureanu et al . () showed that this biomarker is able to predict the outcome of patients when measured in the first 6 h, but its levels do not show a significant difference when measured after 24 h.…”

Section: Resultsmentioning

confidence: 97%

“…Two studies assessed the diagnostic value of CSF level of heavy subunit of neurofilaments (Ungureanu et al . ) and nitric oxide (Hosaka et al . ) in detection of SCI.…”

Section: Resultsmentioning

confidence: 99%

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Potential diagnostic and prognostic value of serum and cerebrospinal fluid biomarkers in traumatic spinal cord injury: A systematic review

Yousefifard

Sarveazad

Babahajian

et al. 2019

Journal of Neurochemistry

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Section: Resultssupporting

confidence: 57%

Section: Resultsmentioning

confidence: 97%

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Potential diagnostic and prognostic value of serum and cerebrospinal fluid biomarkers in traumatic spinal cord injury: A systematic review

Yousefifard

Sarveazad

Babahajian

et al. 2019

Journal of Neurochemistry

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“…Recent studies suggested the utility of cerebrospinal fluid (CSF) neurofilaments for cerebrovascular and spinal pathology (2,3), but this type of sampling is more invasive and prone to severe side effects. As an important structural protein in neurons, increased concentration of neuro-filaments in peripheral blood might mirror the neuronal destruction in various central nervous system (CNS) disorders and to be considered a potential marker for axonal damage, detectable now in peripheral blood by sensitive ELISA methods (4), being at the same time a causative agent for neurological diseases and a marker for disease progression (5).…”

Section: Introductionmentioning

confidence: 99%

Plasma phosphorylated neurofilament heavy chains as a potential marker for ischemic stroke patients

Huţanu

Maier

Bălaşa

et al. 2018

Revista Romana De Medicina De Laborator

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Background:The aim of the study was to determine the utility of plasma NfH in correlation with serum hsCRP for severity and short-term functional outcome prediction after ischemic stroke.Methods: 124 patients and 40 healthy controls were enrolled, serial plasma neurofilament heavy chains and hsCRP concentrations were measured and evaluated for TOAST subtype, stroke severity and functional outcome at discharge.Results: Serum level of hsCRP was significantly higher in patients versus controls (p<0.05) with no difference between TOAST subtypes. Plasma NfH concentration on day 5 was higher in CE stroke compared to LAA group and SVO group. A positive correlation between NfH levels on day 5 and mRS at discharge (r=0.304, p=0.001) and a gender stratification of hsCRP and mRS at discharge was found. Values of 6.04 mg/l for hsCRP and 46.4 ng/ml for NfH were found predictive for unfavorable short-term outcome, but after adjusting for age, sex and stroke severity, the prediction power was lost.Conclusions: Plasma concentration of NfH shows a significant increase over the first five days after ischemic stroke, in correlation with inflammatory status and short-term evolution.

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“…Ungureanu et al . [ 17 ] did serial estimation of pNF-H in CSF of 15 patients with SCI (both cervical and dorsal) and concluded that it is an important predictor of severity of SCI and is sensitive to secondary lesions.…”

Section: Discussionmentioning

confidence: 99%

Phosphorylated neurofilament heavy: A potential blood biomarker to evaluate the severity of acute spinal cord injuries in adults

Singh

Kumar

Ali

et al. 2017

Int J Crit Illn Inj Sci

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Aims:The aim of this study is to analyze the serial estimation of phosphorylated neurofilament heavy (pNF-H) in blood plasma that would act as a potential biomarker for early prediction of the neurological severity of acute spinal cord injuries (SCI) in adults.Settings and Design:Pilot study/observational study.Subjects and Methods:A total of 40 patients (28 cases and 12 controls) of spine injury were included in this study. In the enrolled cases, plasma level of pNF-H was evaluated in blood samples and neurological evaluation was performed by the American Spinal Injury Association Injury Scale at specified period. Serial plasma neurofilament heavy values were then correlated with the neurological status of these patients during follow-up visits and were analyzed statistically.Statistical Analysis Used:Statistical analysis was performed using GraphPad InStat software (version 3.05 for Windows, San Diego, CA, USA). The correlation analysis between the clinical progression and pNF-H expression was done using Spearman's correlation.Results:The mean baseline level of pNF-H in cases was 6.40 ± 2.49 ng/ml, whereas in controls it was 0.54 ± 0.27 ng/ml. On analyzing the association between the two by Mann–Whitney U–test, the difference in levels was found to be statistically significant. The association between the neurological progression and pNF-H expression was determined using correlation analysis (Spearman's correlation). At 95% confidence interval, the correlation coefficient was found to be 0.64, and the correlation was statistically significant.Conclusions:Plasma pNF-H levels were elevated in accordance with the severity of SCI. Therefore, pNF-H may be considered as a potential biomarker to determine early the severity of SCI in adult patients.

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Determination of the phosphorylated neurofilament subunit NF-H (pNF-H) in cerebro-spinal fluid as biomarker in acute traumatic spinal cord injuries / Dozarea neurofilamentelor fosforilate (subunitatea pNF-H) ȋn LCR ca biomarker ȋn traumatismul vertebro-medular acut

Abstract: Study objective. The objective of this study was to measure the phosphorylated neurofilament subunit NF-H (pNF-H)

Cited by 7 publications

References 31 publications

Potential diagnostic and prognostic value of serum and cerebrospinal fluid biomarkers in traumatic spinal cord injury: A systematic review

Potential diagnostic and prognostic value of serum and cerebrospinal fluid biomarkers in traumatic spinal cord injury: A systematic review

Plasma phosphorylated neurofilament heavy chains as a potential marker for ischemic stroke patients

Phosphorylated neurofilament heavy: A potential blood biomarker to evaluate the severity of acute spinal cord injuries in adults

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