Determination of the optimal configuration of ALGRX 3268 for induction of local analgesia prior to venipuncture in the antecubital fossa

Apseloff, Glen; Singh, Alpana; Vause, E.; Richards, P.

doi:10.1016/j.jpain.2005.01.196

Cited by 4 publications

(2 citation statements)

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“…94 The significant analgesic effects of the LHM powder intradermal injection system have been demonstrated in pediatric populations undergoing venipuncture (Table 5). [95][96][97] In 1 randomized double-blind study, 307 children aged 3 to 18 years were randomly assigned to receive a predecessor system similar to the currently approved device or matching sham placebo at the back of the hand 2 to 3 minutes before venipuncture. 97 Subjects who received the active system exhibited mean pain reductions (effect sizes) of 33% to 46% relative to sham placebo.…”

Section: Laser-assisted Local Anesthetic Deliverymentioning

confidence: 99%

Pharmacologic Approaches for Reducing Venous Access Pain in Children

Zempsky

2008

Pediatrics

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A variety of pharmacologic options are available to clinicians who want to provide effective and safe topical local anesthesia to children undergoing venous access procedures. These options can be distinguished on the basis of how they deliver active drug through the impermeable outer layer of skin, the stratum corneum, to pain receptors located in the dermis and epidermis. Three general methodologies are typically used to bypass the stratum corneum: direct injection of local anesthetics, usually via a small-gauge hypodermic syringe; passive diffusion from topical creams or gels; and active needle-free drug strategies that enhance the rate of drug passage into the dermis and epidermis. Examples of the latter mechanisms include heatenhanced diffusion, iontophoresis, sonophoresis, laser-assisted transdermal passage, and pressurized gas delivery of powdered drug particles. Pharmacologic options in this setting can also be distinguished on the basis of the time to onset of full anesthetic effect. Several available agents induce significant local anesthesia within 1 to 3 minutes of administration, or faster, allowing easy integration into the skin preparation and subsequent venous access procedure. In combination with nonpharmacologic approaches, these agents can be used to dramatically lessen this significant source of pediatric pain. Pediatrics 2008;122:S140-S153

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Section: Laser-assisted Local Anesthetic Deliverymentioning

confidence: 99%

Pharmacologic Approaches for Reducing Venous Access Pain in Children

Zempsky

2008

Pediatrics

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“…Previous studies of similar delivery systems in adults and children showed onset of cutaneous analgesia within 1 to 3 minutes, reducing procedural pain. [17][18][19][20][21] In addition, an earlier randomized, doubleblind, placebo-controlled Phase III trial of this device in 579 children aged 3 to 18 years confirmed the 1-to 3-minute onset of action and a significant reduction in subsequent pain scores for venous cannulation or venipuncture in the back of the hand or the antecubital fossa. 22 The present, similarly designed study seeks to confirm the safety, efficacy, and tolerability of this delivery system.…”

Section: Introductionmentioning

confidence: 99%