Determination of the minimum infusion rate of propofol required to prevent purposeful movement of the extremities in response to a standardized noxious stimulus in goats

Ferreira, Jacques; Ndawana, Patience S.; Dzikiti, Loveness Nyaradzo; Dzikiti, Brighton T.

doi:10.1111/vaa.12327

Cited by 7 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The above dissimilarities on infusion rates may be the result of differences in the noxious stimulus used in above studies. In those reports [26,36], animals were subjected to supramaximal noxious stimulus, while in the current study animals were subjected to a surgical procedure and this stimulus may have exceeded the standardized supramaximal stimulus applied in research studies [20], the differences in noxious stimulation may have a great effect on the required infusion rate of anesthetic drugs [37]. Surgical stimulation may require higher anesthetic drug infusion rates in comparison with other methods used for imitating noxious stimulation [38].…”

Section: Discussionmentioning

confidence: 80%

Comparison of Propofol or Isoflurane Anesthesia Maintenance, Combined with a Fentanyl–Lidocaine–Ketamine Constant-Rate Infusion in Goats Undergoing Abomasotomy

Velázquez-Delgado

Gutiérrez‐Blanco

Torres-Acosta

et al. 2021

Animals

View full text Add to dashboard Cite

This study aimed to compare, first, the anesthetic and cardiopulmonary effects of propofol or isoflurane anesthetic maintenance in goats receiving a fentanyl–lidocaine–ketamine infusion undergoing abomasotomy and, secondly, to compare the quality of the recovery from anesthesia. Two groups were used: propofol (TIVA) and isoflurane (PIVA). Goats were premedicated with fentanyl (10 μg/kg intravenously [IV]), lidocaine (2 mg/kg, IV), and ketamine (1.5 mg/kg, IV). Anesthesia was induced with propofol and maintenance consisted of fentanyl (10 μg/kg/h, IV), lidocaine (50 μg/kg/min, IV), and ketamine (50 μg/kg/min, IV) as constant-rate infusions (CRIs), combined with either CRI of propofol at initial dose of 0.3 mg/kg/min, IV (TIVA), or isoflurane with initial end-tidal (FE’Iso) concentration of 1.2% partial intravenous anesthesia (PIVA). The mean effective propofol dose for maintenance was 0.44 ± 0.07 mg/kg/min, while the mean FE’Iso was 0.81 ± 0.2%. Higher systolic arterial pressure (SAP) values were observed in total intravenous anesthesia (TIVA) during some time points. Recovery was smooth in PIVA, while restlessness, vocalizations, and paddling were observed in TIVA. Both protocols produced a satisfactory quality of anesthesia during surgery, with minimal impact on cardiopulmonary function. Nevertheless, recovery after anesthesia in TIVA might be of poor quality.

show abstract