Determination of the Mechanical Properties of the Periodontal Ligament in a Uniaxial Tensional Experiment

Dorow, Christina; Krstin, N.; Sander, Franz Günter

doi:10.1007/s00056-003-0225-7

Cited by 82 publications

(68 citation statements)

References 14 publications

(61 reference statements)

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“…Moreover, periodontal tissue is continuously subjected to very dynamic forces, acting the periodontal ligament as a damper [27][28] . Therefore, the 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 27 viscoelastic properties displayed by the hydrogels herein developed are of paramount importance for periodontal therapy approaches.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Platelet Lysate-Loaded Photocrosslinkable Hyaluronic Acid Hydrogels for Periodontal Endogenous Regenerative Technology

Babo

Pires

Santos

et al. 2017

ACS Biomater. Sci. Eng.

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The integrity and function of the periodontium can be compromised by traumatic injuries or periodontitis. Currently available clinical therapies are able to stop the progression of periodontitis and allow the healing of periodontal tissue. However an optimal strategy capable of restoring the anatomy and functionality of the lost periodontal tissue is still to be achieved. This injectable system is based on a photocrosslinkable hydrogel, prepared from methacrylated Hyaluronic Acid (me-HA) and incorporating Platelet Lysate (PL). The delivery of growth factors and cells in situ is expected to enhance regeneration of the periodontium. Various formulations of me-HA containing increasing PL concentrations were studied for achieving the formation of stable photocrosslinkable hydrogels. The produced hydrogels were subsequently characterized to assess mechanical properties, degradation, protein/growth factor release profile, antimicrobial activity and response towards human Periodontal Ligament fibroblasts (hPDLFs). The results demonstrated that it was possible to obtain stable photocrosslinkable hydrogels incorporating different amounts of PL that can be released in a sustained manner. Furthermore, the incorporation of PL improved (p<0.02) the viscoelastic properties of the hydrogels and enhanced their resilience to the degradation by hyaluronidase (HAase). Additionally, the PL showed to provide antimicrobial properties.Finally, hPDLFs, either seeded or encapsulated into the developed hydrogels, showed enhanced proliferation over time (p<0.05), proportionally to the increasing amounts of PL present in the hydrogel formulations.

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Section: Antimicrobial Activitymentioning

confidence: 99%

Platelet Lysate-Loaded Photocrosslinkable Hyaluronic Acid Hydrogels for Periodontal Endogenous Regenerative Technology

Babo

Pires

Santos

et al. 2017

ACS Biomater. Sci. Eng.

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“…The modulus of elasticity (E) and Poisson's ratio (µ) of each tissue were referred from previous studies 7,[12][13][14][15][16] and are shown in Table 1. Nine combination groups of different bilinear elastic moduli of the PDL for each phase (E1 and E2) were assumed for comparison (M1-M9, Table 2).…”

Section: Materials Propertiesmentioning

confidence: 99%

“…Nine combination groups of different bilinear elastic moduli of the PDL for each phase (E1 and E2) were assumed for comparison (M1-M9, Table 2). Values of E1 and E2 which were to be investigated were proposed on the basis of earlier papers 7,8,12,13) . In these papers E1 and E2 ranged from 0.05 MPa to 0.…”

Section: Materials Propertiesmentioning

confidence: 99%

“…Table 1 The modulus of elasticity (E) and Poisson's ratio (µ) of the tooth structures and the bone. Data were referred from previous studies 7,[10][11][12][13][14] . Table 2 Nine combination groups of different elastic moduli of the PDL for the first and second phases (E1 and E2) with strain ranges below and over ε12=0.075, respectively.…”

Section: Materials Propertiesmentioning

confidence: 99%

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Bilinear elastic property of the periodontal ligament for simulation using a finite element mandible model

et al. 2011

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This study aimed to introduce a procedure for determining the bilinear elastic moduli (E1 and E2) of the periodontal ligament for a mathematical tooth model to analyse stress in the mandible. The bone and tooth morphology were scanned from a dry skull and an extracted intact tooth, respectively, and reconstructed in a three-dimensional finite element model. The model showed good agreement with previously reported in vivo premolar movement when an E1 for the first phase tooth movement of 0.05 MPa and an E2 for the second phase of 8.0 MPa with ε12 of 0.075 were adopted. The mandible model analysis indicated that a remarkably high maximum compressive stress in the cervical cortical bone and the tensile stress in areas of masticatory muscle attachment were found. Future stress analyses using a jaw model may follow the process of determination of bilinear moduli to enhance accurate simulation with less calculation time.

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“…Pini et al reported the mechanical response of the PDL, which was obtained from different portions of bovine incisors and molars when they were subjected to uniaxial tension and compression (Pini et al, 2004). In other research, a laser-optical system was designed to verify the behavior of porcine teeth and the existence of hysteresis under different strain rates was reported (Dorow et al, 2002(Dorow et al, , 2003Natali et al, 2007). Although the sliced samples were taken from part of a tooth, the results of these studies reflect the typically non-linear behavior of the partial PDL, but may not be representative for the entire PDL.…”

Section: Introductionmentioning

confidence: 99%

Holistic force-displacement behavior of porcine periodontal ligament—numerical simulation and in-vitro experiment

Yao-Ning

Chen

et al. 2017

JBSE

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In recent years, orthodontic treatments have become increasingly popular. In these treatments, orthodontic forces, which cause the absorption and deposition of alveolar bone, are applied through brackets and teeth in order to move the teeth to the expected position. The periodontal ligament (PDL) has a determinative role in dental biomechanics; however, the difficulty of predicting PDL behavior has limited the advancement of dental biomechanics. Therefore, this study intends to measure the biomechanical behavior of the PDL and then develop an analytical model to predict the holistic force-displacement relationship of the tooth. In this study, a porcine premolar, including the tooth, periodontal ligament, and alveolar bone, was harvested for experimental purposes. A custom-made apparatus was designed to measure the force-displacement relationship of the PDL. Three analytical models, including linear, exponential, and power functions, were adapted to fit the experimental results. In addition, three-dimensional finite element models were constructed from micro-CT sectional images, and the hyperelastic behavior (Mooney-Rilvin equation) of the PDL was simulated. The results showed that the PDL exhibited nonlinear biomechanical behavior. The power function was found to be a good fit for the force-displacement relationship of the PDL. Furthermore, it was found that the hyperelastic model could predict the biomechanical behavior of the PDL for tension less and equal to 20 N.

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Determination of the Mechanical Properties of the Periodontal Ligament in a Uniaxial Tensional Experiment

Abstract: Knowledge of the material properties of the periodontal ligament is fundamental to an understanding of orthodontic tooth movement and thus to selection of an optimal force system for orthodontic treatment.

Cited by 82 publications

References 14 publications

Platelet Lysate-Loaded Photocrosslinkable Hyaluronic Acid Hydrogels for Periodontal Endogenous Regenerative Technology

Platelet Lysate-Loaded Photocrosslinkable Hyaluronic Acid Hydrogels for Periodontal Endogenous Regenerative Technology

Bilinear elastic property of the periodontal ligament for simulation using a finite element mandible model

Holistic force-displacement behavior of porcine periodontal ligament—numerical simulation and in-vitro experiment

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