Determination of the limit of quantification of the calorimeter using a mixture of benzoic acid and silicon dioxide

Abstract

In recent years quality control has received a great attention in laboratory work. Implementation of the international standard ISO/IEC 17025 is necessary for any laboratory that wishes to establish quality control in its work. One of the important factors for meeting the requirements of this standard is the usage of the certified reference materials (CRM) in laboratory work. In order to determine the performance of the calorimeter, benzoic acid as CRM, from AlliedSignal Riedelda Haen, Ref.: 33045 and SiO2, Pro analyze, in various mass ratios was used. The results showed that benzoic acid can be successfully utilized for the control of the entire technical and instrumental measuring range and resolve the problem of determination of the limit of detection and quantification of the calorimeter

Verification and validation of analytical methods in accordance with the ISO/IEC 17025 standard

“…Predstavlja najnižu koncentraciju/količinu analita koja se odgovarajućom metodom može detektovati sa određenim nivoom pouzdanosti, ali ne i da bude kvantifikovana. U procesu validacijie ovaj pojam se naziva limitom detekcije, LoD [3,6,[10][11].…”

“…(13) gde je: s b -standardna devijacija "slepog" reagensa ili "slepog" uzorka [4,9,11] Koristeći kriterijum detekcije, CD, najniža vrednost koja se odgovarajućim intervalom poverenja razlikuje od nule, može se izračunati LoD, po obrascu [10]:…”