Determination of the incidence of sensitization after penicillin skin testing

Nugent, Jeffrey S.; Quinn, James A.; McGrath, Christianne M.; Hrncir, David; Boleman, William T.; Freeman, Theodore M.

doi:10.1016/s1081-1206(10)61823-6

Cited by 32 publications

(19 citation statements)

References 16 publications

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“…Penicillin skin testing might sensitize a very small proportion of patients. 232 Penicillin and cephalosporins share a common beta lactam ring, but the extent of allergic cross-reactivity between the two families appears to be relatively low. Some studies have demonstrated no serious allergic reactions in large groups of patients with a history of penicillin allergy who were treated with cephalosporins.…”

Section: Beta Lactam Antibioticsmentioning

confidence: 99%

The diagnosis and management of anaphylaxis practice parameter: 2010 Update

Lieberman

Nicklas

Oppenheimer

et al. 2010

Journal of Allergy and Clinical Immunology

664

818

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These parameters were developed by the Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma & Immunology (AAAAI); the American College of Allergy, Asthma & Immunology (ACAAI); and the Joint Council of Allergy, Asthma and Immunology. The AAAAI and the ACAAI have jointly accepted responsibility for establishing "The Diagnosis and Management of Anaphylaxis Practice Parameter: 2010 Update." This is a complete and comprehensive document at the current time. The medical environment is a changing environment, and not all recommendations will be appropriate for all patients. Because this document incorporated the efforts of many participants, no single individual, including those who served on the Joint Task Force, is authorized to provide an official AAAAI or ACAAI interpretation of these practice parameters. Any request for information about or an interpretation of these practice parameters by the AAAAI or ACAAI should be directed to the Executive Offices of the AAAAI, the ACAAI, or the Joint Council of Allergy, Asthma and Immunology. These parameters are not designed for use by pharmaceutical companies in drug promotion.

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Section: Beta Lactam Antibioticsmentioning

confidence: 99%

The diagnosis and management of anaphylaxis practice parameter: 2010 Update

Lieberman

Nicklas

Oppenheimer

et al. 2010

Journal of Allergy and Clinical Immunology

664

818

View full text Add to dashboard Cite

show abstract

“…13 In addition, sensitization after skin testing occurs, and the rarely reported serious reactions are also to be considered. 14,15 No single test is satisfactory for the clinical evaluation of cephalosporin-allergic patients. In patient 4, we also checked the serum specific IgE levels to other cephalosporins, including cefadroxil, cephalexin, ceftriaxone, and ampicillin, but specific IgE antibodies were not detected to these antibiotic-HSA conjugates using our ELISA system.…”

Section: Discussionmentioning

confidence: 99%

Heterogeneity of the IgE response to allergenic determinants of cefaclor in serum samples from patients with cefaclor-induced anaphylaxis

Kim¹,

Choi²,

Park³

2005

Annals of Allergy, Asthma & Immunology

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“…In one study, where repeated courses of penicillins were given to subjects suspected of being allergic to BL, the figures were very low. In another study where skin testing was done with no interference from simultaneous drug administration, a 2.5% rate of resensitization appeared after repeated skin testing [26] .…”

Section: Drug Provocation Testsmentioning

confidence: 94%

Urticaria and Anaphylaxis due to Betalactams (Penicillins and Cephalosporins)

Torres¹,

Mayorga²,

Blanca³

2007

Drug Hypersensitivity

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Anaphylaxis and urticaria are the main clinical entities associated with betalactam allergy. They usually occur within 1 h of drug exposure, although urticaria may occasionally appear later. The shorter the interval to the reaction, the greater the possibility of this being IgE mediated, although in some cases of late-onset urticaria a T-cell mechanism has to be considered. Initially the haptens identified were benzylpenicilloyl and minor determinant mixtures of benzylpenicillin. Because of the changing patterns of consumption over the years, other betalactams, such as amoxycillin and cephalosporins, are now the most common drugs inducing reactions with the involvement of side-chainspecific determinants. These points, among others, are essential for performing in vivo and in vitro tests and understanding cross-reactivity.

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Determination of the incidence of sensitization after penicillin skin testing

Cited by 32 publications

References 16 publications

The diagnosis and management of anaphylaxis practice parameter: 2010 Update

The diagnosis and management of anaphylaxis practice parameter: 2010 Update

Heterogeneity of the IgE response to allergenic determinants of cefaclor in serum samples from patients with cefaclor-induced anaphylaxis

Urticaria and Anaphylaxis due to Betalactams (Penicillins and Cephalosporins)

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