Determination of the histological distribution of insulin like growth factor 1 receptors in the rat gut.

Abstract

The histological distribution of insulin like growth factor 1 (IGF 1) receptors in the rat gut was studied.

Pre-treatment with insulin-like growth factor-I partially ameliorates 5-fluorouracil-induced intestinal mucositis in rats

“…Efficacy, however, has not been restricted to individual growth factors, and has been reported following oral administration of an extract of growth factors derived from bovine cheese whey [29]. Since receptors for IGF-I are strongly expressed in the intestinal crypts, [31] and exogenously-administered IGF-I has resulted in potent intestino-trophic responses [15,20,21], and mucosal repair [22,25] we investigated the capacity for IGF-I to protect the intestine from damage utilizing a model of chemotherapy-induced intestinal mucositis.…”

Insulin‐like Growth Factor‐I Prevents Gut Atrophy and Maintains Intestinal Integrity in Septic Rats

“…The direct action on gut could be supported by the detection of IGF-I and IGF-II receptors covering all of the segments of the gut. 9,27,29 Although in recent years a number of observations led to the theory that the primary actions of IGF-I occured via paracrine or autocrine mechanisms close to the site of its production, IGF-I does have endocrine actions in the circulation.3° This is important because the exogenous e administration of IGF-I in this study depends primarily g on such endocrine actions. Various studies showed I consistently that systemically administered IGF-I can t promote growth, and they demonstrated that IGF-I can 1 leave the circulation and reach important target tissue.31 « In this experiment, the higher total and free plasma « IGF-I concentrations in the IGF group, especially the I latter, may make more IGF-I available to the intestine.…”

The Role of Nitric Oxide in the Effects of Ovarian Steroids in the Duodenum

“…And these immunoreactions were significantly greater in the surface epithelium and crypts in the P group and it decreased in the crypts in E2 group compared to the Ov group. Crypts represent regions of rapid mitosis and differentiation, providing a continual turnover of cells that differentiate into columnar and goblet cells as they migrate from the crypts towards the luminal end of the villi [36,37] . Previous studies also revealed the presence of iNOS immunoreactivity in myenteric neurons, in smooth muscle cells, and in endothelium of the rat duodenum with postembedding immunoelectronmicroscopy [26] .…”