Determination of the dynamic metastable limit for α-lactose monohydrate crystallization

Wong, Shin Yee; Bund, Rajesh K.; Connelly, Robin K.; Hartel, Richard W.

doi:10.1016/j.idairyj.2011.05.003

Cited by 27 publications

(44 citation statements)

References 9 publications

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“…Such a crystallisation gap was first described by Mullin 29 , and has also been noted by Flood and Wantha 30 and by Heffels, de Jong and 20 Sinke 31 and discussed by the present authors 32 but one of the problems which this engenders deserves elaborating. If there is such a zone, showing an hysteresis, how is it possible to derive an exact thermodynamic solubility value, since an hysteresis and a thermodynamic equilibrium are incompatible for the 25 same event? The explanation is probably that any collection of crystals will display a range of stabilities.…”

Section: The Dead Zonementioning

confidence: 99%

“…This is partly due to a lack of consensus on nomenclature describing the concept, but generally down to a lack of recognition or awareness of it. This perspective article aims, for 25 the first time and often drawing on examples hidden unrecognised in the literature, to provide a standard set of terms and fully characterise this phenomenon.…”

Section: Introductionmentioning

confidence: 99%

“…The terms 'surface secondary nucleation', 'activated 15 secondary nucleation' and 'surface-activated secondary nucleation' have been used by Puel, Veesler and co-workers [19][20][21] to describe what appears to be the onset of the same boundary. Agrawal 23 and 'nuclei first detection curve' 25 . It seems probable that these all represent the same thing, but measured 25 under different conditions.…”

Section: Introductionmentioning

confidence: 99%

“…Agrawal 23 and 'nuclei first detection curve' 25 . It seems probable that these all represent the same thing, but measured 25 under different conditions. It will be noted that there may be at least two phenomena being discussed under one umbrella here: failure of added seeds to proliferate and failure of spontaneously generated seeds to proliferate until the supersaturation increases beyond a certain point.…”

Section: Introductionmentioning

confidence: 99%

“…It is not even certain that the primary product crystals are responsible for the subsequent nucleation, and therefore whether it can 35 properly be described as secondary nucleation according to the accepted definition of the term. In describing the division as the 'dynamic metastable limit', further confusion about the nature of the boundary appears to have been generated 25 . It is important to realise that the secondary nucleation threshold 40 marking the limit of this area is not the 'dynamic metastable limit'.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

A perspective on the growth-only zone, the secondary nucleation threshold and crystal size distribution in solution crystallisation

Threlfall

Coles

2016

CrystEngComm

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The metastable zone between the solubility curve and the crystallisation curve can be divided into two regions, separated by the secondary nucleation threshold. At a supersaturation less than that of the secondary nucleation threshold seeds will grow but not proliferate. At greater supersaturations, they will proliferate. Although this concept has been known in connection with the commercial crystallisation of sucrose and of lactose for almost a century it is virtually unrecognised beyond the sugar and dairy 10 industries. The consequences are explored of the existence of such a boundary on the crystallisation process and the influence on crystal size distribution. It is recognised that the secondary nucleation threshold is the 'seeded metastable limit', but there are important consequences of avoiding the latter term. Mullin's 'Latent Period' is shown to be closely related to the 'growth only' zone within the metastable zone.15

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Section: The Dead Zonementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A perspective on the growth-only zone, the secondary nucleation threshold and crystal size distribution in solution crystallisation

Threlfall

Coles

2016

CrystEngComm

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Milk Specifics

Boer¹

2014

From Milk By‐Products to Milk Ingredients

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The Effect of Power, Pulse Rate and Treatment Time of Sonication on the Nucleation and Growth of α‐Lactose Monohydrate (α‐LM) Single Crystals from Aqueous Solution

Vinodhini

Srinivasan

2018

Crystal Research and Technology

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In the present study, different kinds of ultrasound variables such as power (P‐75W to 225W), pulse rate (Pr‐10s to 60s) and treatment time (T‐04 min and T‐08 min) are employed on the crystallization of α‐ lactose monohydrate (α‐LM) from aqueous solution. The applied energy density of sonication in aqueous solution shows a profound effect on the nucleation and growth characteristics of α‐LM as regards the principal benefits such as reduction of induction period and supersaturation levels required for nucleation, decrease in crystal size with narrow crystal size distribution (CSD) and increase in nucleation rate than uninsonated solution, but have no effect on crystal morphology. Ultrasound promotes only α‐LM nucleation and no nucleation of either both α and β‐L is observed in all the 36 experiments carried out. The form of grown crystals is confirmed by powder X‐ray diffraction (PXRD) and their thermal behaviour is studied by differential scanning calorimetry (DSC) analyses. The purity of the grown crystals is determined using automatic digital polarimeter.

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Determination of the dynamic metastable limit for α-lactose monohydrate crystallization

Cited by 27 publications

References 9 publications

A perspective on the growth-only zone, the secondary nucleation threshold and crystal size distribution in solution crystallisation

A perspective on the growth-only zone, the secondary nucleation threshold and crystal size distribution in solution crystallisation

Milk Specifics

The Effect of Power, Pulse Rate and Treatment Time of Sonication on the Nucleation and Growth of α‐Lactose Monohydrate (α‐LM) Single Crystals from Aqueous Solution

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