Determination of the Decomposition of Aspirin

Kelly, Clark A.

doi:10.1002/jps.2600590802

Cited by 67 publications

(18 citation statements)

References 49 publications

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“…The rate of hydrolysis of ASA in aqueous solutions is quite constant from pH 5 to 9 (10). Under more alkaline conditions, however, the rate of hydrolysis increases markedly (10). Thus the leveling off noted in Fig.…”

Section: Methodsmentioning

confidence: 75%

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The acetylation of hemoglobin by aspirin. In vitro and in vivo.

Bridges¹,

Schmidt²,

Jensen³

et al. 1975

J. Clin. Invest.

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Section: Methodsmentioning

confidence: 75%

“…As the drug circulates in the plasma it is readily hydrolyzed to salicylic acid and acetate ion. This reaction proceeds very slowly at neutral pH in the absence of enzyme (10). Hydrolysis is enhanced during passage through the liver and other organs (17).…”

Section: Methodsmentioning

confidence: 99%

The acetylation of hemoglobin by aspirin. In vitro and in vivo.

Bridges¹,

Schmidt²,

Jensen³

et al. 1975

J. Clin. Invest.

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“…ASA is absorbed intact in the gastrointestinal tract. As the drug circulates in the plasma, it is readily hydrolyzed to salicylic acid and acetate ion (Kelly, 1970). After oral administration of aspirin in human, only 68% of the ingested dose reaches the systemic circulation as aspirin, where it is converted into salicylate, spontaneously or by nonspecific esterases.…”

mentioning

confidence: 99%

Investigation of the Mechanisms Involved in the High-Dose and Long-Term Acetyl Salicylic Acid Therapy of Type I Diabetic Rats

Jafarnejad¹,

Bathaie²,

Nakhjavani³

et al. 2007

J Pharmacol Exp Ther

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Diabetes mellitus has been classified as a conformational disease because of changes induced in the structure and function of proteins due to hyperglycemia. In this study, we investigated the effect of high-dose and long-term use of acetyl salicylic acid (ASA) on the streptozotocin-induced diabetic rats as a model of type I diabetes, with consideration on the structure and/or function of proteins. The N-[methylnitrosocarbamoyl]-D-glucosamine (streptozotocin)-induced diabetic rats together with the normal rats were studied for 5 months with and without receiving 100 mg/kg ASA in drinking water. All rats were investigated from different aspects such as heat shock protein (HSP) 70 level, serum glucose and insulin concentration, advanced glycated end product (AGE) and glycated hemoglobin (HbA1c) formation, lipid profile, high-density lipoprotein (HDL) functionality (paraoxonase1 and lecithin cholesterol acyltransferase activities), and the antioxidant system. In addition, the in vitro effect of ASA on the structure of albumin as a model protein was studied in the presence of glucose by spectroscopic techniques such as fluorometry and circular dichroism. The results show that ASA therapy causes a decrease in the glucose level and AGE and HbA1c formation, improves the lipid profile, HDL functionality, and the antioxidant capacity, induces serum HSP70, and overall decreases mortality of diabetic rats in comparison with the group without treatment. The conformation of glycated bovine serum albumin is different from the native form, and ASA retains the conformation of this protein similar to the native. The improving effect of ASA on diabetic rats is mostly due to its role as a chemopreventive agent in the structural conservation and protection of proteins involved in diabetes pathogenesis.

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“…18 ' 19 As described in Figure 2 and Table 2, salicylic acid affected platelet deformability like ASA but the effect was not as pronounced. Salicylic acid significantly altered all of the deformability parameters in the same manner as ASA, but the magnitude of the influence of salicylic acid on platelet deformability was less than the effect of ASA (p<0.05).…”

Section: Resultsmentioning

confidence: 87%

Aspirin treatment reduces platelet resistance to deformation.

Burris¹,

Smith²,

Rao³

et al. 1987

Arteriosclerosis

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The present investigation has evaluated the influence of aspirin, Its constituents, and other nonsteroldal anti-Inflammatory agents on the resistance of human platelets to aspiration into mlcropipettes. Aspirin Increased the length of platelet extensions Into the micropipette over the entire negative tension range of 0.04 to 0.40 dynes/cm after exposure to the drug in vitro or after ingestlon of the agent. Other cyclooxygenase inhibitors, Ibuprofen and Indomethacln, did not increase platelet doformablllty. The Influence of aspirin was mimicked to some degree by high concentrations of salicylic acid, but acetylation of platelets with acetic anhydride had little influence on platelet deformablllty. Incubation of platelets with both salicylic acid and acetic anhydride had no more effect than salicylic acid alone. Benzole acid, chemically similar to salicylic acid, had a minimal effect. The studies demonstrate that aspirin makes platelets more deformable, while components of the drug or other nonsteroidal antiInflammatory agents and cyclooxygenase Inhibitors do not have the same influence on resistance to deformation. (Arteriosclerosis 7:385-388, July/August 1987) R ecent studies in our laboratory have used the technique of micropipette elastimetry to evaluate the resistance of platelets to deformation.12 Investigations into the effects of chilling and of antimitotic agents demonstrated that intact microtubule coils are critical for platelet resistance to aspiration into micropipettes.12 Exposure of platelets to cytochalasin B before aspiration showed that actin microfilament assembly was also important in platelet stability.

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Determination of the Decomposition of Aspirin

Cited by 67 publications

References 49 publications

The acetylation of hemoglobin by aspirin. In vitro and in vivo.

The acetylation of hemoglobin by aspirin. In vitro and in vivo.

Investigation of the Mechanisms Involved in the High-Dose and Long-Term Acetyl Salicylic Acid Therapy of Type I Diabetic Rats

Aspirin treatment reduces platelet resistance to deformation.

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