We reconsider our former determination of the chiral quark condensate qq from the related QCD spectral density of the Euclidean Dirac operator, using our Renormalization Group Optimized Perturbation (RGOPT) approach. Thanks to the recently available complete five-loop QCD RG coefficients, and some other related four-loop results, we can extend our calculations exactly to N 4 LO (five-loops) RGOPT, and partially to N 5 LO (six-loops), the latter within a well-defined approximation accounting for all six-loop contents exactly predictable from five-loops RG properties. The RGOPT results overall show a very good stability and convergence, giving primarily the RG invariant (RGI) condensate, qq 1/3 RGI (n f = 0) = −(0.840 +0.020 −0.016 )Λ0, qq 1/3 RGI (n f = 2) = −(0.781 +0.019 −0.009 )Λ2, qq 1/3 RGI (n f = 3) = −(0.751 +0.019−.010 )Λ3, whereΛn f is the basic QCD scale in the M S-scheme for n f quark flavors, and the range spanned is our rather conservative estimated theoretical error. This leads e.g. to qq 1/3 n f =3 (2 GeV) = −(273 +7 −4 ± 13) MeV, using the latestΛ3 values giving the second uncertainties. We compare our results with some other recent determinations. As a by-product of our analysis we also provide complete five-loop and partial six-loop expressions of the perturbative QCD spectral density, that may be useful for other purposes.