Determination of the antibacterial activity of crude extracts and compounds isolated from Hortia oreadica (Rutaceae) against oral pathogens

Severino, Vanessa Gisele Pasqualotto; Silva, Maria Fátima das Graças Fernandes da; Lucarini, Rodrigo; Montanari, L; Cunha, Wilson Roberto; Vinholis, Adriana Helena Chicharo; Martins, Carlos Henrique Gomes

doi:10.1590/s1517-83822009000300015

Cited by 12 publications

(8 citation statements)

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“…Considering the phytochemicals, the major components identified in H. brasiliana were the alkaloids and these are described as chemical markers of the species (Suárez et al, 1998;Shin et al, 2007;Lee et al, 2008;Severino et al, 2009a;Liao et al, 2011). However, based on the polarity of the compounds extracted in the hexane extract, sesquiterpenes, diterpenes, hydrocarbons and pentacyclic triterpenes were detected in the hexane extract from H. brasiliana leaves and these chemical classes may be responsible for the pharmacological activities reported in the present study.…”

Section: Discussionmentioning

confidence: 57%

“…Considering the phytochemical and pharmacological aspects, H. brasiliana has been described as a large source of alkaloids, coumarins, flavonoids, and limonoids (Suárez et al, 1998;Severino et al, 2009aSeverino et al, , 2009bSeverino et al, , 2012. Five alkaloids were isolated from wood and identified as flindersine, N-methylflindersine, γ-fagarine, skimmianine and 2,4-dimethoxyquinoline (Suárez et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…A tetranortriterpenoid and two dihydrocinnamic acid derivatives, as well as alloxanthoxyletin, nerolidol, epoxynerolidol, three known dihydrocinnamic acid derivatives and two amides were obtained from the wood (Suárez et al, 2002). Four dihydrocinnamic acid derivatives, limonoid guyanin and furoquinoline alkaloid dictamnine, obtained from roots, showed antibacterial activity (Severino et al, 2009a). Rutaecarpine, found in leaves and wood of H. brasiliana, has demonstrated different pharmacological properties, including analgesic and anti-inflammatory (Shin et al, 2007;Lee et al, 2008;Liao et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Antinociceptive and anti-inflammatory activities of the hexane extract from Hortia brasiliana Vand. leaves on experimental animal models

Magalhatilde;es¹

2013

Afr. J. Pharm. Pharmacol.

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Antinociceptive and anti-inflammatory activities of the hexane extract from Hortia brasiliana Vand. leaves were investigated by experimental animal models. Guaiol (9.72%), nonacosane (25.57%) and eicosane (10.80%) were the most abundant components identified by GC/MS. The extract, with LD 50 of 2.40 g/kg, reduced the number of abdominal contortions by 13.86 (100 mg/kg) and 18.51% (200 mg/kg). Doses of 100 and 200 mg/kg inhibited both phases of the time paw licking: First phase (9.44% and 16.32%) and the second phase (11.97 and 23.49%), respectively. The extract increased the reaction time on a hot plate at doses of 100 (24.92%) and 200 mg/kg (55.69%) after 90 min of treatment. The paw edema was reduced by the hexane extract at doses of 100 (10.42 and 8.23%) and 200 mg/kg (15.62 and 17.65%) after 3 to 4 h of application of carrageenan, respectively. At the dose of 200 mg/kg, the extract reduced the exudate volume by 19.44%, while the leucocyte migration was inhibited at the doses of 100 and 200 mg/kg (6.13 and 13.84%, respectively). These results suggest that H. brasiliana can be an active source of substances with antinociceptive and anti-inflammatory activities supporting the use in the Brazilian folk medicine.

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Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antinociceptive and anti-inflammatory activities of the hexane extract from Hortia brasiliana Vand. leaves on experimental animal models

Magalhatilde;es¹

2013

Afr. J. Pharm. Pharmacol.

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“…Severino et al (2009) verified antimicrobial activity of the hexane extract of H. oreadica roots and the dictamnine alkaloid isolated of this extract against oral pathogens Enterococcus faecalis (ATCC 4082), Streptococcus salivarius (ATCC 25975), S. mitis (ATCC 49456), S. mutans (ATCC 25275), S. sobrinus (ATCC 33478), S. sanguinis (ATCC 10556) and Lactobacillus casei (ATCC 11578). Severino et al (2015) demonstrated an inhibitory effect of the dichloromethane extract of leaves of H. oreadica (MIC 31.25 g/ml), indolequinazoline (15.62 g/ml) and furoquinoline (31.25 g/ml) alkaloids, and dihydrocinnamic acid derivatives (62.50 g/ml) on the growth of M. tuberculosis.…”

Section: Introductionmentioning

confidence: 66%

Chemical composition of essential oils of leaves, flowers and fruits of Hortia oreadica

Santos

Ferreira

Borges

et al. 2016

Revista Brasileira de Farmacognosia

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BJP 183 1-6 Revista Brasileira de Farmacognosia xxx (2015) xxx-xxx w w w . s b f g n o s i a . o r g . b r / r e v i s t a a b s t r a c t Hortia oreadica Groppo, Kallunki & Pirani, Rutaceae, known as "para-tudo", "quina", and "quina-docampo", is used in traditional medicine locally to treat stomach pain and fevers. The aims of this study were: analyze the chemical composition of essential oils from leaves, flowers and fruits of H. oreadica and verify the seasonal variation of the chemical components of essential oils from leaves. The essential oils were obtained by hydrodistillation using a Clevenger type apparatus and analyzed by GC/MS. The major components found in the samples of the essential oils were the amorpha-4,7(11)-diene (29.27% -flowers, 20.26% -fruits, 27.66-37.89% -leaves), bicyclogermacrene (23.28% -flowers, 20.64% -fruits, 14.71% to 31.37% -leaves). This work represents the first study of the chemical composition of essential oils from leaves, flowers and fruits and seasonal variation in the essential oils from leaves of H. oreadica.

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“…Valores entre 0,6-1,5 mg/mL denotam extratos moderadamente ativos, enquanto valores acima de 1,6 mg/mL são associados a extratos pouco ativos (Aligiannis et al, 2001;Severino et al, 2009 261,06 µg/mL).…”

Section: Atividade Antimicrobianaunclassified

Atividades biológicas dos alcaloides de Annona crassiflora Mart.

Hidalgo¹

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Nossa lealdade é para as espécies e para o planeta. Nossa obrigação de sobreviver não é apenas para nós, mas também para esse antigo e vasto cosmos a partir do qual derivamos Carl Sagan AgradecimentosA professora Déborah por me receber no Brasil, tanto orientadora como conselheira, sempre presente para escutar, guiar e compartilhar experiências.Ao Professor Marcelo Pena pelo conhecimento transmitido, o tempo dedicado nos fundamentos dos métodos espectrométricos e a boa atitude para resolver duvidas.À Paula Novaes pela ajuda no desenvolvimento dos ensaios fitotóxicos, além de estar preste a colaborar.À Mourisa que sempre está cuidando do laboratório e dos alunos que nele trabalham.À Aline pela ajuda no ajuste dos métodos desenvolvidos nos cromatógrafos.Ao Leandro por estar disposto a ajudar.Às queridas Priscila, que me ajudou bastante, em especial no uso do laboratório e no desenvolvimento de distintas metodologias usadas neste projeto, e Alice pelas dicas estatísticas, as conversas sobre espectrometria de massas e os momentos compartilhados.Aos meus amigos formados neste processo com os quais compartilhei trabalho e experiencias fora do laboratório Lucas, Wilton, Dalila, Cristiane, Cinthia, Carmen, Fernanda Anselmo, Janayna.Aos professores Antonio Salatino, Maria Luiza Salatino e Claudia Furlan, que estiveram abertos a ajudar quando fosse necessário.Ao Luís Doín pela amizade criada nestes anos no Brasil, as conversas, as músicas, as viagens e a paciência.A Natalia e Ricardo por me recever ao inicio deste processo na sua casa e me mostrar um pouco de como é São Paulo.Aos mis amigos de Piracicaba, em especial Amparo, Jake e Gaucho, com vocês compartilhei muitas experiências.A Camila Z, amiga de longo tempo com a qual sempre me sinto como em casa. E a Luana , uma grande amiga com um enorme coração.À querida Lina, minha luz no caminho, pela paciência nos días longos no laboratório, pelas palavras de ánimo, pelo carinho. Os dois aprendimos muito neste tempo no Brasil.Aos meus pais Edgar e Martha por dedicar a vida a minhãs irmãs e a mim, sempre dando carinho, sempre atentos, amo vocês e cada día sinto saudades.À minhas irmãs Ximena e Erika, meus cunhados Ignacio e Fabián e meus sobrinhos David, Isaac e Pablo porque dão a força para estar longe de casa e seguir superando barreiras culturais levando vocês no coração.Por ultimo e não menos importante, ao Brasil, a cada pessoa que encontrei nestes dois anos e fizeram desta experiência algo inesquescível Introdução geralAs plantas medicinais na história humana e seu metabolismo secundário Na busca de sustento e de suprir as necessidades de sobrevivência, os seres humanos têm usado a natureza como fonte de alimento, bem como uma fonte de produtos para curar ou aliviar doenças. Os primórdios do uso das plantas medicinais pelo homem foram instintivos como os animais, dado que na época não havia informações sobre quais plantas usar e para qual O conhecimento sobre as plantas específicas a serem utilizadas e os métodos de aplicação foram transmitidos através da história de f...

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Determination of the antibacterial activity of crude extracts and compounds isolated from Hortia oreadica (Rutaceae) against oral pathogens

Cited by 12 publications

References 12 publications

Antinociceptive and anti-inflammatory activities of the hexane extract from Hortia brasiliana Vand. leaves on experimental animal models

Antinociceptive and anti-inflammatory activities of the hexane extract from Hortia brasiliana Vand. leaves on experimental animal models

Chemical composition of essential oils of leaves, flowers and fruits of Hortia oreadica

Atividades biológicas dos alcaloides de Annona crassiflora Mart.

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