Determination of terazosin in human plasma, using high-performance liquid chromatography with fluorescence detection

A Specific High-Performance Thin-Layer Chromatography with Fluorescence Detection for the Determination of Some α1-Blockers

“…The recoveries of the studied a 1 -blockers from spiked human plasma were determined at three concentrations (12,30, and 80 ng=band) of spiked plasma samples. The results of the recovery studies are shown in Table 4.…”

“…[6,7] Recently, several analytical methods have been used for the determination of a 1 -blockers in bulk form, pharmaceutical formulations, and biological fluids. [8] These include spectrophotometry, [9][10][11] spectrofluorimetry, [12][13][14][15][16] thin-layer chromatography (TLC), [17,18] high-performance thinlayer chromatography (HPTLC), [19,20] high-performance liquid chromatography (HPLC) with UV, [21][22][23][24][25][26] fluorescence, [27][28][29][30] and mass detection. [31] Although two HPTLC methods were reported for the determination of a 1 -adrenergic blockers, this was the first HPTLC method to use fluorescence detection mode for the determination of a 1 -blockers.…”

Ionic Liquid Crystals Modifier for Selective Determination of Terazosin Antihypertensive Drug in Presence of Common Interference Compounds

“…Several methods for determination of this drug have been reported in the literature, including high performance liquid chromatography [5][6][7][8][9][10][11][12][13][14][15][16], capillary zone electrophoresis [17], spectrofluorimetry [18,19], X-ray fluorescence spectrometry based on the formation of ion-pair associates with zinc thiocyanate [20] and voltammetric methods [19,20]. Electrochemical methods have received considerable interest due to their higher selectivity, lower detection limit, lower cost and faster operation than other reported methods [21,22].…”

Validation and pharmacokinetic application of a method for determination of doxazosin in human plasma by high-performance liquid chromatography

“…Several methods have been described for the determination of doxazosin in human plasma (Fouda et al, 1988;Cowlishaw and Sharman, 1985;Jackman et al, 1991). Owing to the quinazoline structure, most of published assays for doxazosin and its members, prazosin, terazosin alfuzosin and tamsulosin, have been based on a high-performance liquid chromatography (HPLC) system with fluorescence detector (Cowlishaw and Sharman, 1985;Guinebault et al, 1986;Fouda et al, 1988;Jackman et al, 1991;Sekhar et al, 1998;Cheah et al, 2000;Macek et al, 2004). Although the method using special stationary phase, alumina-based column and glass-bead guard column with high-pH mobile phase was reported (Fouda et al, 1988), such columns may not be available in most laboratories and the mobile phase may deteriorate the columns and HPLC instrument.…”