Determination of temazepam and temazepam glucuronide by reversed-phase high-performance liquid chromatography

Kunsman, G.W.; Manno, Joseph E.; Przekop, M. A.; Manno, Barbara R.; Llorens, K.A.; Kunsman, C. M.

doi:10.1016/0378-4347(91)80180-k

Cited by 8 publications

(4 citation statements)

References 15 publications

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“…Plasma and urine glucuronide concentrations were also similar to those found in a previous study [Kunsman et al 1991c]. Plasma temazepam and glucuronide concentrations were significantly lower (Student's t-test) at 90 min for temazepam and at 90 and 150 min for temazepam glucuronide when temazepare was given in combination with ethanol than when it was given alone (Fig.…”

Section: Temazepam and Ternazepam Glucuronide Concentrationssupporting

confidence: 88%

“…The mean plasma temazepam concentration for the six subjects at 150 min was 372 (SD 144) ng-ml-1, similar to peak plasma concentrations in other studies [Greenblatt et al 1989;Kunsman et al 1991c]. Plasma and urine glucuronide concentrations were also similar to those found in a previous study [Kunsman et al 1991c].…”

Section: Temazepam and Ternazepam Glucuronide Concentrationssupporting

confidence: 86%

“…The delay in reaching peak temazepam plasma concentrations in this study compared with previous results [Kunsman et al 1991c] may be due to the consumption of 960 ml of cold orange juice or perhaps to an effect of ethanol on temazepam kinetics. Some previous studies have suggested that ethanol does not alter the kinetics of benzodiazepines but does increase their performance-impairing effects [Erwin et al 1986;Linnoila et al 1981].…”

Section: Temazepam and Temazepam Glucuronide Concentrationscontrasting

confidence: 54%

“…Previous studies have shown that the peak temazepam plasma concentration occurs at approximately 90 min [Greenblatt et al 1989;Kunsman et al 1991c;Schwarz 1979]. Here plasma temazepam concentrations continued to rise throughout the 3 h study.…”

Section: Temazepam and Temazepam Glucuronide Concentrationsmentioning

confidence: 75%

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The effects of temazepam and ethanol on human psychomotor performance

Kunsman

Manno

Przekop

et al. 1992

Eur J Clin Pharmacol

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We have studied the effects of temazepam, alone and in combination with ethanol, on psychomotor performance in six healthy men and women using a battery of five microcomputer-based tasks before and 30, 90, and 150 min after treatment. The tests were pursuit tracking, divided attention, two four-choice reaction time tests and tapping rate. The entire battery required 25 min. The subjects also reported their mood at each testing time using a computerized bipolar mood scales test. Temazepam (15 mg) plus ethanol (peak blood concentration of 11 mmol.l-1) significantly impaired divided attention, tracking, and reaction time over a 3 h period. There was significant impairment versus placebo for each drug alone on some of the tests. Plasma and urine concentrations of temazepam and temazepam glucuronide were measured, but there was no significant temporal correlation between impairment and drug or metabolite concentration in either plasma or urine. The subjects knew when they had taken ethanol, but could not discriminate temazepam from ethanol whether alone or in combination. The subjects rated their performance similarly after each of the four treatment conditions. The performance on the tracking, divided attention, and PAB reaction time tasks used in this study was impaired by a combination of temazepam and ethanol in doses which may not cause impairment when each is given alone.

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Section: Temazepam and Ternazepam Glucuronide Concentrationssupporting

confidence: 88%