Determination of Survival Rate and Its Effective Factors in Pediatric Leukemia in Hamadan Province During Years 2007 to 2016

Abstract

Background:The most common type of childhood cancer is leukemia, therefore, the aim of this study was to evaluate the survival rate and its effective factors in patients with malignancies under the age of 18 years in Hamadan province, during the years 2007 to 2016. Methods: In this historical cohort study, data were collected from the files of a hospital's archive of Hamadan province, and the log-rank test was used to compare the survival curves. Modeling of survival factors was done by using the Cox regression model. Results: The most frequent age group was 5 to 9 years old and there were 53 (37.9%) males and 86 (61.4%) females. The risk ratio for people with white blood cell count above 50000 to that of under 10000 was 2.260 (P value = 0.035) and for those with platelet levels above 50000 compared with those, who had levels less than 50000 was 0.376 (P value < 0.001). For the relapse rate, the risk ratio for those, who had relapses was 0.407 (P value = 0.031) when compared with those, who did not relapse. Conclusions:The results of this study were similar to that of similar studies in most of the examined cases, those with lower white blood count (WBC) count, and patients with high blood platelets had a higher survival rate than those with a lower risk profile. Regarding the variable relapse status, less survival was reported for those, who had relapses than those, who did not show relapse.

Evaluation of Risk Factors for Pediatric Cancers in the West of Iran

“…Given that the population of boys is slightly higher than that of girls in our province, it seems to be logical. The results are consistent with Eghbalian et al's study (17).…”