Determination of Sulfonamides in Bovine Milk by Ultra Performance Liquid Chromatography Combined with Quadrupole Mass Spectrometry

She, Yongxin; Li, Jiajia; Wang, Jing; Liu, Yong; Wang, Rongyan; Cao, Weiqiang

doi:10.1080/00032711003698796

Cited by 11 publications

(4 citation statements)

References 20 publications

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“…DON could not be extracted well by the other three solvents (56.3–73.2%). These results agree with the findings of She et al [ 33 ] and Chen et al [ 23 ].…”

Section: Resultssupporting

confidence: 94%

“…Therefore, it is not easy to extract mycotoxins from dried seafood matrices with low interference and high recovery. UAE is an effective extraction method widely used in determining mycotoxin residues in food products [ 32 , 33 , 34 ]. However, due to the differences in the matrices of the seafoods tested, it was necessary to optimize this extraction method for our purpose.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Simultaneous Quantification of Aflatoxin B1, T-2 Toxin, Ochratoxin A and Deoxynivalenol in Dried Seafood Products by LC-MS/MS

Deng

Wang

Deng

et al. 2020

Toxins

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Mycotoxins are secondary metabolites produced by fungi. These contaminate dried seafoods during processing and storage and represent a potential health hazard for consumers. A sensitive, selective and accurate liquid chromatography/tandem mass spectrometry (LC-MS/MS) method was established for simultaneous quantification of four common mycotoxins (aflatoxin B1 (AFB1), T-2 toxin (T-2), ochratoxin A (OTA) and deoxynivalenol (DON)) in dried shrimp, dried fish and dried mussel products. Mycotoxins were extracted from dried seafood samples by acetonitrile/water (85/15, v/v), subjected to ultrasound for 60 min at 20 °C and cleaned up by defatting with n-hexane. The sample matrix affected the linearity of detection (R2 ≥ 0.9974). The limit of detection (LOD) and limit of quantification (LOQ) in dried seafood products varied from 0.1 to 2.0 µg·kg−1 and 0.3 to 5.0 µg·kg−1, respectively. The method was validated by spiking samples with specific mycotoxin levels, and the recoveries, intra-relative standard deviation (RSDs) and inter-RSDs ranged between 72.2–98.4%, 2.8–10.6%, and 5.5–15.4%, respectively. This method was used to analyze 40 dried seafood products purchased from the Zhanjiang seafood market. Results of this product sampling showed that while no DON was detected, AFB1, T-2 and OTA were detected in 30.8%, 17.5% and 33.3% of the samples, respectively. AFB1, T-2 and OTA concentrations varied at 0.58–0.89, 0.55–1.34 and 0.36–1.51 µg·kg−1, respectively. Relatively high frequency of contamination and the presence of AFB1, OTA and T-2 residues indicate the need to monitor mycotoxins in dried seafood products.

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“…DON could not be extracted well by the other three solvents (56.3–73.2%). These results agree with the findings of She et al [ 33 ] and Chen et al [ 23 ].…”

Section: Resultssupporting

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Simultaneous Quantification of Aflatoxin B1, T-2 Toxin, Ochratoxin A and Deoxynivalenol in Dried Seafood Products by LC-MS/MS

Deng

Wang

Deng

et al. 2020

Toxins

View full text Add to dashboard Cite

show abstract

“…The recovery rate of majority pesticides was between 70% and 120%, the detection and quantification range were 0.10 mg/kge56.77 mg/kg and 0.33 mg/kge189.23 mg/kg, respectively. In the research carried out by She, Liu, and Wang (2008) has been introduced a method to determinate 24 kinds of sulfa drug residues in milk by ultra performance liquid chromatographyequadrupole mass spectrometry (UPLC-MS/MS). With this method they could get results within 10 min with high recovery rate and sensitivity.…”

Section: Liquid Chromatography Fingerprintingmentioning

confidence: 99%

Review of the current application of fingerprinting allowing detection of food adulteration and fraud in China

Zhang

Dediu

et al. 2011

Food Control

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“…In recent years, many methods have been developed to detect SM2, including high‐performance liquid chromatography (HPLC), [8–11] HPLC‐MS/MS, [12–16] UHPLC‐MS/MS, [17–18] capillary electrophoresis (CE), [19–21] microfluidic chip electrophoresis [22] and enzyme‐linked immunosorbent assay (ELISA) [23–24] . Although these techniques have achieved satisfactory results, some of them are also time consuming and cumbersome.…”

Section: Introductionmentioning

confidence: 99%

A Novel Electrochemical Immunosensor For Sulfadimidine Detection Based On Staphylococcal Protein A−AuNPs/Ag−GO−Nf Modified Electrode[]**

et al. 2021

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Sulfadimidine (SM2) is a kind of synthetic sulfadiazine antibiotics. Excessive use of SM2 in animal breeding can lead to animal‐derived food residues, which will bring potential risks to human health. Herein, a sensitive label‐free electrochemical immunosensor using silver nanoparticles (AgNPs) as redox probe was developed for the specific detection of SM2. Firstly, the Ag−GO nanocomposites were prepared by in‐situ reduction of AgNPs on graphene oxide (GO) surface with glucose. Gold nanoparticles (AuNPs) were reduced on the surface of Ag−GO nanocomposites by permanent electrodeposition. Staphylococcal protein A (SPA) was dripped onto the AuNPs modified electrode to absorb antibody (anti‐SM2). Herein, GO provided a large surface area for assembling a large number of AgNPs with redox activity. AuNPs were used to immobilize SPA and amplify the electrochemical signal. In addition, SPA with antibody targeting function was introduced to improve the efficiency of immune response. Under optimal conditions, the label‐free immunosensor showed a linear range of 63 pg/mL to 20 ng/mL with a limit of detection (LOD) of 3 pg/mL (S/N=3). Finally, the developed method showed excellent performance in practical application, which provided a promising possibility for the detection of other veterinary drug residues in animal derived food.

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Determination of Sulfonamides in Bovine Milk by Ultra Performance Liquid Chromatography Combined with Quadrupole Mass Spectrometry

Cited by 11 publications

References 20 publications

Simultaneous Quantification of Aflatoxin B1, T-2 Toxin, Ochratoxin A and Deoxynivalenol in Dried Seafood Products by LC-MS/MS

Simultaneous Quantification of Aflatoxin B1, T-2 Toxin, Ochratoxin A and Deoxynivalenol in Dried Seafood Products by LC-MS/MS

Review of the current application of fingerprinting allowing detection of food adulteration and fraud in China

A Novel Electrochemical Immunosensor For Sulfadimidine Detection Based On Staphylococcal Protein A−AuNPs/Ag−GO−Nf Modified Electrode[]**

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