Determination of sulfonamide residues in water samples by in-line solid-phase extraction-capillary electrophoresis

Lara, Francisco J.; Garcı́a-Campaña, Ana M.; Neusüß, Christian; Alés-Barrero, Fermín

doi:10.1016/j.chroma.2009.01.097

Cited by 65 publications

(54 citation statements)

References 78 publications

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“…Currently, various methods, such as liquid chromatography, [6][7][8][9][10][11][12] capillary electrophoresis, [13][14][15][16] gas chromatography (GC), [17][18][19] micellar electrokinetic capillary chromatography, [19][20][21][22] and liquid mass chromatography, 23,24 have been proposed for analyzing SAs residue in food. These techniques have been proved to be suitable and sensitive for SAs detection.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Determination of Sulfonamides with a Modified Glassy Carbon Electrode Using Carboxyl Multiwalled Carbon Nanotubes

Chen

2016

Journal of the Brazilian Chemical Society

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New glassy carbon electrode (GCE) modified with carboxyl multiwalled carbon nanotubes (MWCNTs) and treated with ultrasonic dispersing in N,N-dimethylfomamide (DMF) media, namely DMF/carboxyl/MWCNTs/GCE, was prepared for electrochemical determination of sulfonamides (SAs). Electrochemical behavior of SAs based on DMF/carboxyl/MWCNTs/GCE was investigated by cyclic voltammetry and impedance spectroscopy. The effects of various experimental parameters on the response of electrode such as pH of buffer, scan rate and the amount of modification were optimized. Under the optimal conditions, the obtained sensor presented linear response to SAs in the range of 5.0 × 10 −7 to 1.1 × 10 −4 mol L −1 of sulfonamide (R = 0.999), sulfamethazine (R = 0.990), sulfadiazine (R = 0.997), sulfamethoxazole (R = 0.996) and the limits of detection of 1. 65 × 10 −8 , 3.19 × 10 −8 , 6.76 × 10 −8 and 9.41 × 10 −8 mol L −1 , respectively. The recoveries were in the range of ca. 85-103% with relative standard deviation (RSD) < 5%. The sensor was tested by cyclic voltammetry with repeatability and stability of more than 90% of its original activity. The proposed method might offer feasibility and applicability of the sensor for further complex sulfonamides compounds.Keywords: voltammetric determination, carboxyl, multiwalled carbon nanotubes, sulfamethazine, sulfamethoxazole Introduction Sulfonamides (SAs) have a broad spectrum of antibacterial activity and play an important role as effective chemotherapeutics in bacterial. The structures of SAs consist of benzene ring with amine group (NH 2 ) at a C4 position and sulfonic acid with different alkyl groups (Figure 1). They are widely used in animal husbandry with the purpose to prevent the growth of bacteria, to treat the infections from certain protozoa and microorganisms 1,2 and to increase their production.3 As an additive of preventing bacterial in animal feed, 4 SAs, however, would bring potential consequences with unauthorized use.3 The drug residues in foods, such as milk and meat, may cause allergic reactions, antibiotic resistance and even cancer. Many countries including China have established maximum residue limits (MRLs) for SAs at the total level of 100 μg kg −1 in animal meat. 5Consequently, it is of grave importance to develop a rapid, sensitive, and accurate method for monitoring the level of SAs residues in animal meat.Currently, various methods, such as liquid chromatography, 6-12 capillary electrophoresis, 13-16 gas chromatography (GC), 17-19 micellar electrokinetic capillary chromatography, [19][20][21][22] and liquid mass chromatography, 23,24 have been proposed for analyzing SAs residue in food. These techniques have been proved to be suitable and sensitive for SAs detection. Nonetheless, some of these methods are expensive, time-consuming and tedious, and in some cases the limits of detection is not acceptable. Recently, a research on high-performance liquid chromatography (HPLC), which was coupled with photodiode array detector and mass spectrometry, studied for the...

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Section: Introductionmentioning

confidence: 99%

Voltammetric Determination of Sulfonamides with a Modified Glassy Carbon Electrode Using Carboxyl Multiwalled Carbon Nanotubes

Chen

2016

Journal of the Brazilian Chemical Society

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“…Therefore, analysis of SAs residues in the environmental water has drawn increasing concerns. At present, a lot of methods such as enzyme immunoassays [31,32], high performance liquid chromatography (HPLC) [33][34][35][36], gas chromatography [37], and capillary electrophoresis [38] have been used to determine SAs. However, preconcentration and cleanup are usually required prior to determination of SAs due to relatively low SAs concentration in water samples and relative complexity of environmental water matrices.…”

Section: Introductionmentioning

confidence: 99%

Hexafluoroisopropanol-induced coacervation in aqueous mixed systems of cationic and anionic surfactants for the extraction of sulfonamides in water samples

Chen

Zhang

et al. 2014

Anal Bioanal Chem

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Hexafluoroisopropanol (HFIP)-induced coacervation in aqueous mixed systems of catanionic surfactants of dodecyltrimethylammonium bromide (DTAB) and sodium dodecyl sulfate (SDS) was described in detail, and its application in the extraction of strongly polar sulfonamides (SAs) was investigated. With 10 % (v/v) HFIP inclusion, coacervation formation and two-phase separation occur in a wide range of SDS/DTAB mole ratios (88:12∼0:100 mol/mol) and total surfactant concentrations (10∼200 mmol/L). The interactions between HFIP and DTAB play an important role in coacervation formation. The HFIP-induced SDS-DTAB coacervation extraction proves to be an efficient method for the extraction and preconcentration of SAs. Both hydrophobic interaction and polar interactions (hydrogen-bond, electrostatic, and π-cation) contribute to the distribution of SAs into coacervate phase. The proposed HFIP-induced SDS-DTAB coacervation extraction combined with HPLC-UV was employed for the extraction and quantitative determination of SAs in environmental water samples. Limits of detection were 1.4∼2.5 ng mL(-1). Excellent linearity with correlation coefficients from 0.9990 to 0.9995 was obtained in the concentration of 0.01∼10 μg mL(-1). Relative recoveries were in the range of 93.4∼105.9 % for analysis of the lake, underground, and tap water samples spiked with SAs at 0.01, 1.0, and 10 μg/mL, respectively. Relative standard deviations were 0.7∼3.2 % for intraday precision and 1.3∼4.6 % for interday precision (n = 3). Concentration factors were 17∼49 for three water samples spiked with 0.01 μg/mL SAs. The results demonstrate that the proposed extraction method is feasible for the preconcentration and determination of trace SAs in real water samples.

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“…There are several designs reported in the literature for the construction of the in-line SPE concentrator, such as open-tubular columns [26], small packed beds [27,28], disks [29] and monolithic materials [30]. The most common approach for in-line SPE-CE designs is the use of small packed beds.…”

Section: Introductionmentioning

confidence: 99%

“…In this setup, the packing material is usually retained by frits near the inlet end of the capillary in order to prevent small-diameter particles from passing through the separation capillary. The most commonly used sorbents in this approach are Oasis HLB, Oasis MCX and C18 [27,28,31,32]. For example, Benavente et al [32] described the development of an in-line SPE-CE method for the analysis of peptides in diluted standard solutions using mass spectrometry detection.…”

Section: Introductionmentioning

confidence: 99%

“…To solve these issues, some authors have adopted a strategy in which the particle size of the sorbent is a key parameter. If the particle size of the material is large enough, the use of frits can be avoided [27]. For example, Saavedra et al [34] used Oasis MCX in the construction of a frit-free concentrator device for the determination of 3-nitro-L-tyrosine in biological samples by capillary electrophoresis.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of in‐line solid‐phase extraction capillary electrophoresis for the analysis of drugs of abuse and their metabolites in water samples

et al. 2012

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In this study, in-line solid-phase extraction (SPE) was used as an enrichment technique in combination with CE for the preconcentration and separation of 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), cocaine (COC), codeine (COD) and 6-acetylmorphine (6AM). The separation buffer (BGE) used was 80 mM disodium phosphate anhydrous and 6 mM of HCl (final BGE pH of 3). The SPE extractor consists of a small segment of capillary filled with Oasis HLB sorbent and inserted into the inlet section of the electrophoretic capillary. Different parameters affecting preconcentration were evaluated, such as sample pH, the volume of the elution plug and sample injection time. The detection limits (LODs) reached for standard samples by in-line SPE-CE-UV ranged between 50 and 200 ng/L, with sensitivity enhancement factors ranging from 2300 to 5300. Reproducibility values (expressed in terms of relative standard deviation) were below 7.6% for standard samples. This is a simple and an effective method for the determination of the studied drugs of abuse and their metabolites. The applicability of the developed method was demonstrated in tap and river water samples which were directly analyzed without any off-line pretreatment. Analytical parameters were evaluated and LODs were between 70 and 270 ng/L with relative recoveries between 85 and 97%.

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Determination of sulfonamide residues in water samples by in-line solid-phase extraction-capillary electrophoresis

Cited by 65 publications

References 78 publications

Voltammetric Determination of Sulfonamides with a Modified Glassy Carbon Electrode Using Carboxyl Multiwalled Carbon Nanotubes

Voltammetric Determination of Sulfonamides with a Modified Glassy Carbon Electrode Using Carboxyl Multiwalled Carbon Nanotubes

Hexafluoroisopropanol-induced coacervation in aqueous mixed systems of cationic and anionic surfactants for the extraction of sulfonamides in water samples

Investigation of in‐line solid‐phase extraction capillary electrophoresis for the analysis of drugs of abuse and their metabolites in water samples

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