2022
DOI: 10.1038/s41598-022-16564-x
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Determination of starting dose of the T cell-redirecting bispecific antibody ERY974 targeting glypican-3 in first-in-human clinical trial

Abstract: Currently, ERY974, a humanized IgG4 bispecific T cell-redirecting antibody recognizing glypican-3 and CD3, is in phase I clinical trials. After a first-in-human clinical trial of an anti-CD28 agonist monoclonal antibody resulting in severe life-threatening adverse events, the minimal anticipated biological effect level approach has been considered for determining the first-in-human dose of high-risk drugs. Accordingly, we aimed to determine the first-in-human dose of ERY974 using both the minimal anticipated b… Show more

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Cited by 2 publications
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“…In foundational BiTE studies, GPC3 has similarly served as a starting point for targeting. Thus far, ERY974, a humanized IgG4 bispecific T-cell-redirecting antibody recognizing GPC3 and CD3, was investigated in a phase I trial in which an appropriate dosage was administered without any adverse events [97]. As a final note, the introduction of agents acting through mechanisms other than VEGF inhibition or immune enhancement could be helpful for patients who have contra-indications to either approach (e.g., those with prior transplants and cardiovascular or bleeding risks).…”
Section: Emerging Treatment Strategiesmentioning
confidence: 99%
“…In foundational BiTE studies, GPC3 has similarly served as a starting point for targeting. Thus far, ERY974, a humanized IgG4 bispecific T-cell-redirecting antibody recognizing GPC3 and CD3, was investigated in a phase I trial in which an appropriate dosage was administered without any adverse events [97]. As a final note, the introduction of agents acting through mechanisms other than VEGF inhibition or immune enhancement could be helpful for patients who have contra-indications to either approach (e.g., those with prior transplants and cardiovascular or bleeding risks).…”
Section: Emerging Treatment Strategiesmentioning
confidence: 99%