Determination of stability constants of inclusion complexes of betulin derivatives with β-cyclodextrin by capillary electrophoresis

Попова, О. В.; Sursyakova, Viktoria V.; Burmakina, Galina V.; Levdansky, Vladimir A.; Rubaylo, Anatoly I.

doi:10.1134/s0012500815030039

Cited by 21 publications

(21 citation statements)

References 9 publications

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“…CE has advantages such as rapidity, high selectivity, small value of samples, and low operating costs. The most used approach is mobility shift ACE . In this method, binding constants are determined based on the change in electrophoretic mobilities of the studied compounds with varying the ligand content in BGE.…”

Section: Introductionmentioning

confidence: 99%

“…Data on the thermodynamic parameters of the complexation of betulin derivatives with CDs in aqueous solutions are fragmentary. Recently, the interaction of betulin derivatives with β‐CD and with (2‐hydroxypropyl)‐β‐cyclodextrin and HP‐γ‐CD has been studied using ACE and PS‐CZE. The binding (stability) constants of the complexes were determined at 25°C.…”

Section: Introductionmentioning

confidence: 99%

“…It was observed that (2‐hydroxypropyl)‐β‐cyclodextrin did not form complexes with BOA and betulinic acid (BIA). This is probably caused by steric hindrances from hydroxypropyl groups because it was previously shown that the acids formed complexes with β‐CD .…”

Section: Introductionmentioning

confidence: 99%

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Thermodynamic parameters for the complexation of water‐insoluble betulin derivatives with (2‐hydroxypropyl)‐γ‐cyclodextrin determined by phase‐solubility technique combined with capillary zone electrophoresis

2019

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The complexation of betulinic and betulonic acids (BIA and BOA) (pentacyclic lupane triterpenoids) with (2‐hydroxypropyl)‐γ‐cyclodextrin (HP‐γ‐CD) was studied at different temperatures using the method combining phase‐solubility technique and CZE. In contrast to mobility shift ACE utilizing the electrophoretic mobility, in this approach, the peak areas are used. The apparent binding (stability, formation) constants are obtained by the Higuchi and Connors method from the linear segment of compound solubility diagrams in CD solutions. It was found that the apparent binding constants of the HP‐γ‐CD complexes of BIA and BOA decrease with increasing temperature. The binding constants of BOA complexes are slightly higher than those of BIA complexes; this can be explained by difference in the hydration degrees of carbonyl and hydroxyl groups. On the basis of the binding constants obtained and their temperature dependences (van't Hoff plot), the enthalpy as well as entropy changes and Gibbs free energies were calculated. It was found that the complexation was characterized by negative changes of enthalpy and entropy, that is, it was controlled by enthalpy changes. The results obtained can be used for the optimization of microcapsulation processes of BOA and BIA with the HP‐γ‐CD application in order to increase solubility and bioavailability of these compounds.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Thermodynamic parameters for the complexation of water‐insoluble betulin derivatives with (2‐hydroxypropyl)‐γ‐cyclodextrin determined by phase‐solubility technique combined with capillary zone electrophoresis

2019

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“…Ранее [12] нами был предложен способ исследования методом КЭ комплексов, образованных практически нерастворимыми соединениями, в частности комплексов включения бетулоновой кислоты с β-ЦД.…”

Section: Introductionunclassified

Solubility Study of Betulonic Acid in the Presence of Hydroxypropyl-γ-cyclodextrin by Capillary Electrophoresis

Попова¹,

Sursyakova²,

Burmakina³

et al. 2016

J. Sib. Fed. Univ. Chem.

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“…CE appeared in the 1980s and was rapidly developed due to transition to the silica capillaries with very small and regular diameters (tens of micrometers) and application of the straight detection in the fluid flow [22]. The CE and related electroseparation techniques are widely used for the estimation of stability constants because of rapidity, low cost of reagents, and high performance [23][24][25][26][27][28][29][30][31]. To study the interactions between a metal and ligand, several electropherograms are recorded with varying ligand content in background electrolytes (BGE) and metal solution injected as a sample.…”

Section: Introductionmentioning

confidence: 99%

Composition and stability constants of copper(II) complexes with succinic acid determined by capillary electrophoresis

Sursyakova

Burmakina

Rubaylo

2016

Journal of Coordination Chemistry

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Fax: 73912494108 2 Composition and stability constants of copper(II) complexes with succinic acid ions determined by capillary electrophoresisThe advantage of usage of capillary electrophoresis technique was demonstrated for studying a complicated system owing to the dependence of direction and velocity of the electrophoretic movement on the charge of complex species. The stability constants of copper(II) complexes with ions of succinic acid were determined by capillary electrophoresis, including the 1:2 metal to ligand complexes which are rarely mentioned and taken into account in studies during recent years. The measurements were carried out at 25 ºC and ionic strength of 0.1, obtained by mixing the solutions of succinic acid and lithium hydroxide up to рН 4.2 -6.2. It was shown that while pH was more than 4.5 the zone of copper(II) complexes with succinate ions moves as an anion. It is impossible to treat this fact using only the complexes with a metal-ligand ratio of 1:1 (CuL 0 , CuHL + ).The following values of stability constants were obtained: log β(CuL) = 2.89 ± 0.02, log β(CuHL + ) = 5.4 ± 0.5, log β(CuL 2 2-) = 3.88 ± 0.05, log β(CuHL 2 -) = 7.2 ± 0.3.

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Determination of stability constants of inclusion complexes of betulin derivatives with β-cyclodextrin by capillary electrophoresis

Cited by 21 publications

References 9 publications

Thermodynamic parameters for the complexation of water‐insoluble betulin derivatives with (2‐hydroxypropyl)‐γ‐cyclodextrin determined by phase‐solubility technique combined with capillary zone electrophoresis

Thermodynamic parameters for the complexation of water‐insoluble betulin derivatives with (2‐hydroxypropyl)‐γ‐cyclodextrin determined by phase‐solubility technique combined with capillary zone electrophoresis

Solubility Study of Betulonic Acid in the Presence of Hydroxypropyl-γ-cyclodextrin by Capillary Electrophoresis

Composition and stability constants of copper(II) complexes with succinic acid determined by capillary electrophoresis

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