Determination of Solubility Parameters of Ibuprofen and Ibuprofen Lysinate

Abstract

Abstract:In recent years there has been a growing interest in formulating solid dispersions, which purposes mainly include solubility enhancement, sustained drug release and taste masking. The most notable problem by these dispersions is drug-carrier (in)solubility. Here we focus on solubility parameters as a tool for predicting the solubility of a drug in certain carriers. Solubility parameters were determined in two different ways: solely by using calculation methods, and by experimental approaches. Six different calculation methods were applied in order to calculate the solubility parameters of the drug ibuprofen and several excipients. However, we were not able to do so in the case of ibuprofen lysinate, as calculation models for salts are still not defined. Therefore, the extended Hansen's approach and inverse gas chromatography (IGC) were used for evaluating of solubility parameters for ibuprofen lysinate. The obtained values of the total solubility parameter did not differ much between the two methods: by the extended Hansen's approach it was δt = 31.15 MPa 0.5 and with IGC it was δ t = 35.17 MPa 0.5 . However, the values of partial solubility parameters, i.e., δ d , δ p and δ h , did differ from each other, what might be due to the complex behaviour of a salt in the presence of various solvents.

Modeling of Hansen's solubility parameters of aripiprazole, ziprasidone, and their impurities: A nonparametric comparison of models for prediction of drug absorption sites

“…The reference values of Hansen's solubility parameters were retrieved from Terada and Marchessault and Hansen . Hansen's solubility parameter values for ibuprofen and ibuprofen lysinate were determined by extended Hansen solubility approach (EHSA) and inversion gas chromatography (IGC), respectively.…”

“…The reference values of Hansen solubility parameters are taken from the literature and are included in Table , along with the estimation and determination methods. Practically, experimentally obtained data were provided only in the case of ibuprofen and ibuprofen lysinate, using the extended Hansen's solubility approach and the inverse gas chromatography, respectively . For the rest of compounds, the values are obtained by a reliable fragmentation method .…”

Application of Multivariate Adaptive Regression Splines (MARSplines) for Predicting Hansen Solubility Parameters Based on 1D and 2D Molecular Descriptors Computed from SMILES String

“…Applications of MARSplines Models. One of the most often used and direct applications of Hansen solubility parameters is the selection of appropriate solvent for solubilization or dispergation of di erent solids and materials including drugs [22][23][24][25][26], polymers [5][6][7][8][9], herbicides [7], pigments and dyes [3,18], and biomaterials [99]. It is typically done by computing HSP parameters based on a series of solubility measurements.…”

“…By calculating the Euclidean distance between two points in the Hansen space, one can evaluate the miscibility of two substances according to the commonly known rule "similia similibus solvuntur." ere are many scientific and industrial fields of Hansen solubility parameters application, including polymer materials, paints, and coatings (e.g., miscibility and solubility [5][6][7][8][9], environmental stress cracking [10,11], adhesion [12], plasticizers compatibility [13], swelling, solvent diffusion, and permeation [14,15], and polymer sensors designing [16], pigments and nanomaterials dispersibility [3,[17][18][19][20]), membrane filtration techniques [21], and pharmaceutics and pharmaceutical technology (e.g., solubility [22][23][24][25][26][27], cocrystal screening [28,29], drug-DNA interaction [30], drug's absorption site prediction [31], skin permeation [32], drug-nail affinity [33], drug-polymer miscibility, and hot-melt extrusion technology [34][35][36][37]).…”

Influence of Water Molecules on the Detection of Volatile Organic Compounds (VOC) Cancer Biomarkers by Nanocomposite Quantum Resistive Vapor Sensors vQRS

“…The chemo-resistive responses of three different vQRS prepared by M2, PVP-CNT, PS-CNT, and PP-CNT have been recorded during their exposure to the five selected VOC biomarkers and water at saturation as seen in Figure 3, using the experimental setup described in Figure 1a,b. The vQRS matrices PVP, PS, and PP have been selected for their solubility parameters δt (see Table 1) close to those of the analytes recalled in Table 2, expected to result in good intermolecular interactions [61,62] (expressed by a small value of the χ 12 Flory-Huggins parameter of Equation (2)) and therefore large responses that can be correlated by an exponential law to χ 12 [63][64][65][66].…”