Determination of Simvastatin by Voltammetry Method at Screen-Printed Electrode Modified by Graphene Oxide Nanosheets and Sodium Dodecyl Sulfate

Abstract

An accurate, rapid, simple, and novel technique was developed to determine simvastatin (SMV). In this research, a screen-printed electrode (SPE) was deposited with graphene oxide (GO) and sodium dodecyl sulfate (SDS), respectively. For the first time, the handmade modified SPE measured the SMV by differential pulse voltammetry (DPV) with high sensitivity and selectivity. The results of cyclic voltammetry indicated the oxidation irreversible process of SMV. Various parameters (pH, concentration, scan rate, support electrolyte) were performed to optimize the conditions for the determination of SMV. Under the optimum experiment condition of 0.1 M KNO3 as support electrolyte and pH 7.0, the linear range was achieved for SMV concentration from 1.8 to 36.6 µM with a limit of detection (LOD), and a limit of quantitation (LOQ) of 0.06 and 1.8 µM, respectively. The proposed method was successfully utilized to determine SMV in tablets and urine samples with a satisfactory recovery in the range of 96.2 to 103.3%.

Quantification of Statins in Pharmaceutical Products Using Screen-Printed Sensors Based of Multi-Walled Carbon Nanotubes and Gold Nanoparticles

“…In the case of rosuvastatin, it was observed that the current intensity decreases with increasing pH, while for simvastatin, the highest and well-defined current was obtained at pH = 7.0 (Figures 3 and S4). These results are consistent with previously published studies [44,45]. As can be seen, an oxidation process was triggered at 0.58 V for SPCE and 0.65 V for AuNP-MWCNTs/SPCE during anodic scanning.…”

“…Moreover, the results demonstrate the feasibility of the voltammetric method for the analysis of the two statins. The obtained values are similar or even better than those reported in the literature [6,[27][28][29]44,49,50] (Table 4), which proves that the AuNP-MWCNTs/SPCE sensor has adequate electroanalytical performance for RV and SV quantification in actual samples. The association of carbon nanotubes and gold nanoparticles demonstrated in all stages of the study that it is an efficient way to improve the electrochemical performance of the modified sensor.…”

Waste-derived carbon nanodots for fluorimetric and simultaneous electrochemical detection of heavy metals in water

“…Current knowledge reveals several techniques for detecting heavy metal ions in water, but fluorescent probes and electrochemical sensors still represent the best choice owing to their numerous advantages such as low cost, rapid response time, biocompatibility, and ease of modification. 5,6 Chemical processes including oxidation and photodegradation have associated issues such as high costs and energy consumption, with the risk of undesired by-products. 7 Biological methods, i.e.…”