Determination of Shikonin and Rosmarinic Acid in <i>Echium vulgare</i> L. and <i>Echium russicum</i> J.F. Gmel. by Capillary Electrophoresis

Dresler, Sławomir; Kubrak, Tomasz; Bogucka‐Kocka, Anna; Szymczak, Grażyna

doi:10.1080/10826076.2014.951767

Cited by 30 publications

(16 citation statements)

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“… 2002 and references therein), E. vulgare and E. russicum (Dresler et al. 2015 ). Several therapeutic effects of shikonin and its derivatives were previously noted, including antitumor, anti-inflammatory and antimicrobial activities (Chen et al.…”

Section: Resultsmentioning

confidence: 99%

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Comparison of some secondary metabolite content in the seventeen species of the Boraginaceae family

Dresler

Szymczak

Wójcik

2017

Pharmaceutical Biology

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Context: The Boraginaceae family comprises plants that have important therapeutic and cosmetic applications. Their pharmacological effect is related to the presence of naphthaquinones, flavonoids, terpenoids, phenols, or purine derivative – allantoin.Objective: In the present study, comparison of some secondary metabolite content and phytochemical relationship between 17 species of the Boraginaceae family were analyzed.Materials and methods: High performance capillary electrophoresis (HPCE) was used to perform a chemometric analysis in the following Boraginaceae species: Anchusa azurea Mill., Anchusa undulata L., Borago officinalis L., Buglossoides purpurocaerulea (L.) I.M. Johnst., Cerinthe minor L., Cynoglossum creticum Mill, Echium italicum L., Echium russicum J.F. Gmel., Echium vulgare L., Lindelofia macrostyla (Bunge) Popov (syn. Lindelofia anchusoides (Lindl.) Lehm.), Lithospermum officinale L., Nonea lutea (Desr.) DC., Omphalodes verna Moench (syn. Cynoglossum omphaloides L.), Pulmonaria mollis Wulfen ex Hornem., Pulmonaria obscura Dumort., Symphytum cordatum Waldst. & Kit ex Willd., and Symphytum officinale L.Results: Six active compounds in shoot extracts (allantoin, p-hydroxybenzoic acid, rutin, hydrocaffeic acid, rosmarinic acid, and chlorogenic acid) and four compounds in root extracts (allantoin, hydrocaffeic acid, rosmarinic acid, and shikonin) were identified. The presence and abundance of these compounds were used for the characterization of the species and for revealing their phytochemical similarity and differentiation.Discussion and conclusion: The present study provides the first comprehensive report of the extraction and quantification of several compounds in Boraginaceae species (some of them for the first time). Among the 17 species studied, species with potentially high pharmacological activity were recognized.

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Section: Resultsmentioning

confidence: 99%

“…The separation was performed according to the modified method described previously (Dresler et al. 2015 ). Briefly, fused silica 50 μm i.d.…”

Section: Methodsmentioning

confidence: 99%

Comparison of some secondary metabolite content in the seventeen species of the Boraginaceae family

Dresler

Szymczak

Wójcik

2017

Pharmaceutical Biology

Self Cite

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“…Aboveground parts of Echium vulgare plants were collected in August 2014. The extraction was performed according to Dresler et al (). Briefly, 1‐g samples of air‐dry shoot material were powdered and extracted three times with a fresh portion (10 mL) of decreasing concentrations of methanol (100%, 80%, 60%) in an ultrasonic bath for 30 min at a temperature below 40 °C.…”

Section: Methodsmentioning

confidence: 99%

“…An Agilent 7100 HPCE system equipped with a diode‐array detector (UV–vis, DAD, 190–600 nm) (Agilent Technologies, Santa Clara, CA, USA) was used for capillary electrophoresis analysis. The separation was carried out according to the slightly modified method described before (Dresler et al , ). Briefly, a fused‐silica capillary of 50 μm i.d.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, Echium plants are rich in secondary metabolites, e.g. pyrrolizidine alkaloids – echimidine and its derivatives (El‐Shazly et al , ), naphthoquinone pigments – shikonin derivatives (Papageorgiou et al , ), phenolic acids – rosmarinic acid (Dresler et al, ). In addition to these compounds, we have identified the presence of chlorogenic acid, p ‐hydroxybenzoic acid, hydrocaffeic acid, flavonoid – rutin, and allantoin (unpublished results).…”

Section: Introductionmentioning

confidence: 99%

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