Determination of serum diltiazem concentrations in a pharmacokinetic study using gas chromatography with electron capture detection

Alebic-Kolbah, Tanja; Plavsić, F

doi:10.1016/0731-7085(90)80142-c

Cited by 11 publications

(7 citation statements)

References 9 publications

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“…Steadystate plasma diltiazem concentrations were 141 6 56 ng/mL. The authors concluded that diltiazem [76][77][78] significantly decreased resting HR but not BP in healthy volunteers. Diltiazem decreased both hemodynamic variables during exercise; thus, the hemodynamic effects of diltiazem are more profound during exercise and may be more useful surrogate markers for calcium antagonists and other cardiovascular agents in healthy volunteer studies.…”

Section: Pharmacokineticsmentioning

confidence: 92%

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Chiral Cardiovascular Drugs

Ranade¹,

Somberg

2005

American Journal of Therapeutics

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Stereochemistry in drug molecules is rapidly becoming an important aspect in drug research, design, and development. Recently, individual stereoisomers of drug molecules with asymmetric centers such as fexofenadine, cetirizine, verapamil, fluoxetine, levalbutarol, and amphetamine, for example, have been separated and developed as individual drugs. These stereoisomers have different therapeutic activity, and each isomer has contributed differently with respect to its formulation's pharmacologic activity, side effects, and toxicity. The present overview discusses chirality among a select group of cardiovascular drugs, their stereochemical synthesis/preparation, isolation techniques using chiral chromatography, methods for confirmation of their enantiomeric purity, pharmacodynamics, and pharmacokinetics. Chirality has been visualized as an important factor in cardiovascular research. It is also becoming evident in other areas of therapeutics.

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Section: Pharmacokineticsmentioning

confidence: 92%

“…Both N-demethyldiltiazem and desacetyldiltiazem have been shown to have pharmacologic activity in animal tissues. It is therefore possible that these metabolites contribute to the pharmacologic effect of diltiazem, but this possibility, according to the authors, [76][77][78] has not been explored.…”

Section: Pharmacokineticsmentioning

confidence: 95%

Chiral Cardiovascular Drugs

Ranade¹,

Somberg

2005

American Journal of Therapeutics

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“…Previous methods for the determination of diltiazem in biological fluids were based on GCMS or HPLC-UV [4][5][6][7][8]. Few methods have been reported for the simultaneous determination of diltiazem and its metabolites [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a high throughput and robust LC–MS/MS with electrospray ionization method for simultaneous quantitation of diltiazem and its two metabolites in human plasma: Application to a bioequivalence study

Dasandi¹,

Shah²,

Shivprakash³

2009

Journal of Chromatography B

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“…Various analytical methods have been employed for this purpose, e.g. high-performance liquid chromatography in human cardiac tissue [7], in blood [8] and in human plasma [9][10][11][12][13], high-performance thin-layer chromatographic [14], gas chromatography [15], spectrophotometry [16,17], liquidsolid extraction [18] and voltammetry [19]. Since employed techniques for determination of diltiazem in the presence of other drugs are mostly spectroscopy and HPLC, and these methods often are complex and consuming cost solvents, must easy-handled and simple-operating methods need be applied.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric sensor based on Co3O4/SnO2 nanopowders for determination of diltiazem in tablets and biological fluids

et al. 2016

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In this work, an anodic stripping voltammetry for nanomolar determination of diltiazem with a chemically modified carbon paste electrode (CMCPE) containing Co 3 O 4 / SnO 2 nanopowders was studied. The accumulation potential and time were selected at, -0.2 V and 190 s, respectively. The electroanalytical performance of the CMCPE was evaluated regarding the carbon paste composition, the solution pH, the time and potential accumulation, and the potential interferences. The novel electrode showed linear response to diltiazem concentration range of 50-650 nM with a lowest detection limit value of 15 nM. The precisions for six consecutive determinations of 350 and 550 nM diltiazem were 3.2 and 2.5 %, respectively. It was demonstrated that the proposed method was free from most interference. Finally, the method was effectively applied to the determination of diltiazem in pharmaceutical tablets and biological samples.

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Determination of serum diltiazem concentrations in a pharmacokinetic study using gas chromatography with electron capture detection

Cited by 11 publications

References 9 publications

Chiral Cardiovascular Drugs

Chiral Cardiovascular Drugs

Development and validation of a high throughput and robust LC–MS/MS with electrospray ionization method for simultaneous quantitation of diltiazem and its two metabolites in human plasma: Application to a bioequivalence study

Voltammetric sensor based on Co3O4/SnO2 nanopowders for determination of diltiazem in tablets and biological fluids

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