Determination of selected pesticides in fruit juices by matrix solid-phase dispersion and liquid chromatography–tandem mass spectrometry

Radišić, Marina; Grujić, Svetlana; Vasiljević, Tatjana; Laušević, Mila

doi:10.1016/j.foodchem.2008.07.103

Cited by 112 publications

(49 citation statements)

References 22 publications

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“…The non-polar octadecylsilane phase (C 18 ) (Gómez-Pérez et al 2015;Fillatre et al 2014;AguileraLuiz et al 2011;Chung and Lam 2012;Gilbert-Lopez et al 2012;Sinha et al 2012) is commonly used as the stationary phase; the medium-polar octylsilane phase is used much more rarely (C 8 ) (Lozano et al 2012;Nunez et al 2012;Kmellar et al 2011;Ferrer et al 2011). Columns with sorbent particle diameters of 3, 3.5, 4, and 5 μm are available from a range of manufacturers, the most popular being: Zorbax (Rajski et al 2013;Lozano et al 2012;Lee et al 2009a, b;Radisic et al 2009), Atlantis (Tran et al 2012;Tseng et al 2009;Romero-Gonzalez et al 2006), Luna (Camino-Sanchez et al 2010;Lehotay et al 2010), Polaris (Anagnostopoulos et al 2012), and Phenomenex (Fillatre et al 2014). Short columns with the particle diameter not larger than 2 μm, first proposed by Waters in 2004 as BEH C 18 , with the particle diameter of 1.7 μm (Swartz 2005), are gaining increasing popularity.…”

Section: Liquid Chromatographymentioning

confidence: 99%

Liquid Chromatography-Mass Spectrometry in the Analysis of Pesticide Residues in Food

2015

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The analysis of pesticide residues in food is nowadays an increasingly important task. Quality control has to be very strict in order to safeguard the consumers' health. One of the most important goals of food quality assurance is testing food for residues and contaminants. Among chemical hazards, the contamination of food with pesticides has been characterized as a significant source of many serious diseases. Consumption of food containing pesticide residues may cause cancer, malformations, and damage to the endocrine, nervous, and immune system. In order to assure human food safety, The European Community has established maximum residue limits (MRL) of pesticides permitted in products of animal or vegetable origin that are intended for human consumption. In the EU, Regulation (EC) No. 396/2005 of the European Parliament and Council on pesticide residues established the levels of pesticide residues allowed in food and feed. To ensure the compliance of marketed food commodities with the law on food safety, sensitive and reliable analytical methods for the determination of pesticide residues are required. Multiresidue liquid chromatography-mass spectrometry methods (LC-MS) are widely recognized as an ideal, highly specific, and extremely sensitive technique for testing food products. This review discusses LC-MS approaches applied most widely to pesticide residue analysis over the last few years. The main ionization methods and MS detectors used as analytical tools in quantification and/or identification/confirmation of pesticide residues in food are presented.

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Section: Liquid Chromatographymentioning

confidence: 99%

Liquid Chromatography-Mass Spectrometry in the Analysis of Pesticide Residues in Food

2015

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“…1 Thus, determination of pesticide residues in food matrices has become a necessity in view of the toxicity and stability of these xenobiotics. 2 Due to the low detection levels required by the regulatory bodies and the complex nature of the matrices, which the target compounds are present, the trace level detection and identification with prior efficient sample preparation are important aspects in the analytical method. 3 Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the most powerful techniques for the analysis of pesticides in a variety of complex matrices.…”

Section: Introductionmentioning

confidence: 99%

“…It is a streamlined and effective extraction and cleanup approach for the analysis of diverse analyte residues in food matrices. 2 Thus, it was used in this study.…”

Section: Introductionmentioning

confidence: 99%

Determination of Pesticides in Grape Juices by QuEChERS and Liquid Chromatography-Tandem Mass Spectrometry

Souza¹,

Souza²,

Borges³

2016

Journal of the Brazilian Chemical Society

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In this study, we describe a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantifying 25 pesticides in grape juice. This method was optimized and validated according with INMETRO (Instituto Nacional de Metrologia Qualidade e Tecnologia) for the simultaneous determination of pesticide, which are widely used in grape culture in Brazil. The method was based on the QuEChERS (quick, easy, cheap, effective, rugged and safe) methodology. We used AOAC Official Method 2007.01 and Standard Method EN 15662 for sample preparation, both methods presented statistically equivalent recoveries and coefficients of variation. At 0.005 and 2 mg L -1 , fortified blank grape juices had average recoveries of 101 and 112% and average coefficients of variation of 16 and 11%, respectively. The repeatability was tested in three concentrations 0.005, 0.1 and 2 mg L -1 , affording coefficients of variation 16.4, 20.7 and 10.8%, respectively.

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“…Several methods based on supercritical fluid extraction [9, 10], solidphase extraction [11,12], solid-phase microextraction [13], stir bar sorptive extraction [14][15][16] and matrix solid-phase dispersion (MSPD) [1,5,[17][18][19][20][21][22][23] have been developed to overcome the drawbacks caused by using high amounts of glassware and toxic solvents in the classical liquid extraction methods.…”

Section: Introductionmentioning

confidence: 99%

“…MSPD has proven useful as an extraction technique for the determination of pesticide residues in fruits and vegetables by GC [1,4] or LC [18,19]. The MSPD procedure allows the extraction and cleanup of analytes in a single step and is based on the dispersion of the sample on an adsorbent, such as florisil, C18, alumina or silica, followed by eluting with a small amount of solvent [24].…”

Section: Introductionmentioning

confidence: 99%

Matrix effects observed during pesticides residue analysis in fruits by GC

Freitas¹,

Lanças²

2009

J of Separation Science

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The influence of the sample matrix in the GC-electron-capture detection analysis of the pesticides dimethoate, diazinon, chlorothalonil, parathion methyl and fenitrothion in fruits samples has been studied. Experiments have been carried out where the pesticide responses in standard solutions prepared in selected solvent were compared with their response when present in apple, mango, papaya, banana, pineapple and melon extracts. The presence of matrix effects (MEs) and their extent were shown to be simultaneously influenced by several factors (matrix concentration, matrix type, pesticide concentration, analytical range). Pronounced MEs were observed particularly for dimethoate and diazinon in all matrices tested; in lower concentrations, all pesticides presented significant ME. The other pesticides presented variable ME. Higher ME enhancement was detected at lower pesticide concentration levels of and/or at higher matrix concentration solutions. The ME detected for fenitrothion, in the analytical range evaluated, were dependent on matrix type. For each pesticide, solvent and matrix-matched calibrations were compared for all fruit samples, and it could be concluded that quantitation based on standard solutions prepared in blank matrix extract (matrix-matched calibration) should be used to compensate the MEs and to obtain more accurate results for the pesticides studied. IntroductionMost of the pesticide determination in food samples is usually performed using GC in combination with electroncapture detection (ECD) [1,2], nitrogen-phosphorus detection [2,3] or MS detection [4][5][6].Analytical procedures for determination of pesticides in fruit matrices are usually based on an extraction step, using conventional liquid-liquid extraction, followed by a clean-up procedure prior to chromatographic analysis [7,8]. Several methods based on supercritical fluid extraction [9, 10], solidphase extraction [11,12], solid-phase microextraction [13], stir bar sorptive extraction [14][15][16] and matrix solid-phase dispersion (MSPD) [1,5,[17][18][19][20][21][22][23] have been developed to overcome the drawbacks caused by using high amounts of glassware and toxic solvents in the classical liquid extraction methods.MSPD has proven useful as an extraction technique for the determination of pesticide residues in fruits and vegetables by GC [1,4] or LC [18,19]. The MSPD procedure allows the extraction and cleanup of analytes in a single step and is based on the dispersion of the sample on an adsorbent, such as florisil, C18, alumina or silica, followed by eluting with a small amount of solvent [24]. However, in spite of the fact that most of these modern methods provide a simple and rapid procedure for the determination of pesticides in fruits matrices, they do not avoid the presence of co-extracted matrix components that can result in a matrix effect (ME) in the pesticide analysis [25][26][27].MEs are notoriously variable in occurrence and intensity, the GC technique being particularly prone to them [5,28]. The ME is a phenomenon th...

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Determination of selected pesticides in fruit juices by matrix solid-phase dispersion and liquid chromatography–tandem mass spectrometry

Cited by 112 publications

References 22 publications

Liquid Chromatography-Mass Spectrometry in the Analysis of Pesticide Residues in Food

Liquid Chromatography-Mass Spectrometry in the Analysis of Pesticide Residues in Food

Determination of Pesticides in Grape Juices by QuEChERS and Liquid Chromatography-Tandem Mass Spectrometry

Matrix effects observed during pesticides residue analysis in fruits by GC

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