Determination of selected perfluorinated alkyl acids and persistent organic pollutants from a small volume human serum sample relevant for epidemiological studies

Predictors of Beta-Hexachlorocyclohexane blood levels among people living close to a chemical plant and an illegal dumping site

“…The blood was processed for the separation of serum and stored at the laboratory of the Department of Prevention in Colleferro at − 20°C, until the shipment to the National Institute for Health and Welfare, Department of Health Security, in Kuopio, Finland, which conducted the measurement of β-HCH. The method used for the analysis has been described previously in detail [17]. In brief, the method consisted of protein precipitation with ethanol, extraction of β-HCH with dichloromethanehexane, cleanup with multilayer silica column and analysis with Agilent 7000C gas chromatographytriple quadrupole mass spectrometry (GC-MS/MS) instrument.…”

Children's exposure to perfluoroalkyl acids – a modelling approach

“…57 However, this problem was addressed by analysing the children's serum samples at a slightly different transition mass. 58 In summary, to assess the exposure to PFHxS accurately, future research efforts should focus on potentially missing exposure pathways to PFHxS and its precursors and the derivation of pharmacokinetic parameters specically for this compound, as they are currently not documented.…”

Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort

“…Chemical analyses of POP concentrations POP concentrations were measured in 200 µL plasma samples from the same blood collection sample obtained at study entry in which lipids were measured (Riboli et al, 2002). Analyses were performed at THL (Koponen et al, 2013). Twenty-two POPs were measured: three polybrominated diphenyl ethers (PBDEs 47, 99, 153), eight non-dioxin like polychlorinated biphenyls (PCB congeners 74,99,138,153,170,180,183,and 187), two dioxin like PCBs (congeners 118 and 156), and nine organochlorine pesticides or their metabolites:…”

“…The THL laboratory participates three times a year in AMAP interlaboratory comparisons (Ring Test for Persistent Organic Pollutants in human serum, National Institute of Public Health, Quebec, Canada) (Koponen et al, 2013;Krauskopf et al, 2017;Vafeiadi et al, 2017). POP concentrations were individually converted to lipid-based concentrations (i.e., corrected or normalized for TL) by dividing the crude plasma POP concentration by TL (see 'Lipid concentrations' above).…”