Determination of selected antiretroviral drugs in wastewater, surface water and aquatic plants using hollow fibre liquid phase microextraction and liquid chromatography - tandem mass spectrometry

Mlunguza, Nomchenge Yamkelani; Ncube, Somandla; Mahlambi, Precious; Chimuka, Luke; Madikizela, Lawrence Mzukisi

doi:10.1016/j.jhazmat.2019.121067

Cited by 62 publications

(38 citation statements)

References 43 publications

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“…The drug residue and metabolite are discharged into the environment through sewage leading to spikes of antiviral drugs in wastewater and ambient waters ( Race et al, 2020 , Funke et al, 2016 , Khetan and Collins, 2007 ). In addition, studies confirmed incomplete removal of antiviral drugs in wastewater treatment plants (WWTPs) ( Nannou et al, 2020 , Mlunguza et al, 2020 , Ngumba et al, 2020 ). The unprecedented use of antiviral drug during pandemic events, has led to the development of antiviral-drug resistant viruses within wild animal reservoir and may compromise the treatment of COVID-19 patients ( Ahmed et al, 2020 , Musharrafieh et al, 2020 ).…”

Section: Introductionmentioning

confidence: 98%

A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance

Kumar

Mazumder

Mohapatra

et al. 2021

Journal of Hazardous Materials

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In this review, we present the environmental perspectives of the viruses and antiviral drugs related to SARS-CoV-2. The present review paper discusses occurrence, fate, transport, susceptibility, and inactivation mechanisms of viruses in the environment as well as environmental occurrence and fate of antiviral drugs, and prospects (prevalence and occurrence) of antiviral drug resistance (both antiviral drug resistant viruses and antiviral resistance in the human). During winter, the number of viral disease cases and environmental occurrence of antiviral drug surge due to various biotic and abiotic factors such as transmission pathways, human behaviour, susceptibility, and immunity as well as cold climatic conditions. Adsorption and persistence critically determine the fate and transport of viruses in the environment. Inactivation and disinfection of virus include UV, alcohol, chemical-base methods but the susceptibility of virus against these methods varies. Wastewater treatment plants (WWTPs) are major sources of antiviral drugs and their metabolites and transformation products. Ecotoxicity of antiviral drug residues against aquatic organisms have been reported, however more threatening is the development of antiviral resistance, both in humans and in wild animal reservoirs. In particular, emergence of antiviral drug-resistant viruses via exposure of wild animals to high loads of antiviral residues during the current pandemic needs further evaluation.

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Section: Introductionmentioning

confidence: 98%

A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance

Kumar

Mazumder

Mohapatra

et al. 2021

Journal of Hazardous Materials

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“…As a result, millions of people have access to these drugs on a daily basis, with more than 40 different antiretroviral drugs being used for the treatment of HIV. These include abacavir, efavirenz, lamivudine, nevirapine, tenofovir, and zidovudine; many of which are used in combination ( Russo et al, 2018 ; Mlunguza et al, 2020 ). As a consequence of the increase in the rate of HIV infection over the years, there has been a significant increase in the production and consumption of antiretroviral drugs worldwide ( Nannou et al, 2020 ; Reddy et al, 2021 ).…”

Section: Common Pharmaceuticals Detected In Water (Surface and Ground...mentioning

confidence: 99%

Pharmaceutical Pollution in Aquatic Environments: A Concise Review of Environmental Impacts and Bioremediation Systems

et al. 2022

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The presence of emerging contaminants in the environment, such as pharmaceuticals, is a growing global concern. The excessive use of medication globally, together with the recalcitrance of pharmaceuticals in traditional wastewater treatment systems, has caused these compounds to present a severe environmental problem. In recent years, the increase in their availability, access and use of drugs has caused concentrations in water bodies to rise substantially. Considered as emerging contaminants, pharmaceuticals represent a challenge in the field of environmental remediation; therefore, alternative add-on systems for traditional wastewater treatment plants are continuously being developed to mitigate their impact and reduce their effects on the environment and human health. In this review, we describe the current status and impact of pharmaceutical compounds as emerging contaminants, focusing on their presence in water bodies, and analyzing the development of bioremediation systems, especially mycoremediation, for the removal of these pharmaceutical compounds with a special focus on fungal technologies.

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“…The transport of AVDs and their residues into the existing pharmaceutically-sick ecosystems further exacerbate the toxicological threats to human and environmental ecosystems ( Rambabu et al, 2020 ). Previous studies demonstrated the inefficient removal of AVDs by conventional activated sludge processes mostly consisting of the physical and biological systems, which leaves AVDs and their metabolites in effluents ( Funke et al, 2016 , Mlunguza et al, 2020 , Wang et al, 2021 ). The inclusion of tertiary treatments in WWTPs could further remove AVDs to certain extents but increase operational costs, limiting their use in practice ( Qiu et al, 2021a ).…”

Section: Introductionmentioning

confidence: 99%

Unravelling multiple removal pathways of oseltamivir in wastewater by microalgae through experimentation and computation

Zeeshan

Qiu

et al. 2022

Journal of Hazardous Materials

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Increased worldwide consumption of antiviral drugs (AVDs) amid COVID-19 has induced enormous burdens to the existing wastewater treatment systems. Microalgae-based bioremediation is a competitive alternative technology due to its simultaneous nutrient recovery and sustainable biomass production. However, knowledge about the fate, distribution, and interaction of AVDs with microalgae is yet to be determined. In this study, a concentration-determined influence of AVD oseltamivir (OT) was observed on the biochemical pathway of Chlorella sorkiniana (C.S-N1) in synthetic municipal wastewater. The results showed that high OT concentration inhibited the biomass growth through increased oxidative stress, and restrained photosynthesis. Nevertheless, complete OT removal was achieved at its optimized concentration of 10 mg/L by various biotic (82%) and abiotic processes (18.0%). The chemical alterations in three subtypes of extracellular polymeric substances (EPS) were primarily investigated by electrostatic (OT +8.22 mV vs. C.S-N1 -18.31 mV) and hydrophobic interactions between EPS-OT complexes supported by secondary structure protein analysis. Besides, six biodegradation-catalyzed transformation products were identified by quadrupole-time-of-flight mass spectrometer and by density functional theory. Moreover, all the TPs exhibited log Kow ≤ 5 and bioconcentration factor values of < 5000 L/kg, meeting the practical demands of environmental sustainability. This study broadens our understanding of microalgal bioadsorption and biodegradation, promoting microalgae bioremediation for nutrient recovery and AVDs removal.

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Determination of selected antiretroviral drugs in wastewater, surface water and aquatic plants using hollow fibre liquid phase microextraction and liquid chromatography - tandem mass spectrometry

Cited by 62 publications

References 43 publications

A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance

A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance

Pharmaceutical Pollution in Aquatic Environments: A Concise Review of Environmental Impacts and Bioremediation Systems

Unravelling multiple removal pathways of oseltamivir in wastewater by microalgae through experimentation and computation

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