Determination of RS,E/Z-tocotrienols by HPLC

Drotleff, Astrid M.; Ternes, Waldemar

doi:10.1016/s0021-9673(00)01110-9

Cited by 40 publications

(32 citation statements)

References 16 publications

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“…Structurally, tocopherols and tocotrienols are very similar. The main difference is that tocopherols have a long saturated carbon side chain with chiral centers, while tocotrienols have three unsaturated bonds in the carbon side chain with one chiral center 39 . This unique property promotes the efficient metabolic function of tocotrienols, which allows tocotrienols to penetrate tissues with saturated fatty layers more readily when compared with tocopherols.…”

Section: Tocotrienolsmentioning

confidence: 99%

Tocotrienol research: past into present

Wong

Radhakrishnan

2012

Nutrition Reviews

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The vitamin E family consists of eight isomers known as alpha-, beta-, gamma-, and delta-tocopherols and alpha-, beta-, gamma-, and delta-tocotrienols. Numerous studies focused on the health benefits of these isomers have been performed since the discovery of vitamin E in 1922. Recent discoveries on the potential therapeutic applications of tocotrienols have revolutionized vitamin E research. Nevertheless, despite the abundance of literature, only 1% of vitamin E research has been conducted on tocotrienols. Many new advances suggest that the use of tocotrienols for health improvement or therapeutic purposes is promising. Although the mechanisms of action of tocotrienols in certain disease conditions have been explored, more detailed investigations into the fundamentals of the health-promoting effects of these molecules must be elucidated before they can be recommended for health improvement or for the treatment or prevention of disease. Furthermore, many of the studies on the effects of tocotrienols have been carried out using cell lines and animal models. The effects in humans must be well established before tocotrienols are used as therapeutic agents in various disease conditions, hence the need for more evidence-based human clinical trials.

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Section: Tocotrienolsmentioning

confidence: 99%

Tocotrienol research: past into present

Wong

Radhakrishnan

2012

Nutrition Reviews

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“…Analysis of stereoisomer ratios of a-tocopherol from feedstuffs and muscle Total a-tocopherol from feedstuffs (three samples each of grass and silage; four samples of concentrate) and muscle (four samples from each of the P, SiP, SiPC and C groups and four samples from each country) was extracted and separated as described above and collected using an Agilent fraction collector (Agilent Technologies, 1200 series, Analyt FC). a-Tocopherol was derivatised following modifications of the method of Riss et al (1994) by Drotleff and Ternes (2001). The a-tocopherol fractions in n-hexane were transferred to 2 ml Eppendorf tubes and evaporated to dryness under nitrogen.…”

Section: Measurement Of A-tocopherol In Feed and Musclementioning

confidence: 99%

α-Tocopherol stereoisomers in beef as an indicator of vitamin E supplementation in cattle diets

et al. 2011

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“…It is also possible to separate simultaneously the four tocopherols into their 2R and 2S isomers using a simple isocratic method (hexane plus 0.05% ethanol or propanol) by HPLC on a Chiralcel OD-H column. The same column was also used in the determination of tocotrienols stereoisomers [136]. Stereochemistry of natriuretic factor ␥-CEHC was assessed by chiral HPLC on a S,S Whelk O 1 column [137] while simultaneous separation of ␣-and ␥-CEHC enantiomers was accomplished on a Chiradex column in a study regarding the change of CEHCs serum levels after a single dose of vitamin E supplement [138].…”

Section: Chiral Chromatography Of Vitamin E Moleculesmentioning

confidence: 99%