Determination of Rosuvastatin in Pharmaceutical Formulations by Capillary Zone Electrophoresis

Süslü, İncilay; Çelebi̇er, Mustafa; Altınöz, Sacide

doi:10.1365/s10337-007-0221-y

Cited by 21 publications

(9 citation statements)

References 28 publications

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“…Despite the wide application of rosuvastatin in the treatment of hyperlipidemia, a literature survey reveals that only few methods have been reported for the determination of rosuvastatin calcium in pharmaceutical formulations and biological samples including high-performance liquid chromatography (HPLC), [4][5][6][7][8] spectrophotometry, [9] capillary electrophoresis, [10] and chemometry. [11] An ideal stability-indicating method is one that quantifies the standard drug alone and also resolves its degradates.…”

Section: Introductionmentioning

confidence: 99%

Selective Chromatographic Methods for the Determination of Rosuvastatin Calcium in the Presence of Its Acid Degradation Products

Mostafa

Badawey

Lamie

et al. 2014

Journal of Liquid Chromatography & Related Technologies

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& Two accurate and sensitive stability-indicating methods for the determination of rosuvastatin calcium in the presence of its acid degradation products are presented. The first method utilizes quantitative spectrodensitometric evaluation thin-layer chromatography (TLC) of rosuvastatin calcium in the presence of its acid degradation products, using ethyl acetate=methanol=ammonia (7:3:0.01, by volume) as a mobile phase. Chromatograms are scanned at 245 nm. This method analyzes rosuvastatin calcium in a concentration range of 0.6-3.4 lg=band with mean percentage recovery of 99.78 AE 1.42. The second method is a high-performance liquid chromatography (HPLC) method for the simultaneous determination of rosuvastatin calcium in the presence of its acid degradation products. The mobile phase consists of water=acetonitrile=methanol (40:40:20, by volume). The standard curve of rosuvastatin calcium shows a good linearity over a concentration range of 10-60 lg mL À1 with mean percentage recovery of 100.22 AE 0.86. These methods were successfully applied to the determination of rosuvastatin calcium in bulk powder, laboratory-prepared mixtures containing different percentages of the acid degradation products, and pharmaceutical dosage forms. The validity of results was assessed by applying standard addition technique. The results obtained were found to agree statistically with those obtained by a reported method, showing no significant difference with respect to accuracy and precision.

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Section: Introductionmentioning

confidence: 99%

Selective Chromatographic Methods for the Determination of Rosuvastatin Calcium in the Presence of Its Acid Degradation Products

Mostafa

Badawey

Lamie

et al. 2014

Journal of Liquid Chromatography & Related Technologies

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“…Proposed method a (found (mg)) Compared method b [15] x: mean ± standard error; R.S.D.%: relative standard deviation. tion was checked and ZAF solution was found to be unchanged within this period.…”

Section: Stabilitymentioning

confidence: 99%

“…The obtained percentage recoveries and the relative standard deviations based on the average of 7 replicate measurements were found and the results are presented in Table 7. The obtained results were compared to those obtained by a reported HPLC method [15]. The statistical comparison of methods was done by Wilcoxon Paired Test (t c = 7.50 > t t = 2.00, p > 0.05).…”

Section: Analysis Of Accolate ® Tabletsmentioning

confidence: 99%

“…In the another HPLC method described, ZAF was extracted from deproteinated plasma samples using solid phase extraction columns and analyzed by normal phase liquid chromatography with fluorescence detection [14]. The other HPLC method with UV detection has been used for the determination of ZAF in pharmaceutical formulation [15]. Three voltammetric methods, such as squarewave voltammetry (OSWV), square-wave adsorptive stripping voltammetry (OSWAdSV) and differential adsorptive stripping voltammetry (DPAdSV) methods used for the direct determination of ZAF in its bulk form and pharmaceutical formulations [16,17].…”

Section: Introductionmentioning

confidence: 99%

“…The developed and validated method was applied to the determination of ZAF in pharmaceutical formulation. The results obtained by the developed method were compared with the HPLC method in the literature [15].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Optimisation, validation and application of a capillary electrophoretic method for the determination of zafirlukast in pharmaceutical formulations

Süslü¹,

Demircan²,

Altınöz³

et al. 2007

Journal of Pharmaceutical and Biomedical Analysis

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Micellar electrokinetic chromatographic determination of rosuvastatin in rabbit plasma and evaluation of its pharmacokinetics and interaction with niacin

El-Kommos

Mohamed

Ali

et al. 2014

Biomedical Chromatography

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A specific, accurate, precise and reproducible micellar electrokinetic chromatographic method was developed for in vitro and in vivo estimation of rosuvastatin, a synthetic and potent HMG-CoA inhibitor, in rabbit plasma. Further, its pharmacokinetics in the presence of niacin, which could be co-administered for monitoring of severe hypercholestremia, was investigated. The assay procedures involved simple liquid-liquid extraction of rosuvastatin and internal standard, atorvastatin, from a small plasma volume directly into acetonitrile. The organic layer was separated and evaporated under a gentle stream of nitrogen. The residue was reconstituted in the mobile phase and injected electrokinetically into electropherosis system. The background electrolyte consisted of borate buffer (25.0 mm, pH 9.5), 10.0% organic modifier (5.0% methanol + 5.0% acetonitrile) and 25.0 mm sodium dodecyl sulfate at 20.0 kV applied voltage and 215.0 nm detection wavelength for the effective separation of rosuvastatin, niacin and atorvastatin.

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Determination of Rosuvastatin in Pharmaceutical Formulations by Capillary Zone Electrophoresis

Cited by 21 publications

References 28 publications

Selective Chromatographic Methods for the Determination of Rosuvastatin Calcium in the Presence of Its Acid Degradation Products

Selective Chromatographic Methods for the Determination of Rosuvastatin Calcium in the Presence of Its Acid Degradation Products

Optimisation, validation and application of a capillary electrophoretic method for the determination of zafirlukast in pharmaceutical formulations

Micellar electrokinetic chromatographic determination of rosuvastatin in rabbit plasma and evaluation of its pharmacokinetics and interaction with niacin

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