Determination of rosuvastatin calcium in its bulk drug and pharmaceutical preparations by high-performance thin-layer chromatography

Sane, R. T.; Kamat, Sudhir S.; Menon, S. N.; Inamdar, Shafi; Mote, Mandar

doi:10.1556/jpc.18.2005.3.4

Cited by 25 publications

(17 citation statements)

References 2 publications

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“…Not so commonly used in quality control analysis of pharmaceuticals, HPTLC method was proposed [58] for determination of rosuvastatin in its bulk drug and pharmaceutical preparations. Analysis was performed in a Camag twin-trough chamber on silica gel 60F(254) HPTLC plates.…”

Section: Rosuvastatinmentioning

confidence: 99%

A Review of Current Trends and Advances in Analytical Methods for Determination of Statins: Chromatography and Capillary Electrophoresis

Nigović¹,

Mornar²,

Sertić³

2012

Chromatography - The Most Versatile Method of Chemical Analysis

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Section: Rosuvastatinmentioning

confidence: 99%

A Review of Current Trends and Advances in Analytical Methods for Determination of Statins: Chromatography and Capillary Electrophoresis

Nigović¹,

Mornar²,

Sertić³

2012

Chromatography - The Most Versatile Method of Chemical Analysis

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“…Despite the wide application of rosuvastatin in the treatment of hyperlipidemia, a literature survey reveals that only few methods have been reported for the determination of rosuvastatin calcium in pharmaceutical formulations and biological samples including high-performance liquid chromatography (HPLC), [4][5][6][7][8] spectrophotometry, [9] capillary electrophoresis, [10] and chemometry. [11] An ideal stability-indicating method is one that quantifies the standard drug alone and also resolves its degradates.…”

Section: Introductionmentioning

confidence: 99%

Selective Chromatographic Methods for the Determination of Rosuvastatin Calcium in the Presence of Its Acid Degradation Products

Mostafa

Badawey

Lamie

et al. 2014

Journal of Liquid Chromatography & Related Technologies

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& Two accurate and sensitive stability-indicating methods for the determination of rosuvastatin calcium in the presence of its acid degradation products are presented. The first method utilizes quantitative spectrodensitometric evaluation thin-layer chromatography (TLC) of rosuvastatin calcium in the presence of its acid degradation products, using ethyl acetate=methanol=ammonia (7:3:0.01, by volume) as a mobile phase. Chromatograms are scanned at 245 nm. This method analyzes rosuvastatin calcium in a concentration range of 0.6-3.4 lg=band with mean percentage recovery of 99.78 AE 1.42. The second method is a high-performance liquid chromatography (HPLC) method for the simultaneous determination of rosuvastatin calcium in the presence of its acid degradation products. The mobile phase consists of water=acetonitrile=methanol (40:40:20, by volume). The standard curve of rosuvastatin calcium shows a good linearity over a concentration range of 10-60 lg mL À1 with mean percentage recovery of 100.22 AE 0.86. These methods were successfully applied to the determination of rosuvastatin calcium in bulk powder, laboratory-prepared mixtures containing different percentages of the acid degradation products, and pharmaceutical dosage forms. The validity of results was assessed by applying standard addition technique. The results obtained were found to agree statistically with those obtained by a reported method, showing no significant difference with respect to accuracy and precision.

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“…Also, it was analyzed by different chromatographic methods such as HPTLC [11][12][13], HPLC [14][15][16][17], UPLC [18,19], and LC-MS/MS methods [20,21]. Rosuvastatin calcium was determined either alone or in its different combined dosage forms by several methods including titrimetric [22], different spectrophotometric [23][24][25][26][27][28][29], spectrofluorimetric [30], HPTLC [31][32][33][34] and HPLC [35][36][37][38] methods.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of bisoprolol fumarate and rosuvastatin calcium in a new combined formulation by validated RP-HPLC

et al. 2019

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A simple, specific, and precise RP-HPLC method was developed and validated for simultaneous determination of Bisoprolol fumarate (BIS) and Rosuvastatin calcium (ROS) in new formulated tablets. The developed RP-HPLC method depended on chromatographic separation using C18 column (150×4.6 mm, 0.5 μm) with mobile phase consisted of acetonitrile and 0.05 aqueous solution of orthophosphoric acid at the ratio of 65:35 % (v:v) with a flow rate of 1 mL/min and UV detection was carried out at 230 nm. Factors affecting the developed methods were studied and optimized and the retention times for BIS and ROS were found to be 2.758 and 4.974 min, respectively. Linearity of the proposed method was observed over a concentration range 0.2-50 μg/mL for each of BIS (r = 0.9999) and ROS (r = 0.9998). The proposed method was successfully applied for the determination of the studied drugs in their bulk powder, laboratory prepared mixtures and in the formulated tablets. The developed method is the first chromatographic method for determination of those drugs and showed no significant difference when compared with the reported methods.

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Determination of rosuvastatin calcium in its bulk drug and pharmaceutical preparations by high-performance thin-layer chromatography

Cited by 25 publications

References 2 publications

A Review of Current Trends and Advances in Analytical Methods for Determination of Statins: Chromatography and Capillary Electrophoresis

A Review of Current Trends and Advances in Analytical Methods for Determination of Statins: Chromatography and Capillary Electrophoresis

Selective Chromatographic Methods for the Determination of Rosuvastatin Calcium in the Presence of Its Acid Degradation Products

Simultaneous determination of bisoprolol fumarate and rosuvastatin calcium in a new combined formulation by validated RP-HPLC

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