Determination of rifampin in human plasma by high-performance liquid chromatography with ultraviolet detection

Lau, Yau Yi; Hanson, Glenn D.; Carel, Barbara J.

doi:10.1016/0378-4347(95)00424-6

Cited by 22 publications

(11 citation statements)

References 9 publications

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“…The overall precision and accuracy measurements, expressed as percent coefficient of variation and as percent mean deviation, were Յ15%, in terms of absolute values. The lower limit of quantification was 0.1 g/ml for 400 l of rabbit plasma (3,21,22).…”

Section: Methodsmentioning

confidence: 99%

Addition of Gentamicin or Rifampin Does Not Enhance the Effectiveness of Daptomycin in Treatment of Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus

Miró

García-de-la-Mària

Armero

et al. 2009

Antimicrob Agents Chemother

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[20%]; P ‫؍‬ 0.01 and P ‫؍‬ 0.02, respectively). No statistical difference was noted between daptomycin plus gentamicin and daptomycin alone for MRSA treatment. In the combination arm, all isolates from vegetations remained susceptible to daptomycin, gentamicin, and rifampin. Sixty-one percent of the isolates (8/13) acquired resistance to rifampin during monotherapy. In the daptomycin arm, resistance was detected in only one case, in which the daptomycin MIC rose to 2 g/ml among the recovered bacteria. In conclusion, the addition of gentamicin or rifampin does not enhance the effectiveness of daptomycin in the treatment of experimental endocarditis due to MRSA.

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Section: Methodsmentioning

confidence: 99%

Addition of Gentamicin or Rifampin Does Not Enhance the Effectiveness of Daptomycin in Treatment of Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus

Miró

García-de-la-Mària

Armero

et al. 2009

Antimicrob Agents Chemother

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“…There is a general agreement that this type of stability should be evaluated to find out if preservatives have to be added to prevent degradation of analyte during sample preparation. [25–27]…”

Section: Validation Parametersmentioning

confidence: 99%

Bioanalytical method validation: An updated review

Tiwari¹,

Tiwari²

2010

Pharm Methods

179

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The development of sound bioanalytical method(s) is of paramount importance during the process of drug discovery and development, culminating in a marketing approval. The objective of this paper is to review the sample preparation of drug in biological matrix and to provide practical approaches for determining selectivity, specificity, limit of detection, lower limit of quantitation, linearity, range, accuracy, precision, recovery, stability, ruggedness, and robustness of liquid chromatographic methods to support pharmacokinetic (PK), toxicokinetic, bioavailability, and bioequivalence studies. Bioanalysis, employed for the quantitative determination of drugs and their metabolites in biological fluids, plays a significant role in the evaluation and interpretation of bioequivalence, PK, and toxicokinetic studies. Selective and sensitive analytical methods for quantitative evaluation of drugs and their metabolites are critical for the successful conduct of pre-clinical and/or biopharmaceutics and clinical pharmacology studies.

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“…In vivo drug disposition study [22][23][24][25] Healthy Wistar rats between 2 and 3 months of age, and weighing 150-200 g were used for the study. Group 5 received RAM formulation without βCD (Instilled intratracheally) and Group 6 received RAM formulation without βCD (Orally).…”

Section: In Vitro Drug Release Studymentioning

confidence: 99%

Formulation and Evaluation of Novel Spray-dried Alginate Microspheres as Pulmonary Delivery Systems of Rifampicin in Rats

S¹,

Devi²,

Suresh³

2015

IJPER

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Background: Lung administration of anti-biotics in the dry powder form is promising for improved treatment efficiency for pulmonary infections, as it increases drug concentration at sites of infection while minimizing systemic side effects. For poorly soluble molecules like rifampicin, an anti-tubercular drug encapsulated in particulate system in presence of β-cyclodextrin may improve lung delivery. Materials and Methods: Present study was aimed to evaluate the pharmacokinetic parameters of rifampicin loaded alginate spraydried microparticles administered by pulmonary route. Novel spray-dried sodium alginate microspheres were formulated with β-cyclodextrin to form bioadhesive microparticles for sustained release of rifampicin. The particles without β-cyclodextrin and without drug were also prepared. Intratracheal instillation was adopted for lung delivery in comparison with oral delivery of pure drug. Results: Around 75% microspheres were in the respirable range, with satisfied aerodynamic characteristics. Aqueous solubility and skin permeation of rifampicin were increased significantly in presence of β-cyclodextrin. The in vitro antimycobacterial activity of the formulation showed enhanced activity in presence of β-cyclodextrin. The relative bioavailability of rifampicin alginate microspheres administered by pulmonary route was significantly higher when compared to that of oral route indicating the therapeutic potential of microspheres as a promising alternative to the presently available oral route. Conclusion: Along with sustained release of drug from the particulate formulation, the presence of cyclodextrin has the potential to achieve higher therapeutic efficacy by increasing the solubility and permeation of rifampicin.

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Determination of rifampin in human plasma by high-performance liquid chromatography with ultraviolet detection

Cited by 22 publications

References 9 publications

Addition of Gentamicin or Rifampin Does Not Enhance the Effectiveness of Daptomycin in Treatment of Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus

Addition of Gentamicin or Rifampin Does Not Enhance the Effectiveness of Daptomycin in Treatment of Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus

Bioanalytical method validation: An updated review

Formulation and Evaluation of Novel Spray-dried Alginate Microspheres as Pulmonary Delivery Systems of Rifampicin in Rats

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