Determination of residual solvents in docetaxel by headspace gas chromatography

Siddiqui, Masoom Raza; Singh, Ravi P.; Bhatnagar, Anuj; Kumar, Jitendra; Chaudhary, Manu

doi:10.1016/j.arabjc.2013.09.014

Cited by 7 publications

(2 citation statements)

References 9 publications

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“…A simple and sensitive gas chromatographic method has been developed and validated for detection of residual organic solvents [ 15 ]. The conditions for detecting the residual organic solvents were set as follows: chromatographic column type, DB-624 capillary column; sample inlet and detector temperatures, 200°C and 250°C, respectively.…”

Section: Methodsmentioning

confidence: 99%

Primary biocompatibility tests of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) core–shell nanocarriers

et al. 2018

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Layer-by-layer (LbL) self-assembly is the technology used in intermolecular static electricity, hydrogen bonds, covalent bonds and other polymer interactions during film assembling. This technology has been widely studied in the drug carrier field. Given their use in drug delivery systems, the biocompatibility of these potential compounds should be addressed. In this work, the primary biocompatibility of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) [PLGA-(PLO/fucoidan)] core–shell nanoparticles (NPs) was investigated. Atomic force microscopy revealed the PLGA-(PLO/Fucoidan)4 NPs to be spherical, with a uniform size distribution and a smooth surface, and the NPs were stable in physiological saline. The residual amount of methylene chloride was further determined by headspace gas chromatography, in which the organic solvent can be volatilized during preparation. Furthermore, cell viability, acridine orange/ethidium bromide staining, haemolysis and mouse systemic toxicity were all assessed to show that PLGA-(PLO/fucoidan)4 NPs were biocompatible with cells and mice. Therefore, these NPs are expected to have potential applications in future drug delivery systems.

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Section: Methodsmentioning

confidence: 99%

Primary biocompatibility tests of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) core–shell nanocarriers

et al. 2018

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“…The international conference on harmonization (ICH) has limited the amount of residual solvent in their guidelines and has classified it as I, II and III according to the toxicity level and environmental hazard [4]. In our opinion the best technique to determine the residual solvent in bulk as well as in formulation is gas chromatography combined with static headspace (HSGC), as it has the ability to separate solvents with great accuracy and with very low detection limit [5][6][7][8][9][10][11]. The supplier claims dimethylacetamide, methanol, benzene for metformin hydrochloride and methanol, methyl isobutyl ketone for hydrochlorothiazide are present in the final product.…”

Section: Introductionmentioning

confidence: 99%

Headspace Gas Chromatography for the Determination of Residual Solvents in Metformin Hydrochloride and Hydrochlorothiazide

Haque¹,

Umar²,

H³

et al. 2021

Yanbu Journal of Engineering and Science

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An accurate analytical method was developed using headspace gas chromatography for the determination of residual solvents in metformin hydrochloride and hydrochlorothiazide. The residual solvent was studied with the help of gas chromatography (Shimadzu 2014 model) combined with Teledyne Tekmar headspace and GC solution software. The residual solvents were separated using DB-WAX column 30-meter-long, 0.32mm internal diameter for metformin hydrochloride and BP624 column 30-meter-long, 0.53 mm internal diameter for hydrochlorothiazide. The limit of detection and limit of quantitation of dimethylacetamide, methanol and benzene were 17.00, 10.93, 0.18 and 51.92, 33.13, 0.57 ppm respectively for metformin hydrochloride and in case of hydrochlorothiazide, the values were 3.40& 1.30 ppm and 10.15 & 4.00 ppm for methanol and methyl isobutyl ketone respectively. The method was validated according to international conference on harmonization guideline in terms of specificity, linearity, precision, accuracy and robustness.

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Determination of Pyridine as a Decomposition Product in Ceftazidime and Mouthwash Solution

et al. 2017

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Determination of residual solvents in docetaxel by headspace gas chromatography

Cited by 7 publications

References 9 publications

Primary biocompatibility tests of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) core–shell nanocarriers

Primary biocompatibility tests of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) core–shell nanocarriers

Headspace Gas Chromatography for the Determination of Residual Solvents in Metformin Hydrochloride and Hydrochlorothiazide

Determination of Pyridine as a Decomposition Product in Ceftazidime and Mouthwash Solution

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