Determination of quinolones in water samples by solid-phase extraction and liquid chromatography with fluorimetric detection

Prat, M.D.; Benito, Juana Gómez; Compañó, R.; Hernández-Arteseros, J. A.; Granados, Mercè

doi:10.1016/j.chroma.2004.04.042

Cited by 68 publications

(34 citation statements)

References 20 publications

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“…LC-MS/MS is indicated as the technique of choice to assay relatively polar pharmaceuticals and their metabolites as it is especially suitable for the environmental analysis because of its selectivity comparing to UV [11,36] or FD [50,53,57].…”

Section: Methodsmentioning

confidence: 99%

“…At basic conditions, the anionic species of both acidic and piperazinylic quinolones are less retained in comparison to cationic, zwitterionic and neutral species on the polymeric Oasis HBL column, but they may be retained on SAX cartridge. However, the different behaviour between both groups is observed at acidic pH [11,50]. The behaviour of Qs during SPE extraction was studied [36].…”

Section: Quinolone Antibioticsmentioning

confidence: 99%

“…The best pH value to assure that FQs are in cationic form should be two units below the pK a constants. Only in one study, pH of water sample was adjusted pH 5.5 [50].…”

Section: Quinolone Antibioticsmentioning

confidence: 99%

“…The mostly used SPE cartridges were polymeric Oasis HBL [50,53,54]. However, other types including cation-exchange [51,52], C 18 [36] and Chromabond tetracycline [55] were used.…”

Section: Quinolone Antibioticsmentioning

confidence: 99%

“…LC coupled to tandem MS method is nowadays a technique of choice for the determination of very low concentrations of FQs in environmental waters because of its selectivity and specificity. However, LC with FD was used in six works [50][51][52][53][54][55]. FQs are naturally highly fluorescent compounds and RP-LC-FD can be used for their determination.…”

Section: Fluoroquinolone Antibioticsmentioning

confidence: 99%

See 4 more Smart Citations

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Seifrtová¹,

Nováková²,

Lino³

et al. 2009

Analytica Chimica Acta

296

167

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a b s t r a c tThe widespread occurrence of antibiotics as contaminants in the aquatic environment has increased attention in the last years. The concern over the release of antibiotics into the environment is related primarily to the potential for the development of antimicrobial resistance among microorganisms. This article presents an overview of analytical methodologies for the determination of quinolone (Qs) and fluoroquinolone (FQs), macrolide (MLs), tetracycline (TCs), sulfonamide (SAs) antibiotics and trimethoprim (TMP) in different environmental waters. The analysis of these antibiotics has usually been carried out by high-performance liquid chromatography (HPLC) coupled to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) and to a lesser extent by ultraviolet (UV) or fluorescence detection (FD). A very important step before LC analysis is sample preparation and extraction leading to elimination of interferences and prevention of matrix effect and preconcentration of target analytes.

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Section: Methodsmentioning

confidence: 99%

Section: Quinolone Antibioticsmentioning

confidence: 99%

“…The best pH value to assure that FQs are in cationic form should be two units below the pK a constants. Only in one study, pH of water sample was adjusted pH 5.5 [50].…”

Section: Quinolone Antibioticsmentioning

confidence: 99%

“…The mostly used SPE cartridges were polymeric Oasis HBL [50,53,54]. However, other types including cation-exchange [51,52], C 18 [36] and Chromabond tetracycline [55] were used.…”

Section: Quinolone Antibioticsmentioning

confidence: 99%

Section: Fluoroquinolone Antibioticsmentioning

confidence: 99%

See 3 more Smart Citations

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Seifrtová¹,

Nováková²,

Lino³

et al. 2009

Analytica Chimica Acta

296

167

View full text Add to dashboard Cite

show abstract

Voltammetric Determination of Marbofloxacin at Carbon Paste Sensor Integrated with Copper Oxide Nanoparticles

2022

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The present work introduced copper oxide nanoparticles as an efficient electrode modifier for sensitive adsorptive differential pulse voltammetric assaying of marbofloxacin (MRB) in pharmaceutical formulations and surface water samples. In the presence of sodium dodecyl sulphate (SDS) at pH 4.0, the marbofloxacin molecule was irreversibly oxidized at the electrode surface showing an anodic oxidation peak at 0.954 V. The electrode reaction mechanism was assumed as adsorption‐reaction controlled accompanied by the transferring of two electrons and proton exchange in agreement with the molecular orbital calculations performed on MRB molecule suggesting the oxidation of the amino group in the piperazinyl ring. At the optimized measuring conditions, the recorded peak heights were linearly correlated with the MRB concentration within the range from 6.67 to 360 ng mL−1, and the estimated LOD value was 2.2 ng mL−1. The integrated sensor showed a prolonged operational lifetime with good reproducibility of measurements. Based on the selectivity and sensitivity of the proposed method, MRB was successfully assayed in pharmaceutical formulations and surface water samples with mean average recoveries agreeable with the official method.

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Improved liquid chromatographic determination of nine currently used (fluoro)quinolones with fluorescence and mass spectrometric detection for environmental samples

Ferdig¹,

Kaleta

Buchberger

2005

J of Separation Science

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An HPLC method using C18-modified silica as stationary phase has been developed for environmental trace analysis of nine (fluoro)quinolones. Detection is done by fluorescence measurement or MS using the modes of SIM and selected reaction monitoring (SRM). Best separation is achieved with a gradient consisting of 50 mM formic acid and methanol, which is fully compatible with MS coupling. LOQs (S/N of 10) for fluorescence detection are between 10 and 60 microg/L, depending on the analyte. MS detection (SIM and SRM) yields LOQs that are better by a factor of at least an order of magnitude. Sample preconcentration and sample clean-up is accomplished by SPE (preconcentration factor of 1000), leading to LOQs in the low ng/L range. Recoveries of the preconcentration procedure are better than 80% for all analytes. The suitability for real samples has been demonstrated by analyzing surface waters, municipal waste waters, sewage treatment plant effluents, sewage sludge, and sediment taken from rivers and fish ponds. The method should also be useful for determination of residues of (fluoro)quinolones in food or other matrices. The degradation of the (fluoro)quinolones has been examined over 5 days in order to get information about the decomposition rate and the degradation products eventually occurring in the environment.

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Determination of quinolones in water samples by solid-phase extraction and liquid chromatography with fluorimetric detection

Cited by 68 publications

References 20 publications

An overview of analytical methodologies for the determination of antibiotics in environmental waters

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Voltammetric Determination of Marbofloxacin at Carbon Paste Sensor Integrated with Copper Oxide Nanoparticles

Improved liquid chromatographic determination of nine currently used (fluoro)quinolones with fluorescence and mass spectrometric detection for environmental samples

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